Nurse Resident Jobs in South Carolina

Nurse Resident jobs in South Carolina are consistently active, with strong demand driven by hospital systems, academic medical centers, and growing suburban health networks across the state. Most hiring concentrates in Columbia, Charleston, and Greenville, where large employers such as MUSC Health, Prisma Health, and Bon Secours have deep-rooted residency programs. Critical care, medical-surgical, and emergency nursing are the specialties where new-graduate nurse residents are placed most often. Scan the live roles below and apply to whichever ones fit.

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Overview

Open roles61
Top employerPrisma Health
Top cityColumbia, SC
Cities hiring8
Top industryHealthcare

Showing 5 of 61+ Nurse Resident jobs

Prisma Health
Nurse Resident, September 2026, Multispecialty Telemetry
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Prisma Health
Added 2d ago
Nurse Resident, September 2026, Multispecialty Telemetry
Prisma Health
Greenville, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
Bachelor of Science in Nursing
10,000+

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Prisma Health
Registered Nurse (RN) - Nurse Resident, December 2026, Med/Surg
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Prisma Health
Added 2w ago
Registered Nurse (RN) - Nurse Resident, December 2026, Med/Surg
Prisma Health
Columbia, South Carolina
Healthcare Administration
Human Resources
Patient Services & Wellbeing
Bachelor of Science in Nursing
10,000+

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Prisma Health
Registered Nurse- Nurse Resident, September/October 2026, Laurel Oaks, Med/Surg
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Prisma Health
Added 2w ago
Registered Nurse- Nurse Resident, September/October 2026, Laurel Oaks, Med/Surg
Prisma Health
Columbia, South Carolina
Healthcare Administration
Human Resources
Patient Services & Wellbeing
Bachelor of Science in Nursing
10,000+

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Prisma Health
Registered Nurse (RN) - Nurse Resident, December 2026, Accountable Care, Med/Surg Tele
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Prisma Health
Added 2w ago
Registered Nurse (RN) - Nurse Resident, December 2026, Accountable Care, Med/Surg Tele
Prisma Health
Columbia, South Carolina
Customer Service
Customer Support
Hospitality & Guest Services
Bachelor of Science in Nursing
10,000+

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Prisma Health
Registered Nurse (RN) – Nurse Resident, December 2026, Short Stay
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Prisma Health
Added 2w ago
Registered Nurse (RN) – Nurse Resident, December 2026, Short Stay
Prisma Health
Easley, South Carolina
Customer Service
Customer Support
Hospitality & Guest Services
Bachelor of Science in Nursing
10,000+

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Nurse Resident Jobs by City in South Carolina

Where South Carolina roles are concentrated, by current openings.

Sumter
8 jobs
Seneca
6 jobs
Greer
4 jobs
Easley
4 jobs
Clinton
3 jobs
Travelers Rest
2 jobs

Nurse Resident Job Market in South Carolina

A snapshot from current South Carolina openings, updated as new roles post.

Who's Hiring

Prisma Health
Prisma Health61 open roles

Top Industries Hiring

  • Healthcare & Medical Services

What South Carolina Employers Look For

The qualifications that appear most often in nurse resident jobs across South Carolina.

  • Active South Carolina RN license or eligibility through the Nurse Licensure Compact
  • Completion of an accredited associate or bachelor of science in nursing program
  • Passing score on the NCLEX-RN examination before or within residency onboarding
  • Basic Life Support certification from an approved provider prior to start date
  • Commitment to a structured residency program typically lasting twelve months
  • Strong clinical reasoning skills demonstrated through nursing school clinical rotations

Nurse Resident Jobs in South Carolina: Frequently Asked Questions

How do you become a nurse resident in South Carolina?

To become a nurse resident in South Carolina, you must first earn an accredited associate or bachelor of science in nursing degree, then pass the NCLEX-RN and apply for licensure through the South Carolina Board of Nursing. South Carolina participates in the Nurse Licensure Compact, so nurses already licensed in another compact state can work without a separate application. Once licensed, you apply directly to nurse residency programs at hospital systems such as MUSC Health or Prisma Health, which accept new graduates through structured cohort intakes.

Which companies hire nurse residents in South Carolina?

Companies currently hiring nurse residents in South Carolina include Prisma Health, per current listings on Migrate Mate as of August 2026. South Carolina's large integrated health systems, particularly those with teaching hospital affiliations in Columbia and Charleston, post the greatest volume of nurse residency openings throughout the year.

Which South Carolina cities have the most nurse resident jobs?

Columbia, Greenville, and Sumter account for the largest share of nurse resident openings in South Carolina. Columbia leads because of its concentration of state government employees, university medical affiliates, and Prisma Health's flagship facilities, while Charleston's volume is driven by MUSC Health's academic medical campus, and Greenville reflects Bon Secours' expanding regional network in the Upstate.

How can I get hired as a nurse resident in South Carolina with little or no experience?

The most realistic entry path is applying directly to a formal nurse residency program, which is specifically designed for candidates with no post-graduation experience. MUSC Health, Prisma Health, and Bon Secours all run structured new-graduate residency cohorts in South Carolina that provide supervised clinical mentorship for the first year. Candidates who complete clinical rotations at these systems during nursing school have a practical advantage when applying. Holding a current South Carolina RN license or compact equivalency and an ACLS certification alongside BLS strengthens any application before the cohort selection process.

Where can I find and apply to nurse resident jobs in South Carolina?

You can find and apply to nurse resident jobs in South Carolina on Migrate Mate, which lists current openings from employers actively hiring in the state. Search the available roles, identify the ones that match your credentials and preferred location, and apply directly to the ones that fit.

See All 61 Nurse Resident Jobs in South Carolina

Find roles in South Carolina that match your experience and apply in just a few clicks.

Find Nurse Resident Jobs