Nurse Resident Jobs in South Carolina
Nurse Resident jobs in South Carolina are consistently active, with strong demand driven by hospital systems, academic medical centers, and growing suburban health networks across the state. Most hiring concentrates in Columbia, Charleston, and Greenville, where large employers such as MUSC Health, Prisma Health, and Bon Secours have deep-rooted residency programs. Critical care, medical-surgical, and emergency nursing are the specialties where new-graduate nurse residents are placed most often. Scan the live roles below and apply to whichever ones fit.
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Inspire health. Serve with compassion. Be the difference.
Job Summary
Responsibility of attending all quality and core curriculum classes, actively participating in professional development workshops and peer support groups, and successfully completing all clinical competencies and validation requirements of the Nurse Residency Program. Works under the direct and indirect supervision of the Clinical Education Team while refining nursing knowledge and skills. Actively participates in managing clinical situations for which he/she is assigned under the direct supervision of a licensed Registered Nurse who oversees all clinical experiences, documentation and procedures in the clinical environment.Adheres to policy and procedure requirements of the organization including, but not limited to licensure renewal, assigned training, employee health screenings, time and attendance policy, dress code policy, patient confidentiality, infection control, medication administration.
Service Line: Adult Multispecialty
Facility: Oconee Memorial Hospital (Seneca, SC)
Dept: Surgical Specialty
Essential Functions
All team members are expected to be knowledgeable and compliant with Prisma Health's purpose: Inspire health. Serve with compassion. Be the difference.
Collects patient data and completes required forms with appropriate responses according to unit standards; identifies patient’s problems/needs and communicates with the RN; reviews and records latest diagnostic results; performs patient care under the direct supervision of the licensed RN.
Participates in the interdisciplinary care team to provide input on the plan of care based on nursing process and which incorporates the plans of other disciplines and continuing care needs; makes referrals to multidisciplinary support services under the direct supervision of the licensed RN.
Care provided conforms to accepted practice standards; provides treatments/procedures and other care as prescribed and according to patient care standards; demonstrates understanding of age-related characteristics and needs of patients served; explains nursing procedures; provides discharge teaching; identifies emergency situations and escalates to the RN; acts as an advocate for patient care with other health care personnel and evaluates patient care measures instituted; understands and demonstrates respect for patient rights and utilizes established mechanisms for management of ethical issues in patient care under the direct supervision of the licensed RN.
Records patient care delivered as planned and any variation, with appropriate rationale; makes and records observations related to impending or associated problems; implements nursing measures related to impending or associated problems under the direct supervision of the licensed RN.
Integrates cost effective measures into nursing practice; recognizes unit problems and takes responsibility for escalating to the RN; demonstrates active participation in QI processes; complies with hospital expectations to meet staffing demands based on patient care needs; complies with policies addressing safe working conditions; monitors unsafe working conditions; recognizes inappropriate and/or ineffective patient care management, resolves issue/problem and completes written reports; fulfils call for unit as assigned and adjusts staffing for census (volume) and acuity under the direct supervision of the licensed RN.
Performs other duties as assigned.
Supervisory/Management Responsibilities
This is a non-management job that will report to a supervisor, manager, director or executive.
Minimum Requirements
Education - Completion of an LPN program recognized by the State Board of Nursing.
Experience - Candidates with greater than twelve (12) months LPN experience are not eligible to participate.
In Lieu Of
In lieu of completion of a LPN program, will accept program equivalency recognized by the State Board of Nursing.
Required Certifications, Registrations, Licenses
Holds a current LPN compact/multistate license recognized by the NCSBN Compact State or is licensed to practice as an LPN in the state the team member is working.
If an LPN team member working in this position obtains RN licensure, Prisma Health will accept RN licensure for a limited time until the team member can be placed in an RN position. Team members should immediately notify their manager and Talent Acquisition if they are scheduled to sit for the NCLEX-RN exam or have obtained RN licensure.
Knowledge, Skills and Abilities
NA
Work Shift
Variable (United States of America)Location
Oconee Medical CampusFacility
Oconee Memorial HospitalDepartment
Surgical SpecialtyShare your talent with us! Our vision is simple: to transform healthcare for the benefits of the communities we serve. The transformation of healthcare requires talented individuals in every role here at Prisma Health.
See All 42 Nurse Resident Jobs in South Carolina
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Find Nurse Resident JobsNurse Resident Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
Nurse Resident Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring

Top Industries Hiring
- Healthcare & Medical Services
What South Carolina Employers Look For
The qualifications that appear most often in nurse resident jobs across South Carolina.
- Active South Carolina RN license or eligibility through the Nurse Licensure Compact
- Completion of an accredited associate or bachelor of science in nursing program
- Passing score on the NCLEX-RN examination before or within residency onboarding
- Basic Life Support certification from an approved provider prior to start date
- Commitment to a structured residency program typically lasting twelve months
- Strong clinical reasoning skills demonstrated through nursing school clinical rotations
Nurse Resident Jobs in South Carolina: Frequently Asked Questions
How do you become a nurse resident in South Carolina?
To become a nurse resident in South Carolina, you must first earn an accredited associate or bachelor of science in nursing degree, then pass the NCLEX-RN and apply for licensure through the South Carolina Board of Nursing. South Carolina participates in the Nurse Licensure Compact, so nurses already licensed in another compact state can work without a separate application. Once licensed, you apply directly to nurse residency programs at hospital systems such as MUSC Health or Prisma Health, which accept new graduates through structured cohort intakes.
Which companies hire nurse residents in South Carolina?
Companies currently hiring nurse residents in South Carolina include Prisma Health, per current listings on Migrate Mate as of October 2026. South Carolina's large integrated health systems, particularly those with teaching hospital affiliations in Columbia and Charleston, post the greatest volume of nurse residency openings throughout the year.
Which South Carolina cities have the most nurse resident jobs?
Columbia, Seneca, and Sumter account for the largest share of nurse resident openings in South Carolina. Columbia leads because of its concentration of state government employees, university medical affiliates, and Prisma Health's flagship facilities, while Charleston's volume is driven by MUSC Health's academic medical campus, and Greenville reflects Bon Secours' expanding regional network in the Upstate.
Are there remote nurse resident jobs in South Carolina?
Yes, but they're rare. Nurse residency roles are fundamentally hands-on positions requiring in-person patient care, so the vast majority require on-site work. About 0% of nurse resident openings tied to South Carolina are remote or hybrid as of October 2026, and those exceptions typically cover care coordination, telephonic triage, or population health components embedded within a residency track rather than fully bedside-free positions.
How can I get hired as a nurse resident in South Carolina with little or no experience?
The most realistic entry path is applying directly to a formal nurse residency program, which is specifically designed for candidates with no post-graduation experience. MUSC Health, Prisma Health, and Bon Secours all run structured new-graduate residency cohorts in South Carolina that provide supervised clinical mentorship for the first year. Candidates who complete clinical rotations at these systems during nursing school have a practical advantage when applying. Holding a current South Carolina RN license or compact equivalency and an ACLS certification alongside BLS strengthens any application before the cohort selection process.
Where can I find and apply to nurse resident jobs in South Carolina?
You can find and apply to nurse resident jobs in South Carolina on Migrate Mate, which lists current openings from employers actively hiring in the state. Search the available roles, identify the ones that match your credentials and preferred location, and apply directly to the ones that fit.
See All 42 Nurse Resident Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find Nurse Resident Jobs