Nurse Resident Jobs in South Carolina
Nurse Resident jobs in South Carolina are consistently active, with strong demand driven by hospital systems, academic medical centers, and growing suburban health networks across the state. Most hiring concentrates in Columbia, Charleston, and Greenville, where large employers such as MUSC Health, Prisma Health, and Bon Secours have deep-rooted residency programs. Critical care, medical-surgical, and emergency nursing are the specialties where new-graduate nurse residents are placed most often. Scan the live roles below and apply to whichever ones fit.
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Inspire health. Serve with compassion. Be the difference.
Job Summary
Responsible for attending all quality and core curriculum classes, actively participating in professional development workshops and peer support groups, and successfully completing all clinical competencies and validation requirements of the Nurse Residency Program. Works under the direct and indirect supervision of the Clinical Education Team while refining nursing knowledge and skills. Actively participates in managing clinical situations for which he/she is assigned under the direct supervision of a licensed Registered Nurse who oversees all clinical experiences, documentation and procedures in the clinical environment. Adheres to policy and procedure requirements of the organization including, but not limited to licensure renewal, assigned training, employee health screenings, time and attendance policy, dress code policy, patient confidentiality, infection control, medication administration.Essential Functions
All team members are expected to be knowledgeable and compliant with Prisma Health's purpose: Inspire health. Serve with compassion. Be the difference.
Collects patient data and completes required forms with appropriate responses according to unit standards; identifies patient’s problems/needs and sets priorities; identifies problems requiring further referral and/or follow-up; interprets and records latest diagnostic results; performs nursing assessment using critical thinking skills under the direct supervision of the licensed RN.
Develops a plan of care based on nursing process, and which incorporates the plans of other disciplines and continuing care needs; includes the patient/family in developing or revising the plan of care; makes referrals to multidisciplinary support services under the direct supervision of the licensed RN.
Care provided conforms to accepted practice standards; provides treatments/procedures and other care as prescribed and according to patient care standards; demonstrates understanding of age-related characteristics and needs of patients served; explains nursing procedures; provides discharge teaching; identifies emergency situations and independently initiates advanced therapy; acts as an advocate and coordinator of patient care with other health care personnel and evaluates patient care measures instituted; understands and demonstrates respect for patient rights and utilizes established mechanisms for management of ethical issues in patient care under the direct supervision of the licensed RN.
Records patient care delivered as planned and any variation, with appropriate rationale; makes and records observations related to impending or associated problems; implements nursing measures related to impending or associated problems under the direct supervision of the licensed RN.
Using nursing process, delegates nursing care to appropriate personnel; integrates cost effective measures into nursing practice; recognizes unit problems and takes responsibility for documenting same; demonstrates active participation in QI processes; complies with hospital expectations to meet staffing demands based on patient care needs; complies with policies addressing safe working conditions; monitors unsafe working conditions; recognizes inappropriate and/or ineffective patient care management, resolves issue/problem and completes written reports; fulfills call for unit as assigned and adjusts staffing for census (volume) and acuity under the direct supervision of the licensed RN.
Graduate Nurse completes all clinical skills under the direct supervision of a licensed Registered Nurse. Performs other duties as assigned.
Performs other duties as assigned.
Supervisory/Management Responsibility
This is a non-management job that will report to a supervisor, manager, director, or executive.
Minimum Requirements
Education - Associate degree in Nursing. Graduate of an accredited school of Nursing program approved by the State Board of Nursing. Bachelor's degree in Nursing preferred.
Experience - No previous experience is required. Candidates with greater than 12 months of experience are not eligible.
In Lieu Of
In lieu of RN licensure upon hire, a temporary license/Graduate Nurse licensure may be accepted upon receipt of diploma, authorization to test and NCLEX testing date. The Graduate Nurse may work in a provisional status with NCLEX testing date provided prior to hire. The Graduate Nurse works directly under the licensure of the clinical preceptor while in the clinical setting and provides care within the scope of the State Nursing Practice Act provisional status until NCLEX completion with passing score and licensure with State Board of Nursing.
After Jan 1, 2019, all newly hired RN’s at Prisma Health are required to have an ADN or BSN degree from an accredited institution/program recognized by the U.S. Dept. of Education or the State Board of Nursing.
Required Certifications, Registrations, Licenses
Holds a current RN compact/multistate license recognized by the NCSBN Compact State or is licensed to practice as an RN in the state the team member is working.
Knowledge, Skills and Abilities
NA
Work Shift
Variable (United States of America)Location
Greenville Memorial HospitalFacility
Greenville Memorial HospitalDepartment
Multispecialty TelemetryShare your talent with us! Our vision is simple: to transform healthcare for the benefits of the communities we serve. The transformation of healthcare requires talented individuals in every role here at Prisma Health.
See All 61 Nurse Resident Jobs in South Carolina
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Find Nurse Resident JobsNurse Resident Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
Nurse Resident Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring

Top Industries Hiring
- Healthcare & Medical Services
What South Carolina Employers Look For
The qualifications that appear most often in nurse resident jobs across South Carolina.
- Active South Carolina RN license or eligibility through the Nurse Licensure Compact
- Completion of an accredited associate or bachelor of science in nursing program
- Passing score on the NCLEX-RN examination before or within residency onboarding
- Basic Life Support certification from an approved provider prior to start date
- Commitment to a structured residency program typically lasting twelve months
- Strong clinical reasoning skills demonstrated through nursing school clinical rotations
Nurse Resident Jobs in South Carolina: Frequently Asked Questions
How do you become a nurse resident in South Carolina?
To become a nurse resident in South Carolina, you must first earn an accredited associate or bachelor of science in nursing degree, then pass the NCLEX-RN and apply for licensure through the South Carolina Board of Nursing. South Carolina participates in the Nurse Licensure Compact, so nurses already licensed in another compact state can work without a separate application. Once licensed, you apply directly to nurse residency programs at hospital systems such as MUSC Health or Prisma Health, which accept new graduates through structured cohort intakes.
Which companies hire nurse residents in South Carolina?
Companies currently hiring nurse residents in South Carolina include Prisma Health, per current listings on Migrate Mate as of August 2026. South Carolina's large integrated health systems, particularly those with teaching hospital affiliations in Columbia and Charleston, post the greatest volume of nurse residency openings throughout the year.
Which South Carolina cities have the most nurse resident jobs?
Columbia, Greenville, and Sumter account for the largest share of nurse resident openings in South Carolina. Columbia leads because of its concentration of state government employees, university medical affiliates, and Prisma Health's flagship facilities, while Charleston's volume is driven by MUSC Health's academic medical campus, and Greenville reflects Bon Secours' expanding regional network in the Upstate.
How can I get hired as a nurse resident in South Carolina with little or no experience?
The most realistic entry path is applying directly to a formal nurse residency program, which is specifically designed for candidates with no post-graduation experience. MUSC Health, Prisma Health, and Bon Secours all run structured new-graduate residency cohorts in South Carolina that provide supervised clinical mentorship for the first year. Candidates who complete clinical rotations at these systems during nursing school have a practical advantage when applying. Holding a current South Carolina RN license or compact equivalency and an ACLS certification alongside BLS strengthens any application before the cohort selection process.
Where can I find and apply to nurse resident jobs in South Carolina?
You can find and apply to nurse resident jobs in South Carolina on Migrate Mate, which lists current openings from employers actively hiring in the state. Search the available roles, identify the ones that match your credentials and preferred location, and apply directly to the ones that fit.
See All 61 Nurse Resident Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find Nurse Resident Jobs