COO Jobs in North Carolina
COO jobs in North Carolina draw consistent demand across financial services, life sciences, technology, and logistics, with openings at every level from emerging executive to seasoned operational leader. Charlotte, Raleigh, and the Research Triangle are the primary hiring hubs, anchored by major employers such as Bank of America, Duke University Health System, and Red Hat. The most sought-after specialties in North Carolina include operational transformation, supply chain leadership, and scaling growth-stage companies in the Research Triangle's biotech and SaaS sectors. Find a role that fits below and apply directly.
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Job Summary
The Senior Director, Warehouse Operations is responsible for strategic leadership, operational performance, and continuous improvement of all warehouses, inventory, logistics, warehouse purchases, warehouse systems, GMP shipping, and storeroom activities across KBI's North Carolina network. This role provides leadership through direct oversight of warehouse operations leaders and staff, ensuring the safe, compliant, efficient, and uninterrupted flow of materials supporting manufacturing operations and customer commitments.
The Senior Director owns the strategy, governance, performance, and scalability of warehouse operations, inventory management, transportation, distribution, cold chain activities, warehouse automation, ERP/WMS platforms, and supply chain operational excellence initiatives. This position is responsible for establishing policies, standards, and business processes that drive compliance, inventory accuracy, service excellence, cost optimization, and operational readiness while supporting future growth and enterprise transformation initiatives.
This role is critical to enabling KBI's growth strategy and CDMO success, providing enterprise leadership for warehouse operations, inventory stewardship, and supply chain execution while driving a culture of safety, accountability, continuous improvement, and employee engagement across the organization.
Job Responsibilities
- Provide strategic leadership and oversight for all warehouse, inventory, material flow, logistics, distribution, storage, and material management operations, ensuring uninterrupted support of manufacturing, customer commitments, and business growth.
- Lead and develop the Warehouse Operations organization, including multi-site leadership teams, fostering a culture of safety, accountability, operational excellence, employee engagement, and continuous improvement.
- Own operational performance across the warehouse network, including safety, compliance, inventory accuracy, quality, service levels, productivity, cost management, and key performance indicators.
- Establish and maintain governance for warehouse operations and inventory management, including policies, procedures, financial controls, material traceability, audit readiness, and regulatory compliance.
- Lead capacity planning, network optimization, labor strategy, operational readiness, and business continuity initiatives to support current and future business requirements.
- Serve as executive sponsor for warehouse technology and digital transformation initiatives, including SAP, WMS/EWM, automation, system enhancements, data integrity, analytics, and process standardization.
- Oversee transportation, logistics, and distribution strategy, including carrier management, third-party logistics providers, freight optimization, cold-chain operations, and service performance.
- Drive operational excellence and enterprise initiatives focused on productivity improvement, risk reduction, scalability, supply assurance, and cost optimization.
- Partner with Manufacturing, Procurement, Planning, Quality, Finance, Facilities, Engineering, IT, and Program Management to align supply chain capabilities with business objectives and customer needs.
- Serve as the senior warehouse and supply chain representative for executive leadership, audits, regulatory inspections, customer interactions, strategic planning, budget development, capital investments, and other business initiatives as required.
Responsibilities
- Warehouse Operations, Inventory, Logistics & Distribution Oversight
- Leadership, Talent Development & Organizational Effectiveness
- Strategy, Capacity Planning & Business Continuity
- Systems, Digital Transformation & Operational Excellence
- Compliance, Governance & Financial Stewardship
- Executive leadership & Cross-functional engagement
Minimum Requirements
- Bachelor's degree in Supply Chain, Business, Operations, Engineering, Logistics, Life Sciences, or a related field. Advanced degree (MBA, MS, or equivalent) preferred. Equivalent experience may be considered in lieu of education.
- 12+ years of progressive supply chain, warehouse operations, logistics, or materials management experience within a pharmaceutical, biotechnology, life sciences, or other regulated manufacturing environment.
- 5+ years of leadership experience managing managers and/or directors, including responsibility for multi-site operations and organizational development.
- Demonstrated experience leading warehouse operations, inventory management, material flow, transportation, distribution, and logistics functions in GMP-regulated environments.
- Proven experience developing and executing operational strategies that improve safety, compliance, service, inventory accuracy, productivity, scalability, and cost performance.
- Strong knowledge of GMP, GDP, inventory control, material traceability, warehouse compliance requirements, and regulatory inspection readiness.
- Significant experience with ERP and warehouse technology platforms, including SAP, WMS/EWM, inventory management systems, automation technologies, and digital transformation initiatives.
- Demonstrated success leading large-scale business, operational, system implementation, or organizational transformation projects.
- Experience establishing and managing KPIs, budgets, capital investments, resource planning, and operational performance metrics.
- Strong financial acumen with experience managing departmental budgets, operational expenditures, capital planning, and cost optimization initiatives.
- Proven ability to influence senior leadership and drive alignment across Manufacturing, Procurement, Planning, Quality, Finance, Engineering, Facilities, IT, and other cross-functional stakeholders.
- Strong analytical problem-solving, decision-making, and risk-management capabilities.
- Excellent verbal, written, presentation, and interpersonal communication skills.
- Willingness to travel up to 25% based on business needs.
Language Ability
- Ability to read, analyze, and interpret general business periodicals, professional journals, technical procedures, or governmental regulations. Ability to write reports, business correspondence, and procedure manuals. Ability to effectively present information and respond to questions from groups of managers, clients, and customers.
Reasoning Ability
- Ability to solve practical problems and deal with a variety of concrete variables in situations where only limited standardization exists. Ability to interpret a variety of instructions furnished in written, oral, diagram, or schedule form
Math Ability
- Ability to perform business related calculations such as discounts, interest, commissions, proportions, percentages and area, circumference and volume. Ability to apply concepts of basic algebra and geometry.
Competencies
- Talent Management/Hiring/Performance Management
- Business Acumen
- Priority Setting
- Problem Solving/Decision Quality
- Results Orientation/Performance Focus
- Project Management/Managing and Measuring Work
- Communication Proficiency.
- Integrity and Personal Responsibility
- Action Oriented (Results Orientation/
- Performance Focus)
- Functional/Technical Skills
- Customer Focus
- Delegation
- Interpersonal Savvy/ Respect for Others
- Technical Capacity
- Presentation Skills
Computer Skills
- Word, E-mail, Excel, PowerPoint, MS Project (preferred), ERP Systems (SAP, or similar).
Equipment Use
- Computer, telephone, copy and fax machines
KBI Biopharma, Inc. is an EEO/AA employer and actively seeks to diversify its work force. Therefore, all qualified applicants, regardless of race, color, national origin, religion, gender, gender identity, sexual orientation, age, disability or veteran status, are strongly encouraged to apply.
I understand that neither the completion of this application nor any other part of my consideration for employment establishes any obligation for KBI Biopharma, Inc. to hire me. If I am hired, I understand that either KBI Biopharma, Inc. or I can terminate my employment at any time and for any reason, with or without cause and without prior notice. I understand that no representative of KBI Biopharma, Inc. has the authority to make any assurance to the contrary.
I attest with my signature below that I have given to KBI Biopharma, Inc. true and complete information on this application. No requested information has been concealed. I authorize KBI Biopharma, Inc. to contact references provided for employment reference checks. If any information I have provided is untrue, or if I have concealed material information, I understand that this will constitute cause for the denial of employment or immediate dismissal.
See All 108+ COO Jobs in North Carolina
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Find COO JobsCOO Jobs by City in North Carolina
Where North Carolina roles are concentrated, by current openings.
COO Job Market in North Carolina
A snapshot from current North Carolina openings, updated as new roles post.
Who's Hiring



Top Industries Hiring
- Consulting & Professional Services
- Technology & Software
- Biotechnology & Pharmaceuticals
- Energy
- Manufacturing
What North Carolina Employers Look For
The qualifications that appear most often in COO jobs across North Carolina.
- Bachelor's degree required, with a master's degree strongly preferred by most North Carolina employers
- Ten or more years of progressive leadership experience in operations or a related function
- Demonstrated ability to lead cross-functional teams and manage P&L responsibility
- Experience in one of North Carolina's core industries: financial services, life sciences, or technology
- Strong background in operational process improvement, including Lean or Six Sigma methodologies
- Proven ability to partner with a CEO or board to execute and refine organizational strategy
COO Jobs in North Carolina: Frequently Asked Questions
How do you become a coo in North Carolina?
Becoming a coo in North Carolina typically requires a bachelor's degree in business, operations, or a related field, with most employers preferring an MBA or equivalent graduate credential. There is no state-issued license specific to the coo role in North Carolina, so the path runs through progressively senior operational roles. Many North Carolina executives build their base at large employers in Charlotte's financial sector, the Research Triangle's tech and biotech companies, or the state's major health systems before stepping into a coo seat.
Which companies hire coos in North Carolina?
Employers hiring coos in North Carolina right now include Cornerstone Caregiving, Lenovo, and TerraBella Senior Living, based on current listings on Migrate Mate as of August 2026. North Carolina's blend of Fortune 500 headquarters in Charlotte, research-driven organizations in the Triangle, and a growing logistics corridor along the I-85 and I-40 corridors means openings are distributed across both large established names and high-growth mid-market companies.
Which North Carolina cities have the most coo jobs?
The cities with the most coo openings in North Carolina are Charlotte, Raleigh, and Durham. Charlotte leads because it is home to major banking, insurance, and energy headquarters, while Raleigh and Durham benefit from the density of technology, biotech, and university-affiliated organizations in the Research Triangle, which consistently generates senior operational leadership demand across both established companies and venture-backed firms.
Are there remote coo jobs in North Carolina?
Yes, but they are rare. The coo role is inherently hands-on, requiring regular presence with leadership teams, facilities, and staff, which limits fully remote arrangements. About 35% of coo openings tied to North Carolina are remote or hybrid as of August 2026, and when flexibility exists it tends to appear in technology companies or professional services firms where operations can be coordinated without a fixed on-site requirement.
How can I get hired as a coo in North Carolina with little or no experience?
The most realistic entry path is through a director-level operations or general management role at a North Carolina employer, using that position to build the cross-functional visibility coo candidates need. Large health systems such as Atrium Health and UNC Health run structured operations management development programs, and Research Triangle biotech companies regularly promote from within their operations and program management teams. Earning an MBA from a North Carolina institution such as UNC Kenan-Flagler or Duke Fuqua also opens direct access to companies actively recruiting operational leadership talent.
Where can I find and apply to coo jobs in North Carolina?
You can find and apply to coo jobs in North Carolina on Migrate Mate, which lists current openings from employers across the state. Search the listings, find the roles that match your background and target location, and apply directly to each one.
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