Nurse Practitioner Or Physician Assistant Jobs in South Dakota

Nurse Practitioner Or Physician Assistant jobs in South Dakota concentrate heavily in primary care, rural health, and hospital-based medicine, with demand running from new graduates to experienced clinicians managing independent panels. The most active hiring is in Sioux Falls, Rapid City, and Aberdeen, where systems like Sanford Health, Monument Health, and Avera Health anchor the market with consistent openings year-round. Family medicine, urgent care, and surgical assistance are the specialties drawing the most consistent postings statewide. See the openings below and apply to the ones that match your experience.

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Overview

Open roles31
Top employerSanford Health
Top citySioux Falls, SD
Cities hiring14
Work type33% Remote
Top industryHealthcare

Showing 5 of 31+ Nurse Practitioner Or Physician Assistant jobs

APP - Nurse Practitioner or Physician Assistant | Plastic Surgery
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New 16h ago
APP - Nurse Practitioner or Physician Assistant | Plastic Surgery
Sanford Health
Rapid City, South Dakota
Caregiving & Elderly Support
Healthcare Administration
Patient Services & Wellbeing
Doctoral degree
10,000+

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APP - Nurse Practitioner or Physician Assistant | Interventional Radiology
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Added 4d ago
APP - Nurse Practitioner or Physician Assistant | Interventional Radiology
Sanford Health
Sioux Falls, South Dakota
Allied Health
Healthcare Administration
Nursing
10,000+

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Nurse Practitioner or Physician Assistant
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Added 4d ago
Nurse Practitioner or Physician Assistant
Horizon Health
Wessington Springs, South Dakota
Caregiving & Elderly Support
Healthcare Administration
Patient Services & Wellbeing
ATLS Certification
1,001-5,000

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Nurse Practitioner or Physician Assistant | Acute Care
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Added 1w ago
Nurse Practitioner or Physician Assistant | Acute Care
Avera Health
Brookings, South Dakota
Allied Health
Clinical Support
Healthcare Administration
10,000+

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Nurse Practitioner (NP) or Physician (MD/DO) – Part-Time
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Nurse Practitioner (NP) or Physician (MD/DO) – Part-Time
The Preservation Firm LLC
Nemo, South Dakota
Healthcare Administration
Nursing
Patient Services & Wellbeing
$69k - $96k/yr
On-Site
CPR Certification

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See All 31 Nurse Practitioner Or Physician Assistant Jobs in South Dakota

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Nurse Practitioner Or Physician Assistant Jobs by City in South Dakota

Where South Dakota roles are concentrated, by current openings.

Sioux Falls
11 jobs
Rapid City
4 jobs
Aberdeen
3 jobs
Mission
2 jobs
Nemo
1 job
Pierre
1 job
Gregory
1 job
Yankton
1 job
Brookings
1 job

Nurse Practitioner Or Physician Assistant Job Market in South Dakota

A snapshot from current South Dakota openings, updated as new roles post.

Who's Hiring

  • Sanford Health15
  • Avera Health8
  • Horizon Health2
  • Lyra Health1
  • Signify Health1

Top Industries Hiring

  • Healthcare & Medical Services

What South Dakota Employers Look For

The qualifications that appear most often in nurse practitioner or physician assistant jobs across South Dakota.

  • Active South Dakota nurse practitioner or physician assistant license issued by the South Dakota Board of Medical Examiners
  • Master of Science in Nursing, Doctor of Nursing Practice, or accredited physician assistant master's degree required
  • National certification from AANP, ANCC, or NCCPA required prior to start date
  • Current DEA registration or eligibility to obtain South Dakota controlled substance prescribing authority
  • Two or more years of clinical experience in a primary care, urgent care, or specialty setting preferred
  • BLS and ACLS certification required, with ATLS preferred for surgical and emergency positions

Nurse Practitioner Or Physician Assistant Jobs in South Dakota: Frequently Asked Questions

How do you become a nurse practitioner or physician assistant in South Dakota?

Both roles require state licensure through the South Dakota Board of Medical Examiners. Nurse practitioners must hold an accredited graduate-level nursing degree and a national certification such as the AANP or ANCC credential before applying for licensure. Physician assistants must graduate from an accredited PA program and pass the PANCE exam. South Dakota participates in the Nurse Licensure Compact, so RNs with a multistate license may hold NP licensure here once the graduate credential is met.

Which companies hire nurse practitioner or physician assistants in South Dakota?

Companies currently hiring nurse practitioner or physician assistants in South Dakota include Sanford Health, Avera Health, and Horizon Health, per current listings on Migrate Mate as of October 2026. Sanford Health, Avera Health, and Monument Health are the dominant long-term employers in the state, operating clinics and hospital campuses across Sioux Falls, Rapid City, and smaller rural communities where advanced practice providers often serve as the primary point of care.

Which South Dakota cities have the most nurse practitioner or physician assistant jobs?

The cities with the most nurse practitioner or physician assistant openings in South Dakota are Sioux Falls, Rapid City, and Aberdeen. Sioux Falls drives the largest share of postings as the state's most populous city and home to both Sanford Health and Avera Health's flagship campuses, while Rapid City's volume reflects Monument Health's regional hospital and clinic network serving the western half of the state.

Are there remote nurse practitioner or physician assistant jobs in South Dakota?

Yes, but they're rare. Nurse practitioner and physician assistant roles are inherently hands-on and typically require an in-person patient relationship, which limits remote options significantly. About 67% of nurse practitioner or physician assistant openings tied to South Dakota are remote or hybrid as of October 2026, and those positions tend to be in telehealth primary care, chronic disease management, or utilization review rather than procedural or acute care specialties.

How can I get hired as a nurse practitioner or physician assistant in South Dakota with little or no experience?

The most realistic entry path is a new-graduate or transition-to-practice residency program, and both Sanford Health and Avera Health run structured advanced practice provider onboarding tracks designed for clinicians completing their first year post-licensure. Candidates who hold a South Dakota or compact license and are already certified should apply to family medicine and urgent care openings first, as those settings offer the broadest supervision support. Highlighting clinical rotations completed at South Dakota sites and rural health experience strengthens any application significantly.

Where can I find and apply to nurse practitioner or physician assistant jobs in South Dakota?

You can find and apply to nurse practitioner or physician assistant jobs in South Dakota on Migrate Mate, which lists current openings tied to South Dakota employers and locations. Search the listings to find roles that match your specialty, experience level, and preferred location, then apply directly to the positions that fit. No signup is required to see the openings.

See All 31 Nurse Practitioner Or Physician Assistant Jobs in South Dakota

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