Nurse Practitioner Or Physician Assistant Jobs in South Dakota
Nurse Practitioner Or Physician Assistant jobs in South Dakota concentrate heavily in primary care, rural health, and hospital-based medicine, with demand running from new graduates to experienced clinicians managing independent panels. The most active hiring is in Sioux Falls, Rapid City, and Aberdeen, where systems like Sanford Health, Monument Health, and Avera Health anchor the market with consistent openings year-round. Family medicine, urgent care, and surgical assistance are the specialties drawing the most consistent postings statewide. See the openings below and apply to the ones that match your experience.
Find JobsOverview
Showing 5 of 35+ Nurse Practitioner Or Physician Assistant jobs
Careers With Purpose
Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland.
Facility: Chamberlain Clinic
Location: Chamberlain, SD
Address: 300 S Byron Blvd, Chamberlain, SD 57325, USA
Shift: Varies
Job Schedule: Full time
Weekly Hours: 40.00
Department Details
Opportunity to work in a clinic and ED setting.
Ability to practice in diverse, comprehensive practice.
Great opportunity to grow as a provider.
Job Summary
The Family Medicine Nurse Practitioner provides advanced nursing care to patients of all ages, from infants to older adults. This role involves assessing, diagnosing, treating, and managing acute and chronic illnesses, promoting health and wellness, and working in collaboration with physicians and other healthcare providers.
- Conduct comprehensive physical exams and health assessments
- Obtain and interpret patient histories and diagnostic tests
- Diagnose and treat common acute and chronic medical conditions
- Prescribe medications and therapeutic treatments within the scope of practice
- Develop and implement individualized care plans
- Provide health education and counseling on disease prevention and healthy lifestyle choices
- Manage follow-up care and coordinate referrals to specialists when needed
- Perform minor procedures as appropriate (e.g., wound care, suturing)
- Document patient care accurately in the electronic health record system
- Participate in quality improvement and practice initiatives
- Collaborate effectively with physicians, nurses, and other healthcare team members
- Maintain current knowledge of evidence-based practice guidelines.
Qualifications
Master’s or Doctorate degree from an accredited Nurse Practitioner program.
If APRN was licensed prior to August 1, 1995, master's degree in nursing is preferred.
Experience in primary care or family medicine preferred.
Current licensure as a Registered Nurse and Nurse Practitioner in each state of practice.
Current Drug Enforcement Administration (DEA) permit to prescribe controlled substances in each state of practice.
State Controlled Substance License (if required by State).
National board certification as a Family (FNP-C) or (FNP-BC).
Obtains and subsequently maintains required specific competencies and certifications as outlined on privilege form.
Privileging documents and related credentialing requirements will supersede this job description in defining minimum qualifications, criteria, and scope of practice, if variation between documents exists.
Benefits
Sanford offers an attractive benefits package for qualifying full-time and part-time employees. Depending on eligibility, a variety of benefits include health insurance, dental insurance, vision insurance, life insurance, a 401(k) retirement plan, work/life balance benefits, and a generous time off package to maintain a healthy home-work balance. For more information about Total Rewards, visit https://sanfordcareers.com/benefits.
Sanford is an EEO/AA Employer M/F/Disability/Vet. If you are an individual with a disability and would like to request an accommodation for help with your online application, please call 1-877-673-0854 or send an email to talent@sanfordhealth.org.
Practice Details: APP will work in clinic and cover emergency department, providing primary care in the clinic, and emergency medicine care in the ED.
Sanford has a Drug Free Workplace Policy. An accepted offer will require a drug screen and pre-employment background screening as a condition of employment.
Req Number: R-0265536
Job Function: Advanced Practice Provider
Featured: No
Specialty: Family Medicine
Visas Accepted: N/A
Careers With Purpose
Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland.
Facility: Chamberlain Clinic
Location: Chamberlain, SD
Address: 300 S Byron Blvd, Chamberlain, SD 57325, USA
Shift: Varies
Job Schedule: Full time
Weekly Hours: 40.00
Department Details
Opportunity to work in a clinic and ED setting.
Ability to practice in diverse, comprehensive practice.
Great opportunity to grow as a provider.
Job Summary
The Family Medicine Nurse Practitioner provides advanced nursing care to patients of all ages, from infants to older adults. This role involves assessing, diagnosing, treating, and managing acute and chronic illnesses, promoting health and wellness, and working in collaboration with physicians and other healthcare providers.
- Conduct comprehensive physical exams and health assessments
- Obtain and interpret patient histories and diagnostic tests
- Diagnose and treat common acute and chronic medical conditions
- Prescribe medications and therapeutic treatments within the scope of practice
- Develop and implement individualized care plans
- Provide health education and counseling on disease prevention and healthy lifestyle choices
- Manage follow-up care and coordinate referrals to specialists when needed
- Perform minor procedures as appropriate (e.g., wound care, suturing)
- Document patient care accurately in the electronic health record system
- Participate in quality improvement and practice initiatives
- Collaborate effectively with physicians, nurses, and other healthcare team members
- Maintain current knowledge of evidence-based practice guidelines.
Qualifications
Master’s or Doctorate degree from an accredited Nurse Practitioner program.
If APRN was licensed prior to August 1, 1995, master's degree in nursing is preferred.
Experience in primary care or family medicine preferred.
Current licensure as a Registered Nurse and Nurse Practitioner in each state of practice.
Current Drug Enforcement Administration (DEA) permit to prescribe controlled substances in each state of practice.
State Controlled Substance License (if required by State).
National board certification as a Family (FNP-C) or (FNP-BC).
Obtains and subsequently maintains required specific competencies and certifications as outlined on privilege form.
Privileging documents and related credentialing requirements will supersede this job description in defining minimum qualifications, criteria, and scope of practice, if variation between documents exists.
Benefits
Sanford offers an attractive benefits package for qualifying full-time and part-time employees. Depending on eligibility, a variety of benefits include health insurance, dental insurance, vision insurance, life insurance, a 401(k) retirement plan, work/life balance benefits, and a generous time off package to maintain a healthy home-work balance. For more information about Total Rewards, visit https://sanfordcareers.com/benefits.
Sanford is an EEO/AA Employer M/F/Disability/Vet. If you are an individual with a disability and would like to request an accommodation for help with your online application, please call 1-877-673-0854 or send an email to talent@sanfordhealth.org.
Practice Details: APP will work in clinic and cover emergency department, providing primary care in the clinic, and emergency medicine care in the ED.
Sanford has a Drug Free Workplace Policy. An accepted offer will require a drug screen and pre-employment background screening as a condition of employment.
Req Number: R-0265536
Job Function: Advanced Practice Provider
Featured: No
Specialty: Family Medicine
Visas Accepted: N/A
See All 35 Nurse Practitioner Or Physician Assistant Jobs in South Dakota
Find roles in South Dakota that match your experience and apply in just a few clicks.
Find JobsNurse Practitioner Or Physician Assistant Jobs by City in South Dakota
Where South Dakota roles are concentrated, by current openings.
Nurse Practitioner Or Physician Assistant Job Market in South Dakota
A snapshot from current South Dakota openings, updated as new roles post.
Who's Hiring
- Sanford Health18
- Avera Health5
- Sioux Center Health4
- Huron Regional Medical Center2
- Lyra Health1
Top Industries Hiring
- Healthcare & Medical Services
- Non-Profit & Social Services
What South Dakota Employers Look For
The qualifications that appear most often in nurse practitioner or physician assistant jobs across South Dakota.
- Active South Dakota nurse practitioner or physician assistant license issued by the South Dakota Board of Medical Examiners
- Master of Science in Nursing, Doctor of Nursing Practice, or accredited physician assistant master's degree required
- National certification from AANP, ANCC, or NCCPA required prior to start date
- Current DEA registration or eligibility to obtain South Dakota controlled substance prescribing authority
- Two or more years of clinical experience in a primary care, urgent care, or specialty setting preferred
- BLS and ACLS certification required, with ATLS preferred for surgical and emergency positions
Nurse Practitioner Or Physician Assistant Jobs in South Dakota: Frequently Asked Questions
How do you become a nurse practitioner or physician assistant in South Dakota?
Both roles require state licensure through the South Dakota Board of Medical Examiners. Nurse practitioners must hold an accredited graduate-level nursing degree and a national certification such as the AANP or ANCC credential before applying for licensure. Physician assistants must graduate from an accredited PA program and pass the PANCE exam. South Dakota participates in the Nurse Licensure Compact, so RNs with a multistate license may hold NP licensure here once the graduate credential is met.
Which companies hire nurse practitioner or physician assistants in South Dakota?
Companies currently hiring nurse practitioner or physician assistants in South Dakota include Sanford Health, Avera Health, and Sioux Center Health, per current listings on Migrate Mate as of July 2026. Sanford Health, Avera Health, and Monument Health are the dominant long-term employers in the state, operating clinics and hospital campuses across Sioux Falls, Rapid City, and smaller rural communities where advanced practice providers often serve as the primary point of care.
Which South Dakota cities have the most nurse practitioner or physician assistant jobs?
The cities with the most nurse practitioner or physician assistant openings in South Dakota are Sioux Falls, Aberdeen, and Rapid City. Sioux Falls drives the largest share of postings as the state's most populous city and home to both Sanford Health and Avera Health's flagship campuses, while Rapid City's volume reflects Monument Health's regional hospital and clinic network serving the western half of the state.
Are there remote nurse practitioner or physician assistant jobs in South Dakota?
Yes, but they're rare. Nurse practitioner and physician assistant roles are inherently hands-on and typically require an in-person patient relationship, which limits remote options significantly. About 14% of nurse practitioner or physician assistant openings tied to South Dakota are remote or hybrid as of July 2026, and those positions tend to be in telehealth primary care, chronic disease management, or utilization review rather than procedural or acute care specialties.
How can I get hired as a nurse practitioner or physician assistant in South Dakota with little or no experience?
The most realistic entry path is a new-graduate or transition-to-practice residency program, and both Sanford Health and Avera Health run structured advanced practice provider onboarding tracks designed for clinicians completing their first year post-licensure. Candidates who hold a South Dakota or compact license and are already certified should apply to family medicine and urgent care openings first, as those settings offer the broadest supervision support. Highlighting clinical rotations completed at South Dakota sites and rural health experience strengthens any application significantly.
Where can I find and apply to nurse practitioner or physician assistant jobs in South Dakota?
You can find and apply to nurse practitioner or physician assistant jobs in South Dakota on Migrate Mate, which lists current openings tied to South Dakota employers and locations. Search the listings to find roles that match your specialty, experience level, and preferred location, then apply directly to the positions that fit. No signup is required to see the openings.
See All 35 Nurse Practitioner Or Physician Assistant Jobs in South Dakota
Find roles in South Dakota that match your experience and apply in just a few clicks.
Find Jobs