Manufacturing Supervisor Jobs in Massachusetts
Manufacturing Supervisor jobs in Massachusetts are in strong demand, with active hiring concentrated in the state's advanced manufacturing, defense, medical device, and biotechnology sectors at levels from entry-level team lead through senior plant management. The busiest hiring markets are in the Greater Boston area, Worcester, and Springfield, where established manufacturers such as Raytheon Technologies, GE Aerospace, and Fresenius Medical Care maintain significant operations. The most sought-after specialties in Massachusetts listings are lean manufacturing, quality systems oversight, and production scheduling in regulated industries. Find a role that fits below and apply directly.
Find Manufacturing Supervisor JobsOverview
Showing 5 of 23+ Manufacturing Supervisor jobs
Job Description
Job Description
The Manufacturing Operations Supervisor is a critical first-line leadership role within Cell Manufacturing. This position is responsible for direct management of personnel executing GMP cell processing operations for adherent and suspension cell cultures. The candidate will have strong leadership skills, GMP expertise, and commitment to patients.
The Supervisor will work one of the following shifts:
Second Shift - Tuesday to Saturday, 2:30PM - 11PM
Second Shift - Sunday to Thursday, 2:30PM - 11PM
Key Duties and Responsibilities:
- Builds and develops an efficient team of 2-8 direct reports capable of consistently producing clinical cellular product or intermediates according to cGMP standards. Includes hiring, orienting, training and coaching of personnel.
- Ensures cGMP compliance through direct oversight and education of team members.
- Shares responsibility of scheduling of personnel in coordination with other Manufacturing leadership.
- Manages direct reports’ projects to achieve department and corporate goals, including managing timelines and leading group meetings.
- Leads, investigates, and collaborates with cross-functional stakeholders regarding quality systems, including quality events, deviations, CAPAs, change controls, and risk assessments.
- Creates, revises, and reviews controlled documents including Standard Operating Procedures (SOPs) and Batch Records for manufacturing.
- Receive and manage equipment alarms.
- Serves as a technical SME for the team, troubleshoots problems independently.
- Demonstrates the Vertex Phenotype behaviors: Lead by Example; Learn, Teach & Develop; Foster Exceptional Collaboration; Drive Breakthrough Results; and Promote Enterprise Thinking Other duties and projects as assign as required to meet departmental requirements.
Knowledge and Skills:
- Extensive GMP experience, including as a lead or trainer
- Minimum of 3 years of cell culture experience, ideally in both adherent and suspension cultures
- A minimum of 0-2 years direct supervisory experience
- Working knowledge of federal requirements for GMP manufacturing (21CFR 210,211) and Quality Systems (21CFR 820)
- Expertise in cell processing and culture technologies for clinical materials production required
- Experience with bioreactors for cell culture Excellent computer skills including Word, Excel, Project, Outlook, equipment interfaces and electronic quality systems
Environment:
- Works in a cleanroom and office setting
- Must be able to remain in a stationary position 50% during processing activities
- Frequently move about inside the cleanroom to accomplish process tasks Occasionally moves lab equipment and materials weighing up to 50 pounds.
At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.
Pay Range:
$0 - $0Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
Flex Designation:
On-Site DesignatedFlex Eligibility Status:
In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.
#LI-Onsite
Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com
Job Description
Job Description
The Manufacturing Operations Supervisor is a critical first-line leadership role within Cell Manufacturing. This position is responsible for direct management of personnel executing GMP cell processing operations for adherent and suspension cell cultures. The candidate will have strong leadership skills, GMP expertise, and commitment to patients.
The Supervisor will work one of the following shifts:
Second Shift - Tuesday to Saturday, 2:30PM - 11PM
Second Shift - Sunday to Thursday, 2:30PM - 11PM
Key Duties and Responsibilities:
- Builds and develops an efficient team of 2-8 direct reports capable of consistently producing clinical cellular product or intermediates according to cGMP standards. Includes hiring, orienting, training and coaching of personnel.
- Ensures cGMP compliance through direct oversight and education of team members.
- Shares responsibility of scheduling of personnel in coordination with other Manufacturing leadership.
- Manages direct reports’ projects to achieve department and corporate goals, including managing timelines and leading group meetings.
- Leads, investigates, and collaborates with cross-functional stakeholders regarding quality systems, including quality events, deviations, CAPAs, change controls, and risk assessments.
- Creates, revises, and reviews controlled documents including Standard Operating Procedures (SOPs) and Batch Records for manufacturing.
- Receive and manage equipment alarms.
- Serves as a technical SME for the team, troubleshoots problems independently.
- Demonstrates the Vertex Phenotype behaviors: Lead by Example; Learn, Teach & Develop; Foster Exceptional Collaboration; Drive Breakthrough Results; and Promote Enterprise Thinking Other duties and projects as assign as required to meet departmental requirements.
Knowledge and Skills:
- Extensive GMP experience, including as a lead or trainer
- Minimum of 3 years of cell culture experience, ideally in both adherent and suspension cultures
- A minimum of 0-2 years direct supervisory experience
- Working knowledge of federal requirements for GMP manufacturing (21CFR 210,211) and Quality Systems (21CFR 820)
- Expertise in cell processing and culture technologies for clinical materials production required
- Experience with bioreactors for cell culture Excellent computer skills including Word, Excel, Project, Outlook, equipment interfaces and electronic quality systems
Environment:
- Works in a cleanroom and office setting
- Must be able to remain in a stationary position 50% during processing activities
- Frequently move about inside the cleanroom to accomplish process tasks Occasionally moves lab equipment and materials weighing up to 50 pounds.
At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.
Pay Range:
$0 - $0Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
Flex Designation:
On-Site DesignatedFlex Eligibility Status:
In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.
#LI-Onsite
Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com
See All 23 Manufacturing Supervisor Jobs in Massachusetts
Find roles in Massachusetts that match your experience and apply in just a few clicks.
Find Manufacturing Supervisor JobsManufacturing Supervisor Jobs by City in Massachusetts
Where Massachusetts roles are concentrated, by current openings.
Manufacturing Supervisor Job Market in Massachusetts
A snapshot from current Massachusetts openings, updated as new roles post.
Who's Hiring
Top Industries Hiring
- Science & Research
- Biotechnology & Pharmaceuticals
What Massachusetts Employers Look For
The qualifications that appear most often in manufacturing supervisor jobs across Massachusetts.
- Bachelor's degree in engineering, operations management, or a related technical field preferred
- Three or more years of supervisory experience in a manufacturing or production environment
- Familiarity with lean manufacturing principles including 5S, Kaizen, and continuous improvement methods
- Experience working in FDA-regulated, ISO-certified, or defense-compliant manufacturing facilities
- Proficiency with manufacturing execution systems, ERP platforms, and production scheduling tools
- Strong understanding of OSHA workplace safety standards and Massachusetts employee safety regulations
Manufacturing Supervisor Jobs in Massachusetts: Frequently Asked Questions
How do you become a manufacturing supervisor in Massachusetts?
Most manufacturing supervisors in Massachusetts move into the role by combining a technical or operations degree with hands-on production floor experience. Massachusetts employers in regulated industries, including medical devices and defense, typically expect candidates to have direct experience with ISO or FDA quality systems before stepping into supervision. Earning credentials such as a Certified Manufacturing Technologist designation through SME or completing lean manufacturing coursework strengthens a candidacy significantly in this market.
How much do manufacturing supervisors make in Massachusetts?
Manufacturing supervisors in Massachusetts earn a median of about $79,920 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $52,530 for the lowest 10% to over $114,800 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire manufacturing supervisors in Massachusetts?
Employers hiring manufacturing supervisors in Massachusetts right now include Vertex Pharmaceuticals, AbbVie, and Busek, based on current listings on Migrate Mate as of September 2026. Massachusetts's concentration of defense contractors, medical device makers, and biotech manufacturers means that many of the largest and most consistent openings come from companies operating regulated, high-precision production environments.
Which Massachusetts cities have the most manufacturing supervisor jobs?
The cities with the most manufacturing supervisor openings in Massachusetts are Boston, Worcester, and Agawam. Greater Boston anchors demand through its dense cluster of life sciences and defense primes, while Worcester and Springfield serve as the state's traditional industrial hubs, with long-established precision manufacturing and aerospace supply chain operations that generate steady supervisory hiring.
Are there remote manufacturing supervisor jobs in Massachusetts?
Yes, but they're rare. Manufacturing supervisor roles are fundamentally hands-on positions tied to a physical production floor, which limits remote options significantly. About 0% of manufacturing supervisor openings tied to Massachusetts are remote or hybrid as of September 2026, and those tend to involve oversight or coordination functions in multi-site or administrative capacities rather than direct floor supervision.
How can I get hired as a manufacturing supervisor in Massachusetts with little or no experience?
The most realistic entry path is moving from a skilled production technician or team lead role into a supervisory position within the same facility. Large Massachusetts manufacturers in the medical device and defense sectors, including those in the Route 128 corridor and Worcester County, frequently promote from within or hire associate supervisors from adjacent roles such as quality inspector, shift coordinator, or production planner. Completing a certificate program in operations management or lean manufacturing at a Massachusetts community college adds a measurable credential that hiring managers in this market recognize.
Where can I find and apply to manufacturing supervisor jobs in Massachusetts?
You can find and apply to manufacturing supervisor jobs in Massachusetts on Migrate Mate, which lists current Massachusetts openings from employers actively hiring in the state. Find roles that fit your experience and location and apply directly to each one.
See All 23 Manufacturing Supervisor Jobs in Massachusetts
Find roles in Massachusetts that match your experience and apply in just a few clicks.
Find Manufacturing Supervisor Jobs