Registered Nurse Med Surg Jobs in South Carolina

Registered Nurse Med Surg jobs in South Carolina are concentrated in Charleston, Columbia, and Greenville, where systems like MUSC Health, Prisma Health, and Bon Secours operate large acute-care facilities with consistent med-surg units. Demand runs from new-graduate nurses to experienced charge nurses, with the strongest openings in post-surgical care, orthopedics, and cardiac step-down. South Carolina's growing retiree population and expanding suburban hospital campuses keep this one of the more active hiring markets in the Southeast. Find a role that fits below and apply directly.

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Overview

Open roles63
Top employerPrisma Health
Top cityColumbia, SC
Cities hiring11
Work type100% On-site
Top industryHealthcare

Showing 5 of 63+ Registered Nurse Med Surg jobs

Patient Care Technician (PCT) - Med-Surg Unit - St. Francis Eastside
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Patient Care Technician (PCT) - Med-Surg Unit - St. Francis Eastside
Bon Secours
Greenville, South Carolina
Allied Health
Healthcare Administration
Mental & Behavioral Health
Social Work & Counseling
BLS Certification
10,000+

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Neuro Med Surg Registered Nurse
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Added 5d ago
Neuro Med Surg Registered Nurse
HCA Healthcare Trident Hospital
Charleston, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
1,001-5,000

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RN Manager Med Surg
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Added 1w ago
RN Manager Med Surg
Grand Strand Medical Center
Myrtle Beach, South Carolina
Clinical Support
Healthcare Administration
Human Resources
Nursing
1,001-5,000

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PRN Registered Nurse (RN) Med Surg Tele (Nights) - Cherokee Medical Center (Duplicate)
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Added 2w ago
PRN Registered Nurse (RN) Med Surg Tele (Nights) - Cherokee Medical Center (Duplicate)
Spartanburg Regional Healthcare System
Gaffney, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing

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Patient Care Technician (PCT) - Med Surg - Bon Secours St. Francis Hospital
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Patient Care Technician (PCT) - Med Surg - Bon Secours St. Francis Hospital
Roper St. Francis Healthcare
Charleston, South Carolina
Allied Health
Healthcare Administration
Mental & Behavioral Health
Social Work & Counseling
BLS Certification
1,001-5,000

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See All 63 Registered Nurse Med Surg Jobs in South Carolina

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Registered Nurse Med Surg Jobs by City in South Carolina

Where South Carolina roles are concentrated, by current openings.

Columbia
19 jobs
Charleston
14 jobs
Greenville
13 jobs
Cheraw
3 jobs
Gaffney
3 jobs
Manning
3 jobs
Fort Mill
2 jobs
Spartanburg
2 jobs
Myrtle Beach
2 jobs

Registered Nurse Med Surg Job Market in South Carolina

A snapshot from current South Carolina openings, updated as new roles post.

Who's Hiring

  • Prisma Health17
  • Bon Secours13
  • Roper St. Francis Healthcare8
  • HCA Healthcare Trident Hospital7
  • McLeod Health6

Top Industries Hiring

  • Healthcare & Medical Services
  • Consulting & Professional Services

What South Carolina Employers Look For

The qualifications that appear most often in registered nurse med surg jobs across South Carolina.

  • Active South Carolina RN license or multistate Compact license recognized in South Carolina
  • Associate or Bachelor of Science in Nursing degree from an accredited program
  • Current BLS certification required, ACLS preferred for higher-acuity assignments
  • Minimum one year of med-surg or acute-care clinical experience for most positions
  • Demonstrated ability to manage a patient load of four to six on a medical-surgical floor
  • Proficiency with electronic health record systems such as Epic or Meditech

Registered Nurse Med Surg Jobs in South Carolina: Frequently Asked Questions

How do you become a registered nurse med surg in South Carolina?

You must hold an active registered nurse license issued by the South Carolina Board of Nursing, which requires completing an accredited ADN or BSN program and passing the NCLEX-RN exam. After licensure, most South Carolina hospitals place new nurses in a med-surg unit as a starting assignment, and many systems offer structured new-graduate residency programs to build clinical confidence before independent patient assignment.

How much do registered nurse med surgs make in South Carolina?

Registered nurse med surgs in South Carolina earn a median of about $82,360 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $66,860 for the lowest 10% to over $106,520 for the top 10%. Pay rises with experience, specialty, and employer.

Which companies hire registered nurse med surgs in South Carolina?

South Carolina registered nurse med surg roles are posted by Prisma Health, Bon Secours, and Roper St. Francis Healthcare and others right now, based on current listings on Migrate Mate as of October 2026. South Carolina's largest health systems, including those anchored in the Midlands and Lowcountry regions, account for the majority of consistent med-surg postings across the state.

Which South Carolina cities have the most registered nurse med surg jobs?

Columbia, Charleston, and Greenville lead South Carolina for registered nurse med surg openings. Charleston's concentration of MUSC Health campuses and Roper St. Francis facilities drives volume in the Lowcountry, Columbia anchors hiring in the Midlands through Prisma Health and Lexington Medical Center, and Greenville's expanding Bon Secours system fuels demand in the Upstate.

Are there remote registered nurse med surg jobs in South Carolina?

Yes, but they're rare. Bedside med-surg nursing requires hands-on patient care, so fully remote roles are uncommon in this specialty. About 0% of registered nurse med surg openings tied to South Carolina are remote or hybrid as of October 2026, and those positions are typically in utilization review, case management, or telephonic triage rather than direct floor nursing.

How can I get hired as a registered nurse med surg in South Carolina with little or no experience?

The most realistic path is applying to a new-graduate nurse residency program, which Prisma Health, MUSC Health, and Bon Secours Mercy Health all run at their South Carolina facilities for nurses within their first year of licensure. Starting in a patient care technician or nursing assistant role at the same hospital is another common route, as internal candidates with floor familiarity are frequently prioritized when RN positions open on that unit.

Where can I find and apply to registered nurse med surg jobs in South Carolina?

You can find and apply to registered nurse med surg jobs in South Carolina on Migrate Mate, which lists current openings across the state. Search the available roles, identify the ones that fit your experience and preferred location, and apply directly to the positions that match.

See All 63 Registered Nurse Med Surg Jobs in South Carolina

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