Clinical Research Nurse Jobs in Illinois
Clinical Research Nurse jobs in Illinois are open across Chicago, Springfield, and Maywood and other Illinois metros, with employers like The University of Chicago, Advocate Aurora Health, and City of Hope hiring at every experience level. Find a role that fits below and apply directly.
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Department
BSD MED - Cardiology - Clinical Research Staff
About the Department
The Section of Cardiology was founded in 1950 and has a proud history. We are now charting a new course that will propel us to the forefront of cardiovascular medicine. The strength of the Section reflects the quality and dedication of its faculty, trainees, and support staff and is enhanced by the rich environment at the University of Chicago.
Our section prides itself on its strong and integrated programs in clinical care, research, and education. The strength of our clinical programs is essential not only to our ability to provide excellent patient care, but to our ability to perform research that advances the frontiers of clinical practice and to train future generations of physicians. Our research programs allow us to advance the scientific basis and clinical practice and to train researchers who can carry this scientific mission into the future.
Job Summary
The Clinical Research Nurse works in the Department of Medicine, Section of Cardiology, under the supervision of the Clinical Research Manager, and the Principal Investigator(s) (PI) of assigned studies. This position will play a central role in the conduct of investigator-initiated and industry-sponsored clinical trials across the cardiovascular service line, including (but not limited to) heart failure, interventional cardiology, electrophysiology, pulmonary hypertension, and device-based therapies. This role bridges clinical care and research operations, ensuring high-quality, ethical, and protocol-compliant study conduct while supporting patient-centered trial participation. These research trials (both established and future) will include multi-centered cooperative group and intergroup trials at a national level, multi-institutional pharmaceutical trials, device trials, and single and multi-centered trials, designed, implemented, and coordinated in the Section.
Responsibilities
- Ensure compliance with each study’s protocol by providing thorough review and documentation at each subject study visit.
- Participate in recruitment and selection of study participants by interviewing and documenting medical history to determine compliance with eligibility requirements.
- Perform medical tests, including, but not limited to, vital signs, imaging studies, and electrocardiograms.
- Administer investigational medications and perform patient assessments during clinic visits to determine presence of side effects; notify Principal Investigator of findings/issues.
- Provide patient education and medical information to study patients to ensure understanding of proper medication dosage, administration, and disease treatment.
- Document medical data in patient chart to capture protocol requirements.
- Provide accurate and timely data collection, documentation, entry, and appropriate reporting to sponsors and institutions.
- Serve as liaison between PI, sponsoring agent, regulatory groups, patient, family members, referring MD's/community MD's, pharmacist, statistician, and other members of the research team.
- Interprets information from caregivers, nurses, or physicians about patient condition, treatment plans, or appropriate activities.
- Has a solid understanding of the information and techniques needed to diagnose and treat human injuries, diseases, and deformities. This includes symptoms, treatment alternatives, drug properties and interactions, and preventive health-care measures.
- Performs other related work as needed.
Minimum Qualifications
Education:
Minimum requirements include a college or university degree in related field.
Work Experience:
Minimum requirements include knowledge and skills developed through 2-5 years of work experience in a related job discipline.
Certifications:
Preferred Qualifications
Education:
- Bachelor of Science Degree in Nursing.
Experience:
- Experience in nursing (ideally cardiology nursing), and demonstrated knowledge about home care, palliative care, advanced directives, pain management, symptom control, and/or discharge planning.
Preferred Competencies
- Fundamental working knowledge of clinical research.
- Knowledge of patient care fundamentals, including aseptic principles and techniques.
- Ability to provide direct patient care in a professional and respectful manner.
- Excellent verbal and written communication.
- Ability to read documents or instruments.
- Ability to perform multiple concurrent tasks with occasional interruptions.
- Ability to exercise discretion and confidentiality while handling sensitive situations.
- Ability to solve problems by applying math or reasoning principles.
- Ability to adapt to changing working situations and work assignments.
Application Documents
- Resume/CV (required)
- Cover Letter (required)
When applying, the document(s) MUST be uploaded via the My Experience page, in the section titled Application Documents of the application.
Job Family
Healthcare & Medical Services
Role Impact
Individual Contributor
Scheduled Weekly Hours
40
Drug Test Required
Yes
Health Screen Required
Yes
Motor Vehicle Record Inquiry Required
No
Pay Rate Type
Salary
FLSA Status
Exempt
Pay Range
$70,000.00 - $100,000.00
The included pay rate or range represents the University’s good faith estimate of the possible compensation offer for this role at the time of posting.
Benefits Eligible
Yes
The University of Chicago offers a wide range of benefits programs and resources for eligible employees, including health, retirement, and paid time off. Information about the benefit offerings can be found in the Benefits Guidebook.
Posting Statement
The University of Chicago is an equal opportunity employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender, gender identity, or expression, national or ethnic origin, shared ancestry, age, status as an individual with a disability, military or veteran status, genetic information, or other protected classes under the law. For additional information please see the University's Notice of Nondiscrimination.
Job seekers in need
See All 11 Clinical Research Nurse Jobs in Illinois
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Find Clinical Research Nurse JobsClinical Research Nurse Jobs by City in Illinois
Where Illinois roles are concentrated, by current openings.
Clinical Research Nurse Job Market in Illinois
A snapshot from current Illinois openings, updated as new roles post.
Who's Hiring
- The University of Chicago2

- Advocate Aurora Health1

- City of Hope1

- Loyola University Chicago1

- Memorial Health1

Top Industries Hiring
- Healthcare & Medical Services7
- Education5
What Illinois Employers Look For
The qualifications that appear most often in clinical research nurse jobs across Illinois.
- Active RN license in the state of employment
- Minimum two years of clinical nursing experience in a relevant specialty
- Working knowledge of ICH-GCP guidelines and Good Clinical Practice standards
- Experience with electronic data capture systems such as Medidata Rave or REDCap
- CCRP or CCRC certification preferred or required by many employers
- Ability to obtain and maintain site-specific training and protocol certifications
Clinical Research Nurse Jobs in Illinois: Frequently Asked Questions
How many clinical research nurse jobs are there in Illinois?
There are 11+ clinical research nurse openings in Illinois on Migrate Mate as of June 2026, with the most roles in Chicago, Springfield, and Maywood. New positions post regularly as employers across Illinois hire.
Which Illinois cities have the most clinical research nurse jobs?
Chicago, Springfield, and Maywood have the most clinical research nurse openings in Illinois right now, with additional roles spread across smaller metros statewide.
Which companies hire clinical research nurses in Illinois?
Employers hiring clinical research nurses in Illinois include The University of Chicago, Advocate Aurora Health, and City of Hope, based on current listings on Migrate Mate as of June 2026.
Are there remote clinical research nurse jobs in Illinois?
Yes. About 9% of clinical research nurse openings tied to Illinois are remote or hybrid as of June 2026. The rest are on-site roles based in Illinois metros.
How do I apply for clinical research nurse jobs in Illinois?
You can apply to clinical research nurse jobs in Illinois directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred Illinois location, then apply to each one that fits.
See All 11 Clinical Research Nurse Jobs in Illinois
Find roles in Illinois that match your experience and apply in just a few clicks.
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