NP Jobs in South Dakota

NP jobs in South Dakota are open across Sioux Falls, Rapid City, and Huron and other South Dakota metros, with employers like Sanford Health, Huron Regional Medical Center, and Sioux Center Health hiring at every experience level. Find a role that fits below and apply directly.

Find NP Jobs

Overview

Open roles34+
Top employerSanford Health
Top citySioux Falls, SD
Cities hiring9
Work type97% On-site
Top industryHealthcare

Showing 5 of 34+ NP jobs

Sanford Health
Nurse Practitioner or Physician Assistant
We won't show you this job again
Sanford Health
Added 3d ago
Nurse Practitioner or Physician Assistant
Sanford Health
Rapid City, South Dakota
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
Master's
10,000+

Have you applied for this role?

Sanford Health
Nurse Practitioner or Physician Assistant
We won't show you this job again
Sanford Health
Added 5d ago
Nurse Practitioner or Physician Assistant
Sanford Health
Aberdeen, South Dakota
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
Other
10,000+

Have you applied for this role?

Sanford Health
Nurse Practitioner or Physician Assistant
We won't show you this job again
Sanford Health
Added 6d ago
Nurse Practitioner or Physician Assistant
Sanford Health
Watertown, South Dakota
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
Master's
10,000+

Have you applied for this role?

Sanford Health
Nurse Practitioner or Physician Assistant
We won't show you this job again
Sanford Health
Added 1w ago
Nurse Practitioner or Physician Assistant
Sanford Health
Sioux Falls, South Dakota
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
Master's
10,000+

Have you applied for this role?

Huron Regional Medical Center
Physician Assistant or Nurse Practitioner
We won't show you this job again
Huron Regional Medical Center
Added 1w ago
Physician Assistant or Nurse Practitioner
Huron Regional Medical Center
Huron, South Dakota
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
None
201-500

Have you applied for this role?

See All 34 NP Jobs in South Dakota

Find roles in South Dakota that match your experience and apply in just a few clicks.

Find NP Jobs

NP Jobs by City in South Dakota

Where South Dakota roles are concentrated, by current openings.

Sioux Falls
9 jobs
Rapid City
7 jobs
Huron
6 jobs
Aberdeen
4 jobs
Pierre
3 jobs
Sd
2 jobs
Brookings
1 jobs
Watertown
1 jobs
Webster
1 jobs

NP Job Market in South Dakota

A snapshot from current South Dakota openings, updated as new roles post.

Who's Hiring

  • Sanford Health
    Sanford Health17
  • Huron Regional Medical Center
    Huron Regional Medical Center6
  • Sioux Center Health
    Sioux Center Health5
  • Monument Health
    Monument Health2
  • Sanford Bismarck
    Sanford Bismarck2

Top Industries Hiring

  • Healthcare & Medical Services34
  • Non-Profit & Social Services1

What South Dakota Employers Look For

The qualifications that appear most often in NP jobs across South Dakota.

  • Master of Science in Nursing or Doctor of Nursing Practice from an accredited program
  • Active national board certification from AANP or ANCC in relevant specialty
  • Current, unrestricted registered nurse and nurse practitioner licensure in the state of practice
  • Two or more years of clinical experience in a related care setting
  • Proficiency with electronic health records systems such as Epic, Cerner, or Athena
  • Current DEA registration or eligibility to obtain one upon hire

NP Jobs in South Dakota: Frequently Asked Questions

How many NP jobs are there in South Dakota?

There are 34+ NP openings in South Dakota on Migrate Mate as of June 2026, with the most roles in Sioux Falls, Rapid City, and Huron. New positions post regularly as employers across South Dakota hire.

Which South Dakota cities have the most NP jobs?

Sioux Falls, Rapid City, and Huron have the most NP openings in South Dakota right now, with additional roles spread across smaller metros statewide.

Which companies hire NPs in South Dakota?

Employers hiring NPs in South Dakota include Sanford Health, Huron Regional Medical Center, and Sioux Center Health, based on current listings on Migrate Mate as of June 2026.

Are there remote NP jobs in South Dakota?

Yes. About 3% of NP openings tied to South Dakota are remote or hybrid as of June 2026. The rest are on-site roles based in South Dakota metros.

How do I apply for NP jobs in South Dakota?

You can apply to NP jobs in South Dakota directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred South Dakota location, then apply to each one that fits.

See All 34 NP Jobs in South Dakota

Find roles in South Dakota that match your experience and apply in just a few clicks.

Find NP Jobs