Clinical Registered Nurse Jobs in Iowa
Clinical Registered Nurse jobs in Iowa are concentrated in acute care hospitals, long-term care, and outpatient clinic settings, with steady demand at every level from new graduates to experienced charge nurses. The heaviest hiring activity is in Des Moines, Iowa City, and Cedar Rapids, where large systems like UnityPoint Health, University of Iowa Health Care, and MercyOne are among the most active employers in the state. Critical care, med-surg, and pediatrics are the specialties generating the most consistent openings across Iowa. See the openings below and apply to the ones that match your experience.
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Showing 5 of 31+ Clinical Registered Nurse jobs
Where Nursing Meets Technology—and Better Care Starts With You!
Are you an RN who loves both patient care and problem-solving? Join our team as a Clinical Informatics Specialist and help bridge the gap between clinical practice and technology. In this role, you’ll use your nursing expertise to improve workflows, support clinical systems, and empower caregivers with the tools they need to provide exceptional patient care.
At UnityPoint Health, you matter. We’re proud to be recognized as a Top 150 Place to Work in Healthcare by Becker's Healthcare several years in a row for our commitment to our team members.
Our competitive Total Rewards program offers benefits options that align with your needs and priorities, no matter what life stage you’re in. Here are just a few:
- Expect paid time off, parental leave, 401K matching and an employee recognition program.
- Dental and health insurance, paid holidays, short and long-term disability and more. We even offer pet insurance for your four-legged family members.
- Early access to earned wages with Daily Pay, tuition reimbursement to help further your career and adoption assistance to help you grow your family.
With a collective goal to champion a culture of belonging where everyone feels valued and respected, we honor the ways people are unique and embrace what brings us together.
And, we believe equipping you with support and development opportunities is a vital part of delivering an exceptional employment experience.
Find a fulfilling career and make a difference with UnityPoint Health.
Responsibilities:- Partner with nurses, providers, and clinical teams to improve workflows and processes.
- Serve as a clinical expert for electronic health records and other healthcare technology.
- Identify opportunities to improve patient safety, quality, efficiency, and the overall care experience.
- Support system implementations, upgrades, testing, troubleshooting, and optimization.
- Develop and provide education and training to clinical staff on technology and system changes.
- Analyze clinical data and system functionality to identify trends and recommend improvement
- Graduate of an accredited nursing program (must obtain BSN within 12 years of hire date)
Experience:
- (3) three years of prior experience using EPIC EMR
License/Certification:
- Current licensure in good standing to practice as a Registered Nurse in Iowa
Where Nursing Meets Technology—and Better Care Starts With You!
Are you an RN who loves both patient care and problem-solving? Join our team as a Clinical Informatics Specialist and help bridge the gap between clinical practice and technology. In this role, you’ll use your nursing expertise to improve workflows, support clinical systems, and empower caregivers with the tools they need to provide exceptional patient care.
At UnityPoint Health, you matter. We’re proud to be recognized as a Top 150 Place to Work in Healthcare by Becker's Healthcare several years in a row for our commitment to our team members.
Our competitive Total Rewards program offers benefits options that align with your needs and priorities, no matter what life stage you’re in. Here are just a few:
- Expect paid time off, parental leave, 401K matching and an employee recognition program.
- Dental and health insurance, paid holidays, short and long-term disability and more. We even offer pet insurance for your four-legged family members.
- Early access to earned wages with Daily Pay, tuition reimbursement to help further your career and adoption assistance to help you grow your family.
With a collective goal to champion a culture of belonging where everyone feels valued and respected, we honor the ways people are unique and embrace what brings us together.
And, we believe equipping you with support and development opportunities is a vital part of delivering an exceptional employment experience.
Find a fulfilling career and make a difference with UnityPoint Health.
Responsibilities:- Partner with nurses, providers, and clinical teams to improve workflows and processes.
- Serve as a clinical expert for electronic health records and other healthcare technology.
- Identify opportunities to improve patient safety, quality, efficiency, and the overall care experience.
- Support system implementations, upgrades, testing, troubleshooting, and optimization.
- Develop and provide education and training to clinical staff on technology and system changes.
- Analyze clinical data and system functionality to identify trends and recommend improvement
- Graduate of an accredited nursing program (must obtain BSN within 12 years of hire date)
Experience:
- (3) three years of prior experience using EPIC EMR
License/Certification:
- Current licensure in good standing to practice as a Registered Nurse in Iowa
See All 31 Clinical Registered Nurse Jobs in Iowa
Find roles in Iowa that match your experience and apply in just a few clicks.
Find JobsClinical Registered Nurse Jobs by City in Iowa
Where Iowa roles are concentrated, by current openings.
Clinical Registered Nurse Job Market in Iowa
A snapshot from current Iowa openings, updated as new roles post.
Who's Hiring
Top Industries Hiring
- Healthcare & Medical Services
What Iowa Employers Look For
The qualifications that appear most often in clinical registered nurse jobs across Iowa.
- Active Registered Nurse license issued or recognized by the Iowa Board of Nursing
- Associate or bachelor's degree in nursing from an accredited program
- Current BLS certification required before starting clinical orientation
- Minimum one year of acute care or clinical nursing experience preferred
- Proficiency with electronic health record systems such as Epic or Cerner
- Strong clinical assessment skills and ability to work rotating or weekend shifts
Clinical Registered Nurse Jobs in Iowa: Frequently Asked Questions
How do you become a clinical registered nurse in Iowa?
You become a clinical registered nurse in Iowa by completing an accredited associate or bachelor's degree nursing program, then passing the NCLEX-RN exam. Licensure is issued by the Iowa Board of Nursing, which also participates in the Nurse Licensure Compact, allowing nurses licensed in other compact states to practice in Iowa without obtaining a separate state license. Most Iowa hospital systems require at minimum an associate degree, though larger health systems increasingly prefer a BSN.
How much do clinical registered nurses make in Iowa?
Clinical registered nurses in Iowa earn a median of about $78,630 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $63,840 for the lowest 10% to over $100,500 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire clinical registered nurses in Iowa?
Companies currently hiring clinical registered nurses in Iowa include UnityPoint Health, HealthTrust Workforce Solutions, and MercyOne, per current listings on Migrate Mate as of August 2026. Iowa's largest hiring activity tends to be concentrated within integrated health systems that operate multiple hospital campuses and outpatient clinics throughout the state.
Which Iowa cities have the most clinical registered nurse jobs?
Dubuque, Ottumwa, and Des Moines have the most clinical registered nurse openings in Iowa. Des Moines leads due to the density of major health system headquarters and regional medical centers there, while Iowa City's volume is driven largely by University of Iowa Health Care, and Cedar Rapids draws from MercyOne and other community hospital networks anchored in the Corridor region.
Are there remote clinical registered nurse jobs in Iowa?
Yes, but they're rare. Clinical registered nurse work is fundamentally hands-on and patient-facing, so most positions require on-site presence. About 29% of clinical registered nurse openings tied to Iowa are remote or hybrid as of August 2026, and those roles are typically in telephonic triage, utilization review, or care management rather than direct bedside nursing.
How can I get hired as a clinical registered nurse in Iowa with little or no experience?
The most realistic entry path is applying to a nurse residency program, which major Iowa health systems like UnityPoint Health and University of Iowa Health Care run specifically for new graduates and nurses with under one year of acute care experience. These structured programs provide clinical mentorship and count toward your first year of documented experience. Candidates with a BSN, current BLS certification, and an active Iowa Board of Nursing license have the clearest path to acceptance into these programs.
Where can I find and apply to clinical registered nurse jobs in Iowa?
You can find and apply to clinical registered nurse jobs in Iowa on Migrate Mate, which lists current Iowa openings. Search for roles that fit your specialty and experience level, then apply directly to the ones that match.
See All 31 Clinical Registered Nurse Jobs in Iowa
Find roles in Iowa that match your experience and apply in just a few clicks.
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