Medical Director Jobs in USA with Visa Sponsorship
Medical Directors lead clinical operations, quality initiatives, and physician teams at hospitals, health systems, and healthcare organizations. Most positions require H-1B sponsorship for international candidates, with EB-2 green card pathways available for experienced physicians. The role typically requires board certification and several years of clinical experience. For detailed occupation requirements, see the O*NET profile.
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General Summary: The Clinical Development Associate Medical Director will serve as the Medical Lead for clinical trials, working with cross-functional teams on trial strategy, design, execution, and reporting. In addition to oversight and accountability for the study as a whole, this role will serve as the internal primary Medical Monitor accountable for monitoring the safety of enrolled subjects and ensuring scientific integrity. The incumbent may participate in other projects to support the clinical development program.
Key Duties And Responsibilities
- Participates in the development of Study Protocols, Investigator's Brochures, Clinical Development Plans and other key documents in conjunction with other line functions and with minimal guidance
- Serves on cross-functional Study Execution Teams (SET) for assigned trials, working with other team members to achieve efficient, high-quality study execution
- Participates in the preparation of regulatory documents in support of regulatory submissions, including clinical section of INDs and CTAs, IND safety reports and annual reports for assigned trials, responses to regulatory authorities and Ethics Committees/IRBs, and other documents as appropriate
- Provides scientific and clinical input to study-related documents and analysis plans including informed consent forms, clinical research forms, statistical analysis plans, clinical pharmacology analysis plans, and clinical study reports
- Acts as liaison between Clinical Development and other internal groups at Vertex (e.g., Regulatory Affairs, Clinical Development Execution) for assigned studies
- Represents Vertex to outside medical personnel in the development of clinical protocols, in study conduct, and in external reporting of study results
- Performs other duties as assigned related to other aspects of Clinical Development
Knowledge And Skills
- Strong oral and written communication skills
- Ability to work collaboratively in a fast-paced, team-based matrix environment and to function independently as appropriate
- Global clinical research experience and experience interacting with regulatory authorities is a plus
- Working familiarity with analysis of research data, biostatistics, pharmacology and pharmacokinetics, international standards for Good Clinical Practice (GCP), clinical study design, ethics committee/Institutional Review Board review, preparation of manuscripts, abstract/posters, and oral presentations, overall drug/device clinical development
- Board certification/eligibility, as well as clinical training in a relevant medical specialty is highly desired
Education And Experience
- MD, DO or equivalent ex-US medical degree
- Typically requires 8 years of basic or clinical research experience in an academic or industry setting, or the equivalent combination of education and experience
Pay Range
$204,000 - $306,000
Disclosure Statement
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
Flex Designation
Hybrid-Eligible Or On-Site Eligible
Flex Eligibility Status
In this Hybrid-Eligible role, you can choose to be designated as:
- Hybrid: work remotely up to two days per week; or select
- On-Site: work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.
Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com
Job Description
General Summary: The Clinical Development Associate Medical Director will serve as the Medical Lead for clinical trials, working with cross-functional teams on trial strategy, design, execution, and reporting. In addition to oversight and accountability for the study as a whole, this role will serve as the internal primary Medical Monitor accountable for monitoring the safety of enrolled subjects and ensuring scientific integrity. The incumbent may participate in other projects to support the clinical development program.
Key Duties And Responsibilities
- Participates in the development of Study Protocols, Investigator's Brochures, Clinical Development Plans and other key documents in conjunction with other line functions and with minimal guidance
- Serves on cross-functional Study Execution Teams (SET) for assigned trials, working with other team members to achieve efficient, high-quality study execution
- Participates in the preparation of regulatory documents in support of regulatory submissions, including clinical section of INDs and CTAs, IND safety reports and annual reports for assigned trials, responses to regulatory authorities and Ethics Committees/IRBs, and other documents as appropriate
- Provides scientific and clinical input to study-related documents and analysis plans including informed consent forms, clinical research forms, statistical analysis plans, clinical pharmacology analysis plans, and clinical study reports
- Acts as liaison between Clinical Development and other internal groups at Vertex (e.g., Regulatory Affairs, Clinical Development Execution) for assigned studies
- Represents Vertex to outside medical personnel in the development of clinical protocols, in study conduct, and in external reporting of study results
- Performs other duties as assigned related to other aspects of Clinical Development
Knowledge And Skills
- Strong oral and written communication skills
- Ability to work collaboratively in a fast-paced, team-based matrix environment and to function independently as appropriate
- Global clinical research experience and experience interacting with regulatory authorities is a plus
- Working familiarity with analysis of research data, biostatistics, pharmacology and pharmacokinetics, international standards for Good Clinical Practice (GCP), clinical study design, ethics committee/Institutional Review Board review, preparation of manuscripts, abstract/posters, and oral presentations, overall drug/device clinical development
- Board certification/eligibility, as well as clinical training in a relevant medical specialty is highly desired
Education And Experience
- MD, DO or equivalent ex-US medical degree
- Typically requires 8 years of basic or clinical research experience in an academic or industry setting, or the equivalent combination of education and experience
Pay Range
$204,000 - $306,000
Disclosure Statement
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
Flex Designation
Hybrid-Eligible Or On-Site Eligible
Flex Eligibility Status
In this Hybrid-Eligible role, you can choose to be designated as:
- Hybrid: work remotely up to two days per week; or select
- On-Site: work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.
Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com
How to Get Visa Sponsorship in Medical Director
Target academic medical centers and large health systems
Major healthcare institutions like Mayo Clinic, Cleveland Clinic, and university hospitals regularly sponsor H-1B visas for physician leadership roles and have established immigration processes.
Emphasize your dual clinical and administrative experience
Medical Director roles require both clinical expertise and management skills. Highlight experience leading quality initiatives, managing budgets, or supervising physician teams in your applications.
Board certification is typically mandatory for sponsorship
Most employers require current board certification in your specialty plus valid medical licensure. International physicians may need ECFMG certification and completion of U.S. residency training.
Consider physician shortage areas for faster processing
Rural hospitals and underserved areas often qualify for expedited processing through physician shortage waivers, potentially reducing both H-1B and green card timelines significantly.
Document your quality improvement and leadership achievements
Prepare specific examples of clinical outcomes you've improved, cost savings achieved, or successful physician recruitment efforts to strengthen your H-1B specialty occupation case.
Explore J-1 to H-1B pathways if you're completing fellowship
Physicians finishing fellowship training on J-1 visas can transition to Medical Director roles through H-1B sponsorship, though J-1 waiver requirements may apply.
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Get Access To All JobsFrequently Asked Questions
Do Medical Director positions qualify for H-1B sponsorship?
Yes, Medical Director roles typically qualify as specialty occupations requiring a medical degree and board certification. The combination of clinical expertise and administrative responsibilities meets H-1B specialty occupation requirements. Most major healthcare systems regularly sponsor these positions.
What degree requirements do employers expect for Medical Director sponsorship?
Employers require an MD or equivalent medical degree, plus board certification in a relevant specialty. Many positions also prefer MBA or healthcare administration credentials. International medical degrees must be verified through ECFMG, and U.S. residency completion is typically required.
How competitive is H-1B sponsorship for Medical Director roles?
Medical Director positions have strong H-1B approval rates due to clear specialty occupation requirements and critical healthcare needs. However, competition exists among qualified candidates, and board certification plus management experience significantly strengthen applications.
Can Medical Directors get green cards through their employers?
Yes, Medical Directors typically qualify for EB-2 green cards based on advanced degrees and professional experience. Some may qualify for EB-1B if they demonstrate outstanding achievement in medicine. Physicians in underserved areas may access expedited processing options.
Do Medical Directors need state medical licenses for visa sponsorship?
Most employers require active medical licensure in the state where you'll work, or eligibility to obtain licensure. Some positions may allow you to start the licensing process after H-1B approval, but having current licensure strengthens your application significantly.
What is the prevailing wage requirement for sponsored Medical Director jobs?
U.S. employers sponsoring a visa must pay at least the prevailing wage, which is what workers in the same role, area, and experience level typically earn. The Department of Labor sets this rate to make sure companies aren't hiring foreign workers simply because they'd accept lower pay than a U.S. worker. It varies by job title, location, and experience. You can look up current prevailing wage rates for any occupation and location using the OFLC Wage Search page.
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