NP Jobs in Missouri

NP jobs in Missouri are concentrated in St. Louis, Kansas City, and Springfield, where major health systems including BJC HealthCare, Saint Luke's Health System, and Mercy Health drive consistent hiring across primary care, acute care, and psychiatric specialties. Demand is strong at every experience level, from new graduates completing their first clinical role to seasoned NPs moving into leadership or specialty practice. Missouri's full-practice authority status makes the state attractive to NPs seeking autonomy, which keeps the pipeline competitive but active. Scan the live roles below and apply to whichever ones fit.

Find NP Jobs in Missouri

Overview

Open roles77
Top employerMercy
Top citySt. Louis, MO
Cities hiring32
Work type70% On-site
Top industryHealthcare

Showing 5 of 77+ NP jobs

US Department of Veterans Affairs
Psychiatric Advanced Practice Registered Nurse - Mental Health
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US Department of Veterans Affairs
Added 1d ago
Psychiatric Advanced Practice Registered Nurse - Mental Health
US Department of Veterans Affairs
Poplar Bluff, Missouri
Customer Service
Customer Support
Hospitality & Guest Services
$115k - $168k/yr
On-Site
Post-Master's Certificate (Nursing)
10,000+

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Centurion Health
PRN Nurse Practitioner (NP/PA) - Vandalia, Missouri
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Centurion Health
Added 1d ago
PRN Nurse Practitioner (NP/PA) - Vandalia, Missouri
Centurion Health
Vandalia, Missouri
Business Development
Growth Marketing
Marketing
5,001-10,000

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Mercy
Nurse Practitioner or Physician Assistant - OBGYN Smith Glynn Callaway Clinic - Springfield, MO
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Mercy
Added 1d ago
Nurse Practitioner or Physician Assistant - OBGYN Smith Glynn Callaway Clinic - Springfield, MO
Mercy
Springfield, Missouri
Clinical Support
Healthcare Administration
Medical Specialists
10,000+

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CVS Health
Nurse Practitioner
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CVS Health
Added 1d ago
Nurse Practitioner
CVS Health
Ballwin, Missouri
Nursing
Healthcare Administration
Patient Services & Wellbeing
$41 - $90/hr
On-Site
Master's
10,000+

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CVS Health
Nurse Practitioner
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CVS Health
Added 1d ago
Nurse Practitioner
CVS Health
Ellisville, Missouri
Nursing
Healthcare Administration
Patient Services & Wellbeing
$41 - $90/hr
On-Site
Master's
10,000+

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See All 77 NP Jobs in Missouri

Find roles in Missouri that match your experience and apply in just a few clicks.

Find NP Jobs in Missouri

NP Jobs by City in Missouri

Where Missouri roles are concentrated, by current openings.

Springfield
11 jobs
Columbia
4 jobs
O'Fallon
3 jobs
Chesterfield
3 jobs
Joplin
2 jobs
Lebanon
2 jobs
Saint Peters
2 jobs

NP Job Market in Missouri

A snapshot from current Missouri openings, updated as new roles post.

Who's Hiring

  • Mercy
    Mercy10
  • TeamHealth
    TeamHealth6
  • CoxHealth
    CoxHealth5
  • CVS Health
    CVS Health4
  • BJC HealthCare
    BJC HealthCare3

Top Industries Hiring

  • Healthcare & Medical Services
  • Insurance

What Missouri Employers Look For

The qualifications that appear most often in NP jobs across Missouri.

  • Active Missouri NP license issued by the Missouri State Board of Nursing
  • Current national board certification from AANP or ANCC in a recognized specialty
  • Master of Science in Nursing or Doctor of Nursing Practice from an accredited program
  • Active, unrestricted registered nurse license in Missouri or a compact state
  • Current DEA registration and Missouri controlled substance license for prescribing roles
  • Basic Life Support certification with ACLS required for acute care and hospital positions

NP Jobs in Missouri: Frequently Asked Questions

How do you become a np in Missouri?

To become an NP in Missouri, you must first hold an active registered nurse license, then complete a graduate-level NP program and pass a national certification exam through AANP or ANCC. You apply for your advanced practice registered nurse license through the Missouri State Board of Nursing, which also requires a Missouri controlled substance license if you plan to prescribe. Missouri grants full-practice authority to licensed NPs, so no physician collaboration agreement is required to practice independently.

Which companies hire nps in Missouri?

Missouri np roles are posted by Mercy, TeamHealth, and CoxHealth and others right now, based on current listings on Migrate Mate as of August 2026. Missouri's largest hiring volume comes from its major integrated health systems, federally qualified health centers, and the Veterans Affairs facilities serving the state.

Which Missouri cities have the most np jobs?

St. Louis, Kansas City, and Springfield have the most np openings in Missouri right now. St. Louis and Kansas City dominate because of their large academic medical centers, multi-hospital health systems, and dense outpatient clinic networks, while Springfield serves as the regional hub for southwest Missouri, anchored by CoxHealth and Mercy.

Are there remote np jobs in Missouri?

Yes, but they're rare. About 30% of np openings tied to Missouri are remote or hybrid as of August 2026, reflecting that most NP work requires direct patient contact. The roles most likely to offer remote or hybrid arrangements are those focused on telehealth primary care, chronic disease management, and psychiatric or behavioral health consultations.

How can I get hired as a np in Missouri with little or no experience?

The most realistic entry path is a new-graduate NP residency or fellowship program, and Missouri has several worth targeting: BJC HealthCare and Mercy Health both run structured onboarding programs for new advanced practice providers in primary care and hospital medicine. Coming in as an NP in a federally qualified health center is another strong option, as these organizations frequently hire new graduates and offer loan repayment incentives. NPs with a background as an RN in critical care or emergency nursing have a measurable edge, and holding both your ANCC or AANP certification and your Missouri controlled substance license before applying removes a common hiring delay.

Where can I find and apply to np jobs in Missouri?

You can find and apply to np jobs in Missouri on Migrate Mate, which lists current Missouri openings updated in real time. Search the roles that match your specialty and experience level, then apply directly to the ones that fit.

See All 77 NP Jobs in Missouri

Find roles in Missouri that match your experience and apply in just a few clicks.

Find NP Jobs in Missouri