Advanced Practice Provider Jobs in California
Advanced Practice Provider jobs in California are among the most active in the nation, concentrated in hospital systems, integrated health networks, outpatient specialty clinics, and community health centers, with openings at every level from new-graduate NPs and PAs through senior and lead clinical positions. The highest volume of hiring is in Los Angeles, the San Francisco Bay Area, and San Diego, where employers like Kaiser Permanente, Dignity Health, and UCSF Health maintain large and ongoing advanced practice provider pipelines. The most in-demand specialties across the state are primary care, urgent care, oncology, and behavioral health. Find a role that fits below and apply directly.
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Build the Future of Research
InvivoCure is growing quickly
We are seeking an experienced Nurse Practitioner or Physician Assistant to join our team in Van Nuys. Spanish-fluency is a must. Cardiology experience is a big plus. This important position combines the challenge of clinical research with meaningful continuity of care in cardiology.
Approximately 75% of the role will support industry-sponsored clinical trials as a Sub-Investigator, working under the Principal Investigator’s oversight and within the practitioner’s licensure, training, protocol delegation, and site procedures. The remaining 25% will provide clinical and hospital coverage for our cardiologist Principal Investigator, helping patients receive responsive, coordinated care across settings.
What You Will Do
Clinical Research — Approximately 75%
- Protect participant rights, safety, and well-being while helping conduct trials in accordance with the protocol, Good
- Clinical Practice, applicable regulations, IRB requirements, and InvivoCure procedures.
- Perform protocol-delegated clinical activities such as medical-history review, physical examinations, eligibility assessments, study visits, review of laboratory and diagnostic results, and clinical decision-making.
- Assess and document adverse events, serious adverse events, concomitant medications, medical history, and changes in participant status; escalate and report safety information promptly.
- Support the informed-consent process when delegated, confirm participant understanding, and answer clinical questions within scope.
- Complete timely, accurate, attributable source documentation and respond to clinical data queries in collaboration with coordinators, the PI, sponsors, CROs, monitors, and other study partners.
- Administer or oversee investigational products, injections, and infusion-related procedures when permitted by protocol, training, licensure, and competency.
- Participate in site initiation visits, monitoring visits, audits, investigator meetings, protocol training, recruitment planning, and team huddles.
- Help strengthen clinical workflows, quality systems, technology adoption, and a culture of continuous improvement as InvivoCure expands.
Cardiology Practice Coverage — Approximately 25%
- Provide outpatient cardiology and internal-medicine support for established and new patients within scope and under the applicable collaboration or practice arrangement.
- Obtain focused histories, perform examinations, develop assessments and plans, order and interpret appropriate testing, reconcile medications, and provide patient education.
- Assist with hospital rounding, consultations, follow-up, transitions of care, and clinical documentation as scheduled with the cardiologist PI.
- Communicate clearly with patients, families, nursing teams, pharmacies, specialists, and hospital personnel in English and Spanish.
- Maintain timely documentation and support appropriate coding, follow-up, and care coordination.
What You Bring
Required
- Current, unrestricted California licensure as a Nurse Practitioner or Physician Assistant, with all credentials required to practice and prescribe or furnish medications within the role’s scope.
- Graduate of an accredited NP or PA program; current national certification appropriate to the practitioner’s discipline and population focus.
- Mid-level professional experience, ideally three or more years of post-training clinical practice.
- Professional Spanish proficiency sufficient to conduct patient interviews, explain care and research procedures, and support informed communication.
- Ability to obtain or maintain ACLS, DEA registration, hospital privileges, payer enrollment, and study-specific credentials as required.
- Excellent clinical judgment, documentation, communication, organization, and follow-through.
- Ability to work primarily in Van Nuys and travel occasionally to InvivoCure sites in the region and domestic investigator meetings.
Highly Valued
- Clinical research experience, including work as a Sub-Investigator, investigator, research clinician, or trial-site provider.
- Knowledge of ICH Good Clinical Practice, FDA-regulated research, informed consent, safety reporting, source documentation, and protocol compliance.
- Infusion-therapy experience, including patient assessment, vascular access familiarity, medication administration, reaction recognition, and emergency response.
- Technological confidence with electronic health records, clinical trial management systems, electronic data capture, eSource, electronic regulatory systems, mobile devices, and video collaboration.
- Experience in hospital cardiology, internal medicine, heart failure, arrhythmia, hypertension, dyslipidemia, preventive cardiology, or cardiometabolic care.
- A builder’s mindset: adaptable, collaborative, quality-focused, and energized by creating scalable systems in a rapidly growing organization.
How You Will Succeed
- Participant and patient safety comes first.
- Clinical decisions and documentation are accurate, timely, and protocol-aligned.
- The PI, coordinators, and clinical team can rely on clear communication and dependable coverage.
- Sponsors and partners experience InvivoCure as responsive, organized, technologically capable, and inspection-ready.
- You help improve—not merely inherit—our workflows as the company grows.
What We Offer
- Base salary of $160,000–$190,000 per year for this full-time W-2 position. The final offer will reflect relevant cardiology and research experience, credentials, Spanish proficiency, hospital responsibilities, schedule, and internal equity.
- Competitive benefits package, paid time off, and professional-development support, subject to plan terms and company policy.
- Exposure to innovative, industry-sponsored research and the opportunity to help shape a fast-growing clinical research organization.
- A modern, collaborative environment co-located with the cardiology and internal-medicine practice of our Principal Investigator and Co-Founder, Rodney Samaan, MD, MPH.
- A mission-driven team that values excellent care, strong execution, curiosity, accountability, and respect.
About InvivoCure
InvivoCure is an independent clinical research organization headquartered in Van Nuys, California. We conduct industry-sponsored clinical trials designed to advance medical knowledge and help people live healthier lives. Our team combines compassionate participant care with disciplined research execution, and we are investing in the people, technology, and systems needed for our next stage of growth.
If you are a clinically strong, bilingual advanced practice provider who wants to expand the reach of innovative research while remaining connected to patient care, we would be excited to meet you.
Pay: $160,000.00 - $190,000.00 per year
Benefits:
- 401(k)
- Dental insurance
- Health insurance
- Paid time off
Work Location: In person
See All 70 Advanced Practice Provider Jobs in California
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Where California roles are concentrated, by current openings.
Advanced Practice Provider Job Market in California
A snapshot from current California openings, updated as new roles post.
Who's Hiring



Top Industries Hiring
- Education
- Insurance
- Healthcare & Medical Services
What California Employers Look For
The qualifications that appear most often in advanced practice provider jobs across California.
- Active California NP or PA license issued by the California Medical Board or Board of Registered Nursing
- National board certification such as ANCC, AANPCP, or NCCPA appropriate to the specialty
- Master's or doctoral degree in nursing or physician assistant studies from an accredited program
- Current DEA registration and California furnishing number for roles with prescriptive authority
- BLS and ACLS certification current at time of hire or within specified onboarding period
- Minimum one to three years of clinical experience in the relevant specialty or patient population
Advanced Practice Provider Jobs in California: Frequently Asked Questions
How do you become a advanced practice provider in California?
Nurse practitioners must obtain licensure through the California Board of Registered Nursing, which requires completing an accredited graduate-level NP program and passing a national board certification exam such as the ANCC or AANPCP. Physician assistants are licensed by the Physician Assistant Board of California after graduating from an accredited PA program and passing the PANCE. California also requires a separate furnishing number through the BRN or PAB for prescriptive authority, and ongoing continuing education to maintain licensure.
How much do advanced practice providers make in California?
Advanced practice providers in California earn a median of about $168,520 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $120,340 for the lowest 10% to over $240,830 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire advanced practice providers in California?
Employers hiring advanced practice providers in California right now include Unio Health Partners, Family HealthCare Network, and Cottage Health, based on current listings on Migrate Mate as of October 2026. California's large integrated systems and community health networks tend to post consistently throughout the year, making them reliable targets for ongoing applications.
Which California cities have the most advanced practice provider jobs?
Fresno, San Diego, and Redding have the most advanced practice provider openings in California. Los Angeles and the Bay Area lead because of their dense concentration of academic medical centers, large integrated health systems, and specialty group practices, while San Diego's strong research hospital and military-affiliated healthcare sector sustains consistent demand outside the two primary metros.
Are there remote advanced practice provider jobs in California?
Yes, but they're rare. Advanced practice provider work is inherently hands-on and the vast majority of roles require in-person patient care. About 13% of advanced practice provider openings tied to California are remote or hybrid as of October 2026, and those positions are almost exclusively in telehealth triage, chronic disease management, or utilization review rather than direct procedural or acute care.
How can I get hired as a advanced practice provider in California with little or no experience?
The most realistic entry path is a new-graduate residency or fellowship program, and California has some of the country's most established options. Kaiser Permanente, UCSF Health, and the VA Greater Los Angeles Healthcare System run structured NP and PA residencies that are specifically designed for candidates without post-graduate clinical hours. Candidates who begin in a registered nurse or medical assistant role at a large California system often transition internally once they complete their advanced practice degree. A completed California furnishing number and at least one specialty board certification give new graduates a meaningful edge in a competitive pool.
Where can I find and apply to advanced practice provider jobs in California?
You can find and apply to advanced practice provider jobs in California on Migrate Mate, which lists current California openings across hospital systems, outpatient clinics, and specialty practices. Find roles that fit your specialty and experience level and apply directly.
See All 70 Advanced Practice Provider Jobs in California
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