COO Jobs in Massachusetts

COO jobs in Massachusetts are in strong demand, with openings concentrated in life sciences, financial services, technology, and healthcare across a market that ranges from early-career operations managers stepping into executive tracks to seasoned C-suite leaders. Boston, Cambridge, and Worcester anchor most of the hiring, where organizations like Mass General Brigham, State Street, and Fidelity Investments maintain large, established operations and regularly seek senior operational leadership. The most in-demand specialties include healthcare operations, biotech and pharmaceutical operations, and fintech and asset management operations. Find a role that fits below and apply directly.

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Overview

Open roles181+
Top employerTakeda Pharmaceuticals
Top cityBoston, MA
Cities hiring56
Work type59% Hybrid
Top industryBiotechnology

Showing 5 of 181+ COO jobs

GE Aerospace
Senior Director – Program & Operations Leader, ITC
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GE Aerospace
Added 2d ago
Senior Director – Program & Operations Leader, ITC
GE Aerospace
Lynn, Massachusetts
Clinical Support
Healthcare Administration
Medical Specialists
$181k - $241k/yr
High school diploma or GED
10,000+

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Vecna Robotics
Director of IT Operations and Security
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Vecna Robotics
Added 2d ago
Director of IT Operations and Security
Vecna Robotics
Waltham, Massachusetts
Creative & Design
Product Management
UI/UX Design
$156k - $224k/yr
Master's degree
51-200

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Viridian Therapeutics
Director, Clinical Operations
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Viridian Therapeutics
Added 2d ago
Director, Clinical Operations
Viridian Therapeutics
Waltham, Massachusetts
Business Operations
Executive Leadership & C-Suite
Project & Program Management
Project Management
$200k - $245k/yr
Hybrid
Bachelor of Science

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City of Boston
Deputy Director of Operations
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City of Boston
Added 3d ago
Deputy Director of Operations
City of Boston
Boston, Massachusetts
Business Development
Executive Leadership & C-Suite
Partnerships & Business Development
$91k.15 - $129k.83/yr
Master's degree in public administration
1,001-5,000

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Massachusetts Eye and Ear
Director of Operations
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Massachusetts Eye and Ear
Added 3d ago
Director of Operations
Massachusetts Eye and Ear
Boston, Massachusetts
Business Analysis
Data Analytics
IT Support
Systems Administration
$124k.4 - $181k.59/yr
Bachelor's degree in business
1,001-5,000

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COO Jobs by City in Massachusetts

Where Massachusetts roles are concentrated, by current openings.

Waltham
8 jobs
Somerville
4 jobs
Charlestown
4 jobs
Andover
3 jobs
Watertown
3 jobs
Wellesley
3 jobs
Worcester
3 jobs

COO Job Market in Massachusetts

A snapshot from current Massachusetts openings, updated as new roles post.

Who's Hiring

Takeda Pharmaceuticals
Takeda Pharmaceuticals7 open roles
Beth Israel Lahey Health
Beth Israel Lahey Health5 open roles
Vertex Pharmaceuticals
Vertex Pharmaceuticals4 open roles

Top Industries Hiring

  • Biotechnology & Pharmaceuticals
  • Education
  • Science & Research
  • Staffing & Recruiting
  • Construction & Real Estate

What Massachusetts Employers Look For

The qualifications that appear most often in COO jobs across Massachusetts.

  • Bachelor's degree in business administration, operations management, or a related field required
  • Ten or more years of progressive leadership experience in operations or general management
  • Demonstrated experience leading cross-functional teams and managing P&L responsibility
  • Deep knowledge of Massachusetts industry sector the employer operates in, such as life sciences or financial services
  • Experience scaling operations within a regulated environment, including compliance and risk oversight
  • Strong strategic planning and data-driven decision-making skills backed by measurable outcomes

COO Jobs in Massachusetts: Frequently Asked Questions

How do you become a coo in Massachusetts?

There is no state-issued license required to work as a coo in Massachusetts, so the path runs through education and career progression. Most hiring organizations expect a bachelor's degree in business, operations, or a related field, with an MBA strongly preferred for senior roles. The typical route involves building leadership experience across functional areas such as finance, supply chain, or product, often within Massachusetts's dominant sectors of life sciences, healthcare, or financial services, before moving into a chief operating role.

Which companies hire coos in Massachusetts?

Employers hiring coos in Massachusetts right now include Takeda Pharmaceuticals, Beth Israel Lahey Health, and Vertex Pharmaceuticals, based on current listings on Migrate Mate as of September 2026. Massachusetts's concentration of biotech firms, academic medical centers, and asset managers means demand for operational leadership stays consistent across both established enterprises and growth-stage companies.

Which Massachusetts cities have the most coo jobs?

Boston, Cambridge, and Waltham have the most coo openings in Massachusetts. Boston drives the majority of listings given its density of hospital systems, financial institutions, and technology headquarters, while Cambridge's biotech corridor and Worcester's growing healthcare and manufacturing base pull in additional demand beyond the core metro.

Are there remote coo jobs in Massachusetts?

Yes, but they're less common than in purely analytical roles because coos typically oversee people, facilities, and day-to-day operations that require an on-site or hybrid presence. About 76% of coo openings tied to Massachusetts are remote or hybrid as of September 2026, reflecting that hybrid arrangements are more accepted than fully remote. Strategy, reporting, and cross-functional coordination duties are the portions of the role most often performed off-site.

How can I get hired as a coo in Massachusetts with little or no experience?

The most realistic entry path is building operational leadership experience in a director or VP of operations role within a Massachusetts employer before moving into a coo position. Large Massachusetts health systems such as Mass General Brigham and Beth Israel Deaconess Medical Center run structured leadership development programs that place emerging leaders across operational departments. Titles like director of operations, general manager, or VP of strategy are the most common stepping-stone roles, and an MBA from a Massachusetts institution adds a measurable edge for candidates making that transition.

Where can I find and apply to coo jobs in Massachusetts?

You can find and apply to coo jobs in Massachusetts on Migrate Mate, which lists current openings across the state. Search the available roles, find the ones that fit your background and target sector, and apply directly to the employers posting them.

See All 181+ COO Jobs in Massachusetts

Find roles in Massachusetts that match your experience and apply in just a few clicks.

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