Clinical Research Nurse Jobs in Texas
Clinical Research Nurse jobs in Texas are among the most active in the country, concentrated in academic medical centers, pharmaceutical research organizations, and large hospital-affiliated trial units, with openings at every level from entry-level coordinators through senior and principal investigator-support roles. Houston, Dallas, and San Antonio are the primary hiring hubs, anchored by institutions and organizations such as MD Anderson Cancer Center, UT Southwestern Medical Center, and ICON plc, all of which maintain substantial clinical trial operations in Texas. Oncology, cardiovascular research, and neurology trials represent the most consistent demand for clinical research nurses in the state. Find a role that fits below and apply directly.
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At Houston Methodist, the Clinical Research Nurse (CRN) for Neurology - Alzheimer position is licensed clinician who is responsible for, with minimal supervision, supporting, facilitating and coordinating the daily clinical trial activities and plays a critical role in the conduct of the study. This position functions at the Competent level according to the Benner's model of clinical practice. The CRN provides direct patient care effectively and efficiently to research patients under the supervision of the Clinical Trials Manager and Principal Investigator. This position implements clinical research patient care via the research protocol. The CRN position works with the Performance Improvement department, sponsor, and institution to support and provide guidance on the administration of the GCP compliance, financial and other related aspects of the research study. This position serves as a liaison between physicians, patients, staff and sponsors. The CRN position delivers exceptional patient care and adheres to standards and guidelines established by regulatory agencies and Houston Methodist to ensure optimal patient safety and customer service.
FLSA STATUS
Exempt
QUALIFICATIONS
Education
Bachelor’s degree in Nursing or higher from an accredited school of nursing
Experience
One year acute care or clinical research experience
LICENSES AND CERTIFICATIONS
Required
RN - Registered Nurse - Texas State Licensure - Texas Board of Nursing_PSV Compact Licensure – Must obtain permanent Texas license within 60 days (if establishing Texas residency) and
BLS - Basic Life Support or Instructor (AHA) - American Heart Association
SKILLS AND ABILITIES
Demonstrates the skills and competencies necessary to safely perform the assigned job, determined through ongoing skills, competency assessments, and performance evaluations
- Sufficient proficiency in speaking, reading, and writing the English language necessary to perform the essential functions of this job, especially with regard to activities impacting patient or employee safety or security
- Ability to effectively communicate with patients, physicians, family members and co-workers in a manner consistent with a customer service focus and application of positive language principles
- Demonstrates clinical problem solving and critical thinking using an analytical approach
- Adapts to multiple ongoing priorities with minimal supervision including, organizing work flow and actively participating in problem-solving
- Exhibits strong interpersonal and team player skills with all levels of the healthcare team and assures delivery of excellent customer service to all patients, visitors, physicians and co-workers
- Possesses basic computer knowledge; operates multiple computer systems to include, Hospital Information Systems and Office software to maintain patient and exam documents
ESSENTIAL FUNCTIONS
PEOPLE ESSENTIAL FUNCTIONS
Uses therapeutic communication, which includes active listening and teaching, to provide research interventions care to clinical research patients and coordinates with interprofessional team as written in the research protocol. Contributes to teamwork by consistently responding positively to requests for assistance.
- Provides patient education regarding disease process and involves patient and family in decision-making processes. Consistently evaluates the patient’s comprehension and adapts teaching methods accordingly. Advocates on patient/family’s behalf to identify and resolve clinical and ethical concerns, utilizing appropriate resources.
- Facilitates onboarding and orientation process for new staff in conjunction with Clinical Trials Manager. Precepts new clinical research staff in clinical setting. Uses peer-to-peer accountability towards improvement of department score for turnover/retention/employee engagement.
SERVICE ESSENTIAL FUNCTIONS
Demonstrates ability to manage multiple projects at different stages of the clinical research process (Phase 1-Phase 4).
- Coordinates pre-site and site initiation visits; trains hospital and clinic nurses/physicians on scientific aspects and protocol requirements of research studies. Attends off-site investigator meetings.
- Provides comprehensive nursing assessments to develop, coordinate, implement and evaluate activities associated with all phases of clinical research projects. Monitors safety of all research subjects and reports adverse events.
- Helps drive improvement of department score for patient satisfaction, through peer-to-peer accountability to service standards.
QUALITY/SAFETY ESSENTIAL FUNCTIONS
Follows the clinical research protocol and nursing process and modifies care based on continuous evaluation of the research patient’s condition. Performs nursing functions independently and in collaboration with Principal Investigator as approved by Hospital administration for the conduct of clinical research.
- Collects, processes and ships protocol-required lab specimens; maintains supply and equipment inventory; maintains appropriate laboratory certification as well as perform study closeout procedures including post-study documentation, return of study materials to the sponsor and data archiving.
- Collaborates and prepares with Principal Investigator, Institutional Review Board (IRB) and regulatory documents for submission assuring compliance with local and federal regulatory standards as appropriate and required by the research protocol. Follows International Council for Harmonisation/Good Clinical Practice guidelines.
FINANCE ESSENTIAL FUNCTIONS
Assisting financial analyst in development of calendar and Medicare Cost Analysis. standard of care procedures vs. research and approving study calendars for Clinical Trials Management System.
- Identifies, recruits, and consents clinical research subjects for participation in approved clinical trials; monitors enrollment goals and modifies enrollment strategies, as necessary.
- Enters study related data into Clinical Trials Management System (CTMS) in accordance with Houston Methodist Research Institute policy.
GROWTH/INNOVATION ESSENTIAL FUNCTIONS
Identifies and presents areas for innovation, efficiency and improvement in patient care operations using evidence-based practice literature. Offers innovative solutions through evidence-based practice/performance improvement projects and activities.
Maintains accountability for ongoing professional growth and development. Participates in unit activities. Completes and updates the individual development plan (IDP) on an ongoing basis.
SUPPLEMENTAL REQUIREMENTS
WORK ATTIRE
- Uniform: Yes
- Scrubs: Yes
- Business professional: No
- Other (department approved): No
ON-CALL
- Note that employees may be required to be on-call during emergencies (ie. Disaster, Severe Weather Events, etc) regardless of selection below.
- On Call No
TRAVEL
Travel specifications may vary by department
- May require travel within the Houston Metropolitan area No
- May require travel outside Houston Metropolitan area No
Company Profile:
Houston Methodist Academic Institute oversees the Education Institute and Research Institute. The Academic Institute aligns our research and education initiatives in service to the clinical mission, providing solutions that answer the call for new technologies and skills our clinicians need for patient care. Houston Methodist Education Institute coordinates our primary academic affiliation with Weill Cornell Medicine and other joint programs, including the Engineering Medicine Program at Texas A&M University Intercollegiate School of Engineering Medicine. The Education Institute also oversees continuing medical education and graduate medical education, and supports trainees in residence for medical, nursing, allied health and research education programs. Houston Methodist Research Institute supports research programs and infrastructure that enable faculty across the system to bring new scientific discoveries to patients as rapidly as possible through the full cycle of a cure from conceptual bench research, to prototyping and development, to clinical trials and FDA approval. The Research Institute supports clinical research protocols and extramurally funded translational research programs.
Houston Methodist is an Equal Opportunity Employer.
At Houston Methodist, the Clinical Research Nurse (CRN) for Neurology - Alzheimer position is licensed clinician who is responsible for, with minimal supervision, supporting, facilitating and coordinating the daily clinical trial activities and plays a critical role in the conduct of the study. This position functions at the Competent level according to the Benner's model of clinical practice. The CRN provides direct patient care effectively and efficiently to research patients under the supervision of the Clinical Trials Manager and Principal Investigator. This position implements clinical research patient care via the research protocol. The CRN position works with the Performance Improvement department, sponsor, and institution to support and provide guidance on the administration of the GCP compliance, financial and other related aspects of the research study. This position serves as a liaison between physicians, patients, staff and sponsors. The CRN position delivers exceptional patient care and adheres to standards and guidelines established by regulatory agencies and Houston Methodist to ensure optimal patient safety and customer service.
FLSA STATUS
Exempt
QUALIFICATIONS
Education
Bachelor’s degree in Nursing or higher from an accredited school of nursing
Experience
One year acute care or clinical research experience
LICENSES AND CERTIFICATIONS
Required
RN - Registered Nurse - Texas State Licensure - Texas Board of Nursing_PSV Compact Licensure – Must obtain permanent Texas license within 60 days (if establishing Texas residency) and
BLS - Basic Life Support or Instructor (AHA) - American Heart Association
SKILLS AND ABILITIES
Demonstrates the skills and competencies necessary to safely perform the assigned job, determined through ongoing skills, competency assessments, and performance evaluations
- Sufficient proficiency in speaking, reading, and writing the English language necessary to perform the essential functions of this job, especially with regard to activities impacting patient or employee safety or security
- Ability to effectively communicate with patients, physicians, family members and co-workers in a manner consistent with a customer service focus and application of positive language principles
- Demonstrates clinical problem solving and critical thinking using an analytical approach
- Adapts to multiple ongoing priorities with minimal supervision including, organizing work flow and actively participating in problem-solving
- Exhibits strong interpersonal and team player skills with all levels of the healthcare team and assures delivery of excellent customer service to all patients, visitors, physicians and co-workers
- Possesses basic computer knowledge; operates multiple computer systems to include, Hospital Information Systems and Office software to maintain patient and exam documents
ESSENTIAL FUNCTIONS
PEOPLE ESSENTIAL FUNCTIONS
Uses therapeutic communication, which includes active listening and teaching, to provide research interventions care to clinical research patients and coordinates with interprofessional team as written in the research protocol. Contributes to teamwork by consistently responding positively to requests for assistance.
- Provides patient education regarding disease process and involves patient and family in decision-making processes. Consistently evaluates the patient’s comprehension and adapts teaching methods accordingly. Advocates on patient/family’s behalf to identify and resolve clinical and ethical concerns, utilizing appropriate resources.
- Facilitates onboarding and orientation process for new staff in conjunction with Clinical Trials Manager. Precepts new clinical research staff in clinical setting. Uses peer-to-peer accountability towards improvement of department score for turnover/retention/employee engagement.
SERVICE ESSENTIAL FUNCTIONS
Demonstrates ability to manage multiple projects at different stages of the clinical research process (Phase 1-Phase 4).
- Coordinates pre-site and site initiation visits; trains hospital and clinic nurses/physicians on scientific aspects and protocol requirements of research studies. Attends off-site investigator meetings.
- Provides comprehensive nursing assessments to develop, coordinate, implement and evaluate activities associated with all phases of clinical research projects. Monitors safety of all research subjects and reports adverse events.
- Helps drive improvement of department score for patient satisfaction, through peer-to-peer accountability to service standards.
QUALITY/SAFETY ESSENTIAL FUNCTIONS
Follows the clinical research protocol and nursing process and modifies care based on continuous evaluation of the research patient’s condition. Performs nursing functions independently and in collaboration with Principal Investigator as approved by Hospital administration for the conduct of clinical research.
- Collects, processes and ships protocol-required lab specimens; maintains supply and equipment inventory; maintains appropriate laboratory certification as well as perform study closeout procedures including post-study documentation, return of study materials to the sponsor and data archiving.
- Collaborates and prepares with Principal Investigator, Institutional Review Board (IRB) and regulatory documents for submission assuring compliance with local and federal regulatory standards as appropriate and required by the research protocol. Follows International Council for Harmonisation/Good Clinical Practice guidelines.
FINANCE ESSENTIAL FUNCTIONS
Assisting financial analyst in development of calendar and Medicare Cost Analysis. standard of care procedures vs. research and approving study calendars for Clinical Trials Management System.
- Identifies, recruits, and consents clinical research subjects for participation in approved clinical trials; monitors enrollment goals and modifies enrollment strategies, as necessary.
- Enters study related data into Clinical Trials Management System (CTMS) in accordance with Houston Methodist Research Institute policy.
GROWTH/INNOVATION ESSENTIAL FUNCTIONS
Identifies and presents areas for innovation, efficiency and improvement in patient care operations using evidence-based practice literature. Offers innovative solutions through evidence-based practice/performance improvement projects and activities.
Maintains accountability for ongoing professional growth and development. Participates in unit activities. Completes and updates the individual development plan (IDP) on an ongoing basis.
SUPPLEMENTAL REQUIREMENTS
WORK ATTIRE
- Uniform: Yes
- Scrubs: Yes
- Business professional: No
- Other (department approved): No
ON-CALL
- Note that employees may be required to be on-call during emergencies (ie. Disaster, Severe Weather Events, etc) regardless of selection below.
- On Call No
TRAVEL
Travel specifications may vary by department
- May require travel within the Houston Metropolitan area No
- May require travel outside Houston Metropolitan area No
Company Profile:
Houston Methodist Academic Institute oversees the Education Institute and Research Institute. The Academic Institute aligns our research and education initiatives in service to the clinical mission, providing solutions that answer the call for new technologies and skills our clinicians need for patient care. Houston Methodist Education Institute coordinates our primary academic affiliation with Weill Cornell Medicine and other joint programs, including the Engineering Medicine Program at Texas A&M University Intercollegiate School of Engineering Medicine. The Education Institute also oversees continuing medical education and graduate medical education, and supports trainees in residence for medical, nursing, allied health and research education programs. Houston Methodist Research Institute supports research programs and infrastructure that enable faculty across the system to bring new scientific discoveries to patients as rapidly as possible through the full cycle of a cure from conceptual bench research, to prototyping and development, to clinical trials and FDA approval. The Research Institute supports clinical research protocols and extramurally funded translational research programs.
Houston Methodist is an Equal Opportunity Employer.
See All 18 Clinical Research Nurse Jobs in Texas
Find roles in Texas that match your experience and apply in just a few clicks.
Find Clinical Research Nurse JobsClinical Research Nurse Jobs by City in Texas
Where Texas roles are concentrated, by current openings.
Clinical Research Nurse Job Market in Texas
A snapshot from current Texas openings, updated as new roles post.
Who's Hiring
- Houston Methodist6
- Baylor Scott & White Health4
- MD Anderson Cancer Center2
- Cook Incorporated1
- Ethos Veterinary Health1
Top Industries Hiring
- Healthcare & Medical Services12
- Education5
- Biotechnology & Pharmaceuticals1
- Science & Research1
What Texas Employers Look For
The qualifications that appear most often in clinical research nurse jobs across Texas.
- Active Registered Nurse license issued or recognized by the Texas Board of Nursing
- Minimum two years of clinical nursing experience in a hospital or research setting
- Experience with GCP guidelines and human subjects research protocols
- CCRP or CCRC certification from the Society of Clinical Research Associates preferred
- Proficiency in electronic data capture systems such as Medidata Rave or REDCap
- Strong working knowledge of FDA regulations governing clinical trial conduct
Clinical Research Nurse Jobs in Texas: Frequently Asked Questions
How do you become a clinical research nurse in Texas?
You need an active Registered Nurse license from the Texas Board of Nursing, which requires completing an accredited nursing program and passing the NCLEX-RN exam. From there, most Texas employers expect at least one to two years of bedside or clinical experience before moving into research. Pursuing certification through the Society of Clinical Research Associates, such as the CCRP credential, strengthens your application and is often required by major research institutions and contract research organizations in Texas.
Which companies hire clinical research nurses in Texas?
Employers hiring clinical research nurses in Texas right now include Houston Methodist, Baylor Scott & White Health, and MD Anderson Cancer Center, based on current listings on Migrate Mate as of June 2026. Texas's deep concentration of academic medical systems, contract research organizations, and pharmaceutical trial sites means consistent hiring activity throughout the year, particularly in the Houston and Dallas metro areas.
Which Texas cities have the most clinical research nurse jobs?
Houston, Dallas, and Austin have the most clinical research nurse openings in Texas. Houston leads because of its exceptional density of cancer, cardiovascular, and rare disease trial activity anchored by institutions like MD Anderson and Texas Medical Center affiliates, while Dallas benefits from UT Southwestern and a large network of CRO offices, and San Antonio draws from its military medicine research infrastructure and UTHSCSA-affiliated programs.
Are there remote clinical research nurse jobs in Texas?
Yes, but they're rare. Clinical research nursing is largely hands-on, requiring direct patient contact, specimen handling, and on-site protocol adherence, so most roles are facility-based. About 6% of clinical research nurse openings tied to Texas are remote or hybrid as of June 2026, and those positions tend to involve study coordination tasks such as data entry, regulatory document management, and participant follow-up calls rather than direct patient care.
How can I get hired as a clinical research nurse in Texas with little or no experience?
The most realistic entry path is applying for a clinical research coordinator or clinical trials nurse associate role at a large Texas academic medical center, where prior bedside nursing experience substitutes for direct research background. MD Anderson Cancer Center and UT Southwestern both run structured onboarding programs that train new research nurses in GCP and protocol adherence. Nurses transitioning from oncology, cardiology, or ICU units are frequently favored because those clinical backgrounds map directly to the most active trial areas in Texas.
Where can I find and apply to clinical research nurse jobs in Texas?
You can find and apply to clinical research nurse jobs in Texas on Migrate Mate, which lists current openings across the state. Find roles that match your experience and specialty and apply directly to the ones that fit.
See All 18 Clinical Research Nurse Jobs in Texas
Find roles in Texas that match your experience and apply in just a few clicks.
Find Clinical Research Nurse Jobs