Oncology Registered Nurse Jobs in Missouri
Oncology Registered Nurse jobs in Missouri are among the most consistently in-demand nursing roles in the state, concentrated in academic medical centers, comprehensive cancer programs, and large hospital systems across St. Louis, Kansas City, and Springfield. Major employers with a lasting presence include BJC HealthCare, University of Missouri Health Care, and Saint Luke's Health System. The most sought-after specialties are infusion nursing, bone marrow transplant, and radiation oncology support. Find a role that fits below and apply directly.
Find JobsOverview
Showing 5 of 42+ Oncology Registered Nurse jobs











- Saint Louis, Missouri
- Nursing
- Nursing
- Regular
- Full-time
- Mercy Hospital South
- JR274032
Job Description
Find your calling at Mercy!
Utilizes the nursing process to provide patient care. Maintains professional accountability for provision of patient care for the assigned patients. Evaluates the overall effectiveness of care provided by other direct caregivers. Coordinates the patient care in conjunction with other departments. Maintains patient rights and confidentiality of patient information. Performs duties and responsibilities in a manner consistent with our mission, values, and Mercy Service Standards.Position Details:
Registered Nurse (RN) - Oncology Infusion Center - Mercy South
Location: David M. Sindelar Cancer Center - 10050 Kennerly Rd, St. Louis, MO 63128
Full -Time | 36 Hours/Week | Mon-Fri | Day Shift | 8:00am-4:30pm
What You'll Do
As an Infusion RN, you will:
- Assess patients before, during, and after infusion treatments
- Administer chemotherapy, immunotherapy, blood products, hydration therapy, and other infusion medications
- Monitor patients closely for treatment responses and adverse reactions
- Access and maintain peripheral IVs, ports, and central lines
- Collaborate with oncologists, advanced practice providers, pharmacists, and support staff to coordinate treatment plans
- Educate patients and families on medications, side effects, symptom management, and ongoing care needs
- Review laboratory results and communicate significant findings to the care team
- Document assessments, treatments, and patient responses in the electronic health record
- Maintain oncology treatment safety standards and infection prevention practices
- Provide compassionate support to patients and families throughout the treatment process
Qualifications
Education
- Graduate of an accredited school of nursing
Licensure
- Current, valid RN license
Certification
- CPR certification or ability to obtain within 90 days of employment
Experience
- Previous experience is not required
What Will Help You Succeed
- Strong clinical assessment and critical thinking skills
- Exceptional patient education and communication abilities
- Compassionate, patient-centered approach to care
- Ability to build meaningful relationships with patients and families
- Strong attention to detail and commitment to patient safety
- Ability to work collaboratively within a multidisciplinary oncology team
- Excellent organizational and time-management skills
- Desire to learn and grow within infusion and oncology nursing
Why Join Mercy's Infusion Cancer Center?
Our outpatient infusion center is designed to create a comfortable and healing environment for both patients and caregivers. Patients can choose from multiple treatment spaces, including a community treatment area, an open infusion room with natural views, a fireplace and virtual aquarium, or private treatment rooms. Amenities such as televisions, internet access, warm blankets, pillows, meals, and snacks help create a positive treatment experience.
As a member of our team, you'll have the opportunity to provide specialized nursing care while developing meaningful relationships with patients who return throughout their treatment journey. You'll be supported by an experienced oncology team dedicated to delivering exceptional care and improving the lives of those we serve.
Bring your compassion, clinical expertise, and passion for patient care to the David M. Sindelar Cancer Center. Apply today to join our Infusion Cancer Center team at Mercy South.
Why Mercy?
From day one, Mercy offers outstanding benefits - including medical, dental, and vision coverage, paid time off, tuition support, and matched retirement plans for team members working 32+ hours per pay period.
Join a caring, collaborative team where your voice matters. At Mercy, you'll help shape the future of healthcare through innovation, technology, and compassion. As we grow, you'll grow with us.
See All 42 Oncology Registered Nurse Jobs in Missouri
Find roles in Missouri that match your experience and apply in just a few clicks.
Find JobsOncology Registered Nurse Jobs by City in Missouri
Where Missouri roles are concentrated, by current openings.
Oncology Registered Nurse Job Market in Missouri
A snapshot from current Missouri openings, updated as new roles post.
Who's Hiring
- Mercy12

- Mosaic Life Care4

- American Traveler4

- Washington University in St. Louis4

- SSM Health3

Top Industries Hiring
- Healthcare & Medical Services
What Missouri Employers Look For
The qualifications that appear most often in oncology registered nurse jobs across Missouri.
- Active registered nurse license issued or recognized by the Missouri State Board of Nursing
- Associate or bachelor's degree in nursing from an accredited program
- Current BLS and ONS chemotherapy and biotherapy administration certification
- Minimum one to two years of oncology or medical-surgical acute care experience
- Familiarity with electronic health records systems such as Epic or Cerner
- Strong knowledge of symptom management, cancer treatment protocols, and patient education
Oncology Registered Nurse Jobs in Missouri: Frequently Asked Questions
How do you become a oncology registered nurse in Missouri?
You become an oncology registered nurse in Missouri by first completing an accredited associate or bachelor's degree in nursing, then passing the NCLEX-RN exam and applying for licensure through the Missouri State Board of Nursing. Missouri participates in the Nurse Licensure Compact, so nurses licensed in other compact states may practice without a separate Missouri license. Most employers then require or encourage the Oncology Certified Nurse credential, earned through the Oncology Nursing Certification Corporation after gaining clinical oncology experience.
How much do oncology registered nurses make in Missouri?
Oncology registered nurses in Missouri earn a median of about $81,780 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $63,230 for the lowest 10% to over $104,390 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire oncology registered nurses in Missouri?
Employers hiring oncology registered nurses in Missouri right now include Mercy, Mosaic Life Care, and American Traveler, based on current listings on Migrate Mate as of October 2026. Missouri's large integrated health systems and NCI-designated cancer programs drive consistent demand for oncology nursing staff across inpatient, outpatient infusion, and ambulatory care settings.
Which Missouri cities have the most oncology registered nurse jobs?
The Missouri cities with the most oncology registered nurse openings are St. Louis, Rolla, and Creve Coeur. St. Louis leads because of its concentration of academic medical centers and the Siteman Cancer Center network, Kansas City follows with major systems including University of Kansas Health System on the state border and Saint Luke's anchoring the metro, and Springfield draws steady openings through Mercy and CoxHealth serving the broader Ozarks region.
Are there remote oncology registered nurse jobs in Missouri?
Yes, but they're rare. Oncology nursing is primarily a hands-on clinical role requiring direct patient contact for chemotherapy administration, assessment, and symptom management. About 50% of oncology registered nurse openings tied to Missouri are remote or hybrid as of October 2026, and those positions are typically limited to telephonic triage nursing, care coordination, or utilization review roles that don't require bedside duties.
How can I get hired as a oncology registered nurse in Missouri with little or no experience?
The most realistic entry path is applying to a new graduate nurse residency program at a large Missouri health system, as BJC HealthCare, University of Missouri Health Care, and Mercy all run structured residencies that place new RNs into oncology or medical-surgical units where oncology patients are commonly treated. Gaining experience in med-surg, critical care, or infusion nursing roles first is a common lateral move that opens oncology-specific positions. Completing the ONS chemotherapy certification early and volunteering for oncology patient assignments during residency gives candidates a meaningful edge.
Where can I find and apply to oncology registered nurse jobs in Missouri?
You can find and apply to oncology registered nurse jobs in Missouri on Migrate Mate, which lists current Missouri openings across health systems, cancer centers, and outpatient clinics. Find the roles that fit your experience and credentials and apply directly to the employer.
See All 42 Oncology Registered Nurse Jobs in Missouri
Find roles in Missouri that match your experience and apply in just a few clicks.
Find Jobs