Program Assistant Jobs in South Carolina
Program Assistant jobs in South Carolina are concentrated in Columbia, Charleston, and Greenville, where state government agencies, major health systems, and research universities drive consistent demand for program support roles in administration, public health, and higher education. Employers such as the Medical University of South Carolina, Prisma Health, and the South Carolina Department of Health and Environmental Control maintain a steady need for program assistants at both entry and mid-career levels. Demand is especially strong in grant administration, community health outreach, and government program coordination. Scan the live roles below and apply to whichever ones fit.
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Active Day has several opportunities for Program Assistant / PCA / Activities Assistant
No Experience - No Problem!
As long as you have PASSION, DEDICATION AND A DRIVE to serve others-
We will train you!
**Full-Time**
As a Program Assistant/Activities Assistant, you will provide loving care and assistance to our members by helping them with activities, personal and medical care, meals, and on and off-site social activities. Yes, our Program Assistants are most definitely ACTIVE!! Our Program Assistants are always smiling and creating a warm and welcoming environment, all while ensuring our members are safe, happy, and well.
As part of our team, you will have the opportunity to participate in benefits programs, including:
- Paid Time Off (“PTO”)
- Medical/Vision
- Dental
- 401(k)
- And the pleasure of working in a FUN environment with GREAT people!
Program Assistants participate in the planning and facilitation of individual and group therapeutic recreational programs that meet the needs and interests of our members. Program Assistants assist individual members with activities of daily living as needed, serve meals and snacks, and help to maintain a clean, orderly and uplifting environment. Our team members are expected to lead by example - maintaining a positive attitude; being a thoughtful, supportive, productive and dependable co-worker; keeping our members safe; and always working to enhance the health and happiness of the people we serve and those who care for them.
Qualifications
- High school diploma or equivalent strongly preferred or a minimum of two (2) years relevant experience.
- At least one-year full-time equivalent experience in a health care setting preferred.
- Prior experience working seniors and/or adults with special needs preferred but not required
- Engaging interpersonal and communication skills.
- Able to multi-task and manage time effectively.
- Able to work a flexible schedule.
- Able to bend, pull, push, squat, turn, transfer, and lift 50 pounds; able to stand for an extended period while providing physical assistance to members
- Successful results of background check, and where applicable, additional state-specific regulatory requirements.
- Assist members with activities of daily living and personal care as needed (e.g. arrival and departure, eating, ambulation, transferring, therapies, rest room assistance, etc.).
- Assist in the planning and facilitation of creative and diverse therapeutic recreational programs and encourage member participation.
- Serve meals and snacks and clear tables; assist with feeding as needed.
- Observe members for change in condition or unusual occurrences. Escalate concerns as appropriate.
- Maintain program areas, supplies, and equipment ensuring all are clean, disinfected, stocked, replenished and in good working order.
- Ensure the safety of members by monitoring activities, keeping a sanitary, clutter-free environment, and participating in safety training; actively contribute to creating and maintaining a clean, orderly, bright and welcoming center.
- Communicate in a positive, courteous and professional manner with members and their families, co-workers, referral agencies, and the community at large.
- Participate in staff meetings and in-service educational programs as requested; actively collaborate with cross-functional team, providing feedback and recommendations for enhancing the member experience and achieving the center’s overall goals and objectives.
- Comply with company policies and procedures, safety and regulatory laws and standards.
- Other duties and responsibilities as changed or assigned at any time.
See All 26 Program Assistant Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find Program Assistant JobsProgram Assistant Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
Program Assistant Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring
- State of South Carolina12

- Active Day4

- YMCA1

- ECPI University1

- Grow Early Learning1

Top Industries Hiring
- Education
What South Carolina Employers Look For
The qualifications that appear most often in program assistant jobs across South Carolina.
- Associate or bachelor's degree in a relevant field from an accredited institution
- Experience coordinating programs or providing administrative support in an office setting
- Proficiency with Microsoft Office Suite including Word, Excel, and Outlook
- Strong written and verbal communication skills for internal and external stakeholders
- Ability to manage multiple deadlines and prioritize tasks in a fast-paced environment
- Familiarity with data entry, recordkeeping, and reporting procedures
Program Assistant Jobs in South Carolina: Frequently Asked Questions
How do you become a program assistant in South Carolina?
Most program assistant roles in South Carolina require at minimum an associate degree, though many employers prefer a bachelor's degree in public administration, health sciences, business, or a related field. There is no state-issued license specific to the program assistant title, but roles within state agencies often require a background check and completion of South Carolina state onboarding requirements. Starting in agency support, nonprofit administration, or a university department coordinator role is the most common entry path in this state.
Which companies hire program assistants in South Carolina?
Companies currently hiring program assistants in South Carolina include State of South Carolina, Active Day, and YMCA, per current listings on Migrate Mate as of September 2026. South Carolina's concentration of state government agencies, academic medical centers, and federally funded research institutions makes it one of the more active markets for ongoing program assistant openings.
Which South Carolina cities have the most program assistant jobs?
Richland County, Lexington County, and Greenville County have the most program assistant openings in South Carolina. Columbia leads because it is the state capital and home to the University of South Carolina and numerous state agencies, while Charleston's growth in healthcare and higher education through MUSC drives demand there, and Greenville's expanding corporate and healthcare base supports steady openings in the Upstate region.
Are there remote program assistant jobs in South Carolina?
Yes, but they are less common than in purely desk-based fields, since many program assistant roles involve in-person coordination, filing, and stakeholder meetings. About 33% of program assistant openings tied to South Carolina are remote or hybrid as of September 2026, with the most flexibility found in grant administration and data-focused program support roles rather than direct service coordination positions.
How can I get hired as a program assistant in South Carolina with little or no experience?
The most realistic entry path is applying to administrative coordinator or program support associate postings at South Carolina state agencies, the University of South Carolina system, or Prisma Health, all of which regularly post roles open to recent graduates. A completed internship with a South Carolina nonprofit or government office, combined with demonstrated experience in scheduling and data entry, gives candidates a strong edge. Pursuing a certificate in project management or public administration strengthens applications for competitive agency roles.
Where can I find and apply to program assistant jobs in South Carolina?
You can find and apply to program assistant jobs in South Carolina on Migrate Mate, which lists current South Carolina openings updated regularly. Search the listings to find roles that match your experience and location, then apply directly to the ones that fit. No profile creation is required to view or apply to openings.
See All 26 Program Assistant Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
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