COO Jobs in Massachusetts

COO jobs in Massachusetts are in strong demand, with openings concentrated in life sciences, financial services, technology, and healthcare across a market that ranges from early-career operations managers stepping into executive tracks to seasoned C-suite leaders. Boston, Cambridge, and Worcester anchor most of the hiring, where organizations like Mass General Brigham, State Street, and Fidelity Investments maintain large, established operations and regularly seek senior operational leadership. The most in-demand specialties include healthcare operations, biotech and pharmaceutical operations, and fintech and asset management operations. Find a role that fits below and apply directly.

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Overview

Open roles176+
Top employerVertex Pharmaceuticals
Top cityBoston, MA
Cities hiring53
Work type48% On-site
Top industryBiotechnology

Showing 5 of 176+ COO jobs

Heywood Hospital
Director of Facilities, Plant Operations, 40-Hours, Days
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Heywood Hospital
Added 1d ago
Director of Facilities, Plant Operations, 40-Hours, Days
Heywood Hospital
Gardner, Massachusetts
Business Operations
Compensation & Benefits
Human Resources (HR) — Generalist
$125k - $175k/yr
Bachelor's degree
1,001-5,000

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Collegium Pharmaceutical, Inc.
Director, Clinical Operations
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Collegium Pharmaceutical, Inc.
Added 1d ago
Director, Clinical Operations
Collegium Pharmaceutical, Inc.
Stoughton, Massachusetts
Business Operations
Program Management
Project Management
$215k - $253k/yr
Bachelor of Science
201-500

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IPG Photonics Corporation
Sr. Director, Operations
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IPG Photonics Corporation
Added 1d ago
Sr. Director, Operations
IPG Photonics Corporation
Marlborough, Massachusetts
Business Development
Executive Leadership & C-Suite
Partnerships & Business Development
Master's degree in business administration
1,001-5,000

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Biogen
Associate Director, Medical Strategy & Operations Lead - Rare Disease (US Medical Affairs)
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Biogen
Added 1d ago
Associate Director, Medical Strategy & Operations Lead - Rare Disease (US Medical Affairs)
Biogen
Cambridge, Massachusetts
Brand & Social Media
Content & Communications
Marketing
$162k - $223k/yr
Hybrid
Master's degree in business administration
5,001-10,000

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Thermo Fisher Scientific
Sr Director, Commercial Operations
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Thermo Fisher Scientific
Added 1d ago
Sr Director, Commercial Operations
Thermo Fisher Scientific
Massachusetts
Communications
Content & Communications
Public Relations (PR)
$193k - $275k/yr
Bachelor's degree in business
10,000+

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See All 176+ COO Jobs in Massachusetts

Find roles in Massachusetts that match your experience and apply in just a few clicks.

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COO Jobs by City in Massachusetts

Where Massachusetts roles are concentrated, by current openings.

Waltham
10 jobs
Somerville
6 jobs
Lexington
5 jobs
Worcester
5 jobs
Lowell
3 jobs
Needham
3 jobs
Watertown
3 jobs

COO Job Market in Massachusetts

A snapshot from current Massachusetts openings, updated as new roles post.

Who's Hiring

  • Vertex Pharmaceuticals
    Vertex Pharmaceuticals10
  • Flagship Pioneering
    Flagship Pioneering8
  • Takeda Pharmaceuticals
    Takeda Pharmaceuticals6
  • Harvard University
    Harvard University4

Top Industries Hiring

  • Biotechnology & Pharmaceuticals12
  • Science & Research10
  • Education5
  • Medical Devices3
  • Healthcare & Medical Services3

What Massachusetts Employers Look For

The qualifications that appear most often in COO jobs across Massachusetts.

  • Bachelor's degree in business administration, operations management, or a related field required
  • Ten or more years of progressive leadership experience in operations or general management
  • Demonstrated experience leading cross-functional teams and managing P&L responsibility
  • Deep knowledge of Massachusetts industry sector the employer operates in, such as life sciences or financial services
  • Experience scaling operations within a regulated environment, including compliance and risk oversight
  • Strong strategic planning and data-driven decision-making skills backed by measurable outcomes

COO Jobs in Massachusetts: Frequently Asked Questions

How do you become a coo in Massachusetts?

There is no state-issued license required to work as a coo in Massachusetts, so the path runs through education and career progression. Most hiring organizations expect a bachelor's degree in business, operations, or a related field, with an MBA strongly preferred for senior roles. The typical route involves building leadership experience across functional areas such as finance, supply chain, or product, often within Massachusetts's dominant sectors of life sciences, healthcare, or financial services, before moving into a chief operating role.

Which companies hire coos in Massachusetts?

Employers hiring coos in Massachusetts right now include Vertex Pharmaceuticals, Takeda Pharmaceuticals, and Harvard University, based on current listings on Migrate Mate as of August 2026. Massachusetts's concentration of biotech firms, academic medical centers, and asset managers means demand for operational leadership stays consistent across both established enterprises and growth-stage companies.

Which Massachusetts cities have the most coo jobs?

Boston, Cambridge, and Waltham have the most coo openings in Massachusetts. Boston drives the majority of listings given its density of hospital systems, financial institutions, and technology headquarters, while Cambridge's biotech corridor and Worcester's growing healthcare and manufacturing base pull in additional demand beyond the core metro.

Are there remote coo jobs in Massachusetts?

Yes, but they're less common than in purely analytical roles because coos typically oversee people, facilities, and day-to-day operations that require an on-site or hybrid presence. About 52% of coo openings tied to Massachusetts are remote or hybrid as of August 2026, reflecting that hybrid arrangements are more accepted than fully remote. Strategy, reporting, and cross-functional coordination duties are the portions of the role most often performed off-site.

How can I get hired as a coo in Massachusetts with little or no experience?

The most realistic entry path is building operational leadership experience in a director or VP of operations role within a Massachusetts employer before moving into a coo position. Large Massachusetts health systems such as Mass General Brigham and Beth Israel Deaconess Medical Center run structured leadership development programs that place emerging leaders across operational departments. Titles like director of operations, general manager, or VP of strategy are the most common stepping-stone roles, and an MBA from a Massachusetts institution adds a measurable edge for candidates making that transition.

Where can I find and apply to coo jobs in Massachusetts?

You can find and apply to coo jobs in Massachusetts on Migrate Mate, which lists current openings across the state. Search the available roles, find the ones that fit your background and target sector, and apply directly to the employers posting them.

See All 176+ COO Jobs in Massachusetts

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