Systems Engineer Jobs at Amgen with Visa Sponsorship
Systems Engineer jobs at Amgen support the infrastructure behind drug discovery, manufacturing platforms, and clinical data systems. The company has a consistent track record of sponsoring work visas for this function, covering both initial nonimmigrant visas and longer-term permanent residence pathways.
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Get Access To All JobsLocation: US - North Carolina - Holly Springs
JOB ID: R-248693
WORK LOCATION TYPE: On Site
DATE POSTED: Jul. 13, 2026
CATEGORY: Engineering
SALARY RANGE: -
Join Amgen’s Mission of Serving Patients
At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.
Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.
Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lie within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Be part of Amgen's newest and most advanced drug substance manufacturing plant. When completed, the Amgen FleX Batch facility will combine the latest in disposable technologies with traditional stainless-steel equipment to allow for maximum flexibility in operations. The FleX Batch facility will not only feature the best in-class drug substance manufacturing technologies with embedded industry 4.0 capabilities, but it will also integrate sustainability innovations to reduce carbon and waste, as part of Amgen's plan to be a carbon-neutral company by 2027.
Manufacturing Systems Engineer: Automation - Delta V
What you will do
Let’s do this. Let’s change the world. As a Manufacturing Systems Engineer, you will work with a group of automation engineers who are responsible for building and maintaining various automation systems and platforms that support the GMP Drug Substance Plant Operations.
In this vital role as a member of the Facilities & Engineering (F&E) Automation team you will work hand in hand with the capital project team to deliver robust process automation systems to operate the new plant.
Responsibilities:
- Develop and maintain the process control system on Emerson DeltaV distributed control system (DCS).
- Collaborate with key stakeholders and end-users to understand and synthesize key process requirements, and to develop solutions using Amgen standard automation platform for process automation systems.
- Provide clear documentation for delivered solutions and processes.
- Support QA partners in performing computerized systems validation in a GxP environment.
- Perform Data Integrity Assessments (DIA) in accordance with the current Amgen and industry standards.
- Support process automation systems to ensure design aligns with Amgen specifications, incorporates the latest technology, and meets safety requirements.
- Support vendor FAT to ensure that control strategy and software code meet Amgen requirements.
- Develop and maintain engineering and maintenance documentation, and associated procedures for delivered solutions and processes.
- Support commissioning and qualification efforts including Automation Installation Verification/Automation Check Out (IV/ACO) in a fast-paced environment.
- Own and drive to completion Change Controls, CAPAs, and Deviations.
- Support technical root cause analysis, incident investigations, and troubleshooting.
- Support functional area projects focused on improving process equipment, utilities, and facilities as well as large capital projects to integrate new drug substance manufacturing technologies into the facility.
- Drive continuous improvement for process automation systems to improve operational workflows, safety, reliability, efficiency, and sustainability.
- Support day-to-day operations including rotational on-call support.
- Prepare/review Standard Operating Procedures (SOP) and cGMP documents.
- Be constantly curious and feed your passion and interests in groundbreaking technology. Use your given time to look for new and innovative ways to do business differently, better, and more cost effectively.
What we expect from you
We are all different, yet we all use our unique contributions to serve patients. The automation professional we seek is an engineer with these qualifications.
Basic Qualifications
- High School Diploma / GED and 8 years of Engineering experience OR
- Associate’s Degree and 6 years of Engineering experience OR
- Bachelor’s Degree and 2 years of Engineering experience OR
- Master’s Degree
Preferred Qualifications
- Degree in Electrical Engineering, Computer Science, Chemical Engineering, Biotech Engineering, or related field.
- Direct knowledge of Automation System design, experience in process control engineering and troubleshooting with GMP biopharmaceutical production facility equipment/systems automation such as media, harvest, bioreactors, solution prep, single use mixing vessels, chromatography, TFFL/TFFX, viral filtration, viral inactivation, UF/DF, depth filtration, drug substance fill, CIP/SIP, clean utilities, and integrating various OEM automation software.
- Experience in programming, installation, and lifecycle management of automation and field instrumentation technologies.
- Experience in programming, design, installation and lifecycle management of manufacturing process controls, and automation and field instrumentation technologies.
- Experience with Emerson DeltaV DCS system and ability to perform advanced troubleshooting, and system integration using OPC, Foundation Fieldbus, and Profibus technologies.
- Ability to interpret and apply GAMPs and GMPs, and familiarity with documentation in a highly regulated environment with requirements such as 21 CFR Part 11, ASTM 2500, S88 and S95.
- Self-directed team player able to work cross-functionally.
- Strong technical writing and communication skills.
What you can expect from us
As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.
In addition to the base salary, Amgen offers a Total Rewards Plan based on eligibility that may include:
- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans and bi-annual company-wide shutdowns
- Flexible work models, including remote work arrangements, where possible
for a career that defies imagination
In our quest to serve patients above all else, Amgen is the first to imagine and the last to doubt. Join us.
Location: US - North Carolina - Holly Springs
JOB ID: R-248693
WORK LOCATION TYPE: On Site
DATE POSTED: Jul. 13, 2026
CATEGORY: Engineering
SALARY RANGE: -
Join Amgen’s Mission of Serving Patients
At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.
Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.
Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lie within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Be part of Amgen's newest and most advanced drug substance manufacturing plant. When completed, the Amgen FleX Batch facility will combine the latest in disposable technologies with traditional stainless-steel equipment to allow for maximum flexibility in operations. The FleX Batch facility will not only feature the best in-class drug substance manufacturing technologies with embedded industry 4.0 capabilities, but it will also integrate sustainability innovations to reduce carbon and waste, as part of Amgen's plan to be a carbon-neutral company by 2027.
Manufacturing Systems Engineer: Automation - Delta V
What you will do
Let’s do this. Let’s change the world. As a Manufacturing Systems Engineer, you will work with a group of automation engineers who are responsible for building and maintaining various automation systems and platforms that support the GMP Drug Substance Plant Operations.
In this vital role as a member of the Facilities & Engineering (F&E) Automation team you will work hand in hand with the capital project team to deliver robust process automation systems to operate the new plant.
Responsibilities:
- Develop and maintain the process control system on Emerson DeltaV distributed control system (DCS).
- Collaborate with key stakeholders and end-users to understand and synthesize key process requirements, and to develop solutions using Amgen standard automation platform for process automation systems.
- Provide clear documentation for delivered solutions and processes.
- Support QA partners in performing computerized systems validation in a GxP environment.
- Perform Data Integrity Assessments (DIA) in accordance with the current Amgen and industry standards.
- Support process automation systems to ensure design aligns with Amgen specifications, incorporates the latest technology, and meets safety requirements.
- Support vendor FAT to ensure that control strategy and software code meet Amgen requirements.
- Develop and maintain engineering and maintenance documentation, and associated procedures for delivered solutions and processes.
- Support commissioning and qualification efforts including Automation Installation Verification/Automation Check Out (IV/ACO) in a fast-paced environment.
- Own and drive to completion Change Controls, CAPAs, and Deviations.
- Support technical root cause analysis, incident investigations, and troubleshooting.
- Support functional area projects focused on improving process equipment, utilities, and facilities as well as large capital projects to integrate new drug substance manufacturing technologies into the facility.
- Drive continuous improvement for process automation systems to improve operational workflows, safety, reliability, efficiency, and sustainability.
- Support day-to-day operations including rotational on-call support.
- Prepare/review Standard Operating Procedures (SOP) and cGMP documents.
- Be constantly curious and feed your passion and interests in groundbreaking technology. Use your given time to look for new and innovative ways to do business differently, better, and more cost effectively.
What we expect from you
We are all different, yet we all use our unique contributions to serve patients. The automation professional we seek is an engineer with these qualifications.
Basic Qualifications
- High School Diploma / GED and 8 years of Engineering experience OR
- Associate’s Degree and 6 years of Engineering experience OR
- Bachelor’s Degree and 2 years of Engineering experience OR
- Master’s Degree
Preferred Qualifications
- Degree in Electrical Engineering, Computer Science, Chemical Engineering, Biotech Engineering, or related field.
- Direct knowledge of Automation System design, experience in process control engineering and troubleshooting with GMP biopharmaceutical production facility equipment/systems automation such as media, harvest, bioreactors, solution prep, single use mixing vessels, chromatography, TFFL/TFFX, viral filtration, viral inactivation, UF/DF, depth filtration, drug substance fill, CIP/SIP, clean utilities, and integrating various OEM automation software.
- Experience in programming, installation, and lifecycle management of automation and field instrumentation technologies.
- Experience in programming, design, installation and lifecycle management of manufacturing process controls, and automation and field instrumentation technologies.
- Experience with Emerson DeltaV DCS system and ability to perform advanced troubleshooting, and system integration using OPC, Foundation Fieldbus, and Profibus technologies.
- Ability to interpret and apply GAMPs and GMPs, and familiarity with documentation in a highly regulated environment with requirements such as 21 CFR Part 11, ASTM 2500, S88 and S95.
- Self-directed team player able to work cross-functionally.
- Strong technical writing and communication skills.
What you can expect from us
As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.
In addition to the base salary, Amgen offers a Total Rewards Plan based on eligibility that may include:
- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans and bi-annual company-wide shutdowns
- Flexible work models, including remote work arrangements, where possible
for a career that defies imagination
In our quest to serve patients above all else, Amgen is the first to imagine and the last to doubt. Join us.
See all Systems Engineer Jobs at Amgen
Sign up for free to unlock all listings, filter by visa type, and get alerts for new Systems Engineer Jobs at Amgen.
Get Access To All JobsTips for Finding Systems Engineer Jobs at Amgen
Align your background to GxP environments
Amgen's Systems Engineer roles often require familiarity with GxP-regulated infrastructure and validated systems. Frame your resume around experience with FDA-compliant environments, change control processes, or computer system validation before you apply.
Target Amgen's Biologics manufacturing sites directly
Systems Engineer openings at Amgen frequently concentrate around its biomanufacturing campuses in Thousand Oaks and Rhode Island. Filtering by location before applying puts you closer to the teams that hire this role most actively.
Search open roles on Migrate Mate first
Amgen posts Systems Engineer roles across multiple channels, and not all flag visa sponsorship explicitly. Use Migrate Mate to filter Amgen's open Systems Engineer positions by the visa types you hold so you only pursue roles confirmed for your situation.
Clarify your visa category before the offer stage
Amgen sponsors several visa types for this function, including H-1B, E-3, TN, and F-1 OPT. If you're on OPT, confirm your graduation date and STEM extension eligibility early so the recruiter can sequence USCIS filing deadlines correctly.
Prepare credentials that satisfy specialty occupation standards
USCIS requires that H-1B petitions demonstrate the role is a specialty occupation. For Systems Engineer positions at a biopharmaceutical company, gather documentation showing your degree directly aligns with the technical scope of the role, not just general engineering.
Understand how PERM shapes your green card timeline
Amgen sponsors EB-2 and EB-3 permanent residence for systems engineering staff. PERM labor certification, filed with DOL, typically precedes the I-140 immigrant petition by several months, so discuss green card pathway timing with your future employer during negotiation.
Frequently Asked Questions
Does Amgen sponsor H-1B visas for Systems Engineers?
Yes, Amgen sponsors H-1B visas for Systems Engineer roles. The company has an established immigration program that handles H-1B petitions, including cap-subject filings submitted during the annual USCIS lottery window in March. If you're already in H-1B status with another employer, Amgen can also file an H-1B transfer, which lets you start work as soon as USCIS receives the petition.
How do I apply for Systems Engineer jobs at Amgen?
Applications go through Amgen's careers portal at amgen.com/careers. Search by job function using terms like 'Systems Engineer,' 'IT Infrastructure,' or 'Validation Engineer' to surface relevant roles. Before applying, confirm the posting explicitly mentions visa sponsorship or use Migrate Mate to filter Amgen's open Systems Engineer positions by your specific visa type to avoid wasted applications.
Which visa types does Amgen commonly sponsor for Systems Engineer roles?
Amgen sponsors H-1B, E-3 visa, TN visa, J-1 visa, and F-1 OPT and CPT for Systems Engineer positions. Australian citizens can use the E-3 visa, which has no lottery and allows two-year renewable status. Canadian and Mexican nationals in qualifying engineering fields may use the TN visa. For longer-term paths, Amgen also supports EB-2 and EB-3 Green Card sponsorship through PERM labor certification filed with DOL.
What qualifications does Amgen expect for Systems Engineer roles?
Amgen's Systems Engineer roles in its Science and Research environment typically require a bachelor's degree in computer science, electrical engineering, or a related technical discipline. Experience with validated systems, infrastructure in regulated GxP environments, and enterprise platforms commonly used in biopharmaceutical settings strengthens your candidacy. Roles supporting manufacturing or clinical operations may also expect familiarity with FDA 21 CFR Part 11 compliance requirements.
How long does Amgen's visa sponsorship process take for Systems Engineers?
Timeline depends heavily on the visa type. An H-1B cap-subject filing requires clearing the March lottery and has an October 1 start date, meaning the process spans six to nine months from application to authorized work. E-3 and TN visas can often be obtained through consular processing in two to six weeks. PERM-based Green Card sponsorship, by contrast, typically takes two or more years from filing through I-140 approval.