NP Jobs in Missouri
NP jobs in Missouri are concentrated in St. Louis, Kansas City, and Springfield, where major health systems including BJC HealthCare, Saint Luke's Health System, and Mercy Health drive consistent hiring across primary care, acute care, and psychiatric specialties. Demand is strong at every experience level, from new graduates completing their first clinical role to seasoned NPs moving into leadership or specialty practice. Missouri's full-practice authority status makes the state attractive to NPs seeking autonomy, which keeps the pipeline competitive but active. Scan the live roles below and apply to whichever ones fit.
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- Monday and Wednesday: 9:00 AM–7:00 PM
- Tuesday, Thursday, and Friday: 9:00 AM–5:00 PM
- Collaborative, multidisciplinary approach to patient care
- Dedicated Medical Assistant support, including assistance with documentation
- Ultrasound or fluoroscopic guidance for procedures
- Access to PRP treatments, Botox migraine protocols, and advanced pain-management techniques
- Training in procedures and diagnostic imaging interpretation
- Emphasis on patient education, continuity of care, and functional improvement
- Evaluate patients with pain-related and musculoskeletal conditions
- Develop individualized treatment plans in collaboration with the care team
- Perform, or train to perform, procedures within your scope of practice, including:
- Trigger point and tendon injections
- Joint and sacroiliac injections
- Peripheral nerve blocks
- PRP injections
- Botox migraine treatments
- Order and coordinate Physical Therapy, Occupational Therapy, and Chiropractic services
- Review and interpret diagnostic imaging, with training provided
- Educate patients on treatment options, care plans, and recovery goals
- Monitor treatment response and coordinate appropriate follow-up care
- Maintain accurate and timely clinical documentation
- Active Nurse Practitioner licensure in both Missouri and Kansas required
- Ability and willingness to obtain DOT certification within 90 days of hire
- Strong foundational knowledge of orthopedic and musculoskeletal conditions
- Willingness to learn injection techniques and pain-management procedures
- Strong communication skills and the ability to build patient trust
- Collaborative, patient-focused approach to care
- Commitment to continued learning and professional development
- Full-time compensation: $85,000–$110,000 annually
- Part-time compensation: $40–$45 per hour
- Health insurance
- Supplemental health insurance
- SIMPLE IRA with a 3% employer match
- Whole life insurance policy
- Two weeks of paid time off
- Continuing education allowance
- No weekends or call responsibilities
See All 94 NP Jobs in Missouri
Find roles in Missouri that match your experience and apply in just a few clicks.
Find NP Jobs in MissouriNP Jobs by City in Missouri
Where Missouri roles are concentrated, by current openings.
NP Job Market in Missouri
A snapshot from current Missouri openings, updated as new roles post.
Who's Hiring
Top Industries Hiring
- Education
- Technology & Software
- Healthcare & Medical Services
What Missouri Employers Look For
The qualifications that appear most often in NP jobs across Missouri.
- Active Missouri NP license issued by the Missouri State Board of Nursing
- Current national board certification from AANP or ANCC in a recognized specialty
- Master of Science in Nursing or Doctor of Nursing Practice from an accredited program
- Active, unrestricted registered nurse license in Missouri or a compact state
- Current DEA registration and Missouri controlled substance license for prescribing roles
- Basic Life Support certification with ACLS required for acute care and hospital positions
NP Jobs in Missouri: Frequently Asked Questions
How do you become a np in Missouri?
To become an NP in Missouri, you must first hold an active registered nurse license, then complete a graduate-level NP program and pass a national certification exam through AANP or ANCC. You apply for your advanced practice registered nurse license through the Missouri State Board of Nursing, which also requires a Missouri controlled substance license if you plan to prescribe. Missouri grants full-practice authority to licensed NPs, so no physician collaboration agreement is required to practice independently.
Which companies hire nps in Missouri?
Missouri np roles are posted by Mercy, SSM Health, and BJC HealthCare and others right now, based on current listings on Migrate Mate as of October 2026. Missouri's largest hiring volume comes from its major integrated health systems, federally qualified health centers, and the Veterans Affairs facilities serving the state.
Which Missouri cities have the most np jobs?
St. Louis, Kansas City, and Springfield have the most np openings in Missouri right now. St. Louis and Kansas City dominate because of their large academic medical centers, multi-hospital health systems, and dense outpatient clinic networks, while Springfield serves as the regional hub for southwest Missouri, anchored by CoxHealth and Mercy.
Are there remote np jobs in Missouri?
Yes, but they're rare. About 33% of np openings tied to Missouri are remote or hybrid as of October 2026, reflecting that most NP work requires direct patient contact. The roles most likely to offer remote or hybrid arrangements are those focused on telehealth primary care, chronic disease management, and psychiatric or behavioral health consultations.
How can I get hired as a np in Missouri with little or no experience?
The most realistic entry path is a new-graduate NP residency or fellowship program, and Missouri has several worth targeting: BJC HealthCare and Mercy Health both run structured onboarding programs for new advanced practice providers in primary care and hospital medicine. Coming in as an NP in a federally qualified health center is another strong option, as these organizations frequently hire new graduates and offer loan repayment incentives. NPs with a background as an RN in critical care or emergency nursing have a measurable edge, and holding both your ANCC or AANP certification and your Missouri controlled substance license before applying removes a common hiring delay.
Where can I find and apply to np jobs in Missouri?
You can find and apply to np jobs in Missouri on Migrate Mate, which lists current Missouri openings updated in real time. Search the roles that match your specialty and experience level, then apply directly to the ones that fit.
See All 94 NP Jobs in Missouri
Find roles in Missouri that match your experience and apply in just a few clicks.
Find NP Jobs in Missouri