Nurse Practitioner Jobs in South Dakota

Nurse Practitioner jobs in South Dakota are open across Sioux Falls, Huron, and Rapid City and other South Dakota metros, with employers like Sanford Health, Huron Regional Medical Center, and Sioux Center Health hiring at every experience level. Find a role that fits below and apply directly.

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Overview

Open roles32+
Top employerSanford Health
Top citySioux Falls, SD
Cities hiring9
Work type100% On-site
Top industryHealthcare

Showing 5 of 32+ Nurse Practitioner jobs

Sanford Health
Nurse Practitioner or Physician Assistant
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Sanford Health
Added 3d ago
Nurse Practitioner or Physician Assistant
Sanford Health
Rapid City, South Dakota
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
Master's
10,000+

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Sanford Health
Nurse Practitioner or Physician Assistant
We won't show you this job again
Sanford Health
Added 5d ago
Nurse Practitioner or Physician Assistant
Sanford Health
Aberdeen, South Dakota
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
Other
10,000+

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Sanford Health
Nurse Practitioner or Physician Assistant
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Sanford Health
Added 6d ago
Nurse Practitioner or Physician Assistant
Sanford Health
Watertown, South Dakota
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
Master's
10,000+

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Sanford Health
Nurse Practitioner or Physician Assistant
We won't show you this job again
Sanford Health
Added 1w ago
Nurse Practitioner or Physician Assistant
Sanford Health
Sioux Falls, South Dakota
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
Master's
10,000+

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Huron Regional Medical Center
Physician Assistant or Nurse Practitioner
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Huron Regional Medical Center
Added 1w ago
Physician Assistant or Nurse Practitioner
Huron Regional Medical Center
Huron, South Dakota
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
None
201-500

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Nurse Practitioner Jobs by City in South Dakota

Where South Dakota roles are concentrated, by current openings.

Sioux Falls
9 jobs
Huron
6 jobs
Rapid City
6 jobs
Aberdeen
4 jobs
Pierre
2 jobs
Sd
2 jobs
Brookings
1 jobs
Watertown
1 jobs
Webster
1 jobs

Nurse Practitioner Job Market in South Dakota

A snapshot from current South Dakota openings, updated as new roles post.

Who's Hiring

  • Sanford Health
    Sanford Health17
  • Huron Regional Medical Center
    Huron Regional Medical Center6
  • Sioux Center Health
    Sioux Center Health5
  • Sanford Bismarck
    Sanford Bismarck2
  • Complete Health
    Complete Health1

Top Industries Hiring

  • Healthcare & Medical Services32
  • Non-Profit & Social Services1

What South Dakota Employers Look For

The qualifications that appear most often in nurse practitioner jobs across South Dakota.

  • Current NP certification from ANCC or AANP in a recognized specialty
  • Active, unencumbered state license as an Advanced Practice Registered Nurse
  • Master of Science in Nursing or Doctor of Nursing Practice degree
  • Current BLS and ACLS certification from the American Heart Association
  • Minimum one to two years of clinical NP or RN experience in a relevant setting
  • Experience with electronic health record systems such as Epic or Cerner

Nurse Practitioner Jobs in South Dakota: Frequently Asked Questions

How many nurse practitioner jobs are there in South Dakota?

There are 32+ nurse practitioner openings in South Dakota on Migrate Mate as of June 2026, with the most roles in Sioux Falls, Huron, and Rapid City. New positions post regularly as employers across South Dakota hire.

How much do nurse practitioners make in South Dakota?

Nurse practitioners in South Dakota earn a median of about $128,840 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $103,080 for the lowest 10% to over $156,000 for the top 10%. Pay rises with experience, specialty, and employer.

Which South Dakota cities have the most nurse practitioner jobs?

Sioux Falls, Huron, and Rapid City have the most nurse practitioner openings in South Dakota right now, with additional roles spread across smaller metros statewide.

Which companies hire nurse practitioners in South Dakota?

Employers hiring nurse practitioners in South Dakota include Sanford Health, Huron Regional Medical Center, and Sioux Center Health, based on current listings on Migrate Mate as of June 2026.

Are there remote nurse practitioner jobs in South Dakota?

Yes. About 0% of nurse practitioner openings tied to South Dakota are remote or hybrid as of June 2026. The rest are on-site roles based in South Dakota metros.

How do I apply for nurse practitioner jobs in South Dakota?

You can apply to nurse practitioner jobs in South Dakota directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred South Dakota location, then apply to each one that fits.

See All 32 Nurse Practitioner Jobs in South Dakota

Find roles in South Dakota that match your experience and apply in just a few clicks.

Find Nurse Practitioner Jobs