Operations Supervisor Jobs in North Carolina
Operations Supervisor jobs in North Carolina are in strong, consistent demand, with openings concentrated in manufacturing, logistics, and distribution across a state that serves as a major Southeast freight and production corridor. Charlotte, Raleigh-Durham, and Greensboro are the largest hiring metros, with established employers like Honeywell, Lowe's, and Duke Energy maintaining substantial operations supervisor workforces in the region. The most sought-after specialties include distribution center operations, production floor supervision, and supply chain coordination. Find a role that fits below and apply directly.
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Work Schedule
12 hr shift/nightsEnvironmental Conditions
Cleanroom: no hair products, jewelry, makeup, nail polish, perfume, exposed piercings, facial hair etc... allowedJob Description
As part of the Thermo Fisher Scientific team, you’ll discover meaningful work that makes a positive impact on a global scale. We provide our global teams with the resources needed to achieve individual career goals while helping to take science a step beyond by developing solutions for some of the world’s toughest challenges, like protecting the environment, making sure our food is safe or helping find cures for cancer.
As part of the Pharmaceutical Services Group (PSG), the Greenville, North Carolina Steriles site manufactures high-quality sterile pharmaceutical products in a fast-paced, regulated environment supporting customers from development through commercial production.
Excellent Benefits Package
Review our company’s Total Rewards
Medical, Dental, & Vision benefits-effective Day 1
Paid Time Off & Holidays
401K Company Match up to 5%
Tuition Reimbursement – eligible after 90 days!
Employee Referral Bonus
Employee Discount Program
Recognition Program
Charitable Gift Matching
Company Paid Parental Leave
Career Advancement Opportunities
Location/Division Specific Information
Greenville, NC
Hours: 6pm-7am (2-2-3 schedule) 15% shift differential
RELOCATION ASSISTANCE IS NOT PROVIDED
- Must be legally authorized to work in the United States WITHOUT SPONSORSHIP OF ANY KIND NOW OR IN THE FUTURE.
- Must be able to pass a comprehensive background check, which includes a drug screen.
We have industry-leading sterile injectable facilities providing solutions to take essential products from pre-clinical to the market. Pharmaceutical products come in many different dose forms including inhalations, oral dose, cream/ointment and injectables.
Discover Impactful Work:
The B52 Supervisor (Combi 1) provides frontline leadership for manufacturing and filling operations, ensuring safe, compliant, and efficient production of high-quality pharmaceutical products. In this role, you will lead production teams, drive continuous improvement initiatives, and support operational excellence while maintaining compliance with cGMP and regulatory requirements.
A Day in the Life:
- Lead and develop production teams while fostering accountability, engagement, and organizational change.
- Ensure production, quality, schedule, and cost objectives are achieved while addressing deviations.
- Maintain compliance with cGMPs, FDA, OSHA, and internal quality requirements.
- Plan, monitor, and adjust daily production schedules to meet customer commitments.
- Promote a strong safety culture and ensure adherence to safety procedures.
- Evaluate employee performance, coach team members, and complete performance reviews.
- Support technical issue resolution and successful transfer of new manufacturing processes.
- Develop and maintain production documentation, procedures, and work instructions.
- Drive continuous improvement and cost reduction initiatives.
- Monitor attendance, approve timecards, ensure required training completion, and perform other assigned duties.
Keys to Success:
Education
- Bachelor’s degree in Physical, Biological, Chemical, Production Science, or related field strongly preferred. Equivalent education and experience will be considered.
Experience
- 5+ years of manufacturing experience.
- Minimum 2 years of leadership experience.
- Sterile pharmaceutical manufacturing experience preferred.
Knowledge, Skills, Abilities
- Knowledge of aseptic processing and manufacturing operations.
- Ability to manage multiple priorities in a fast-paced environment.
- Strong organizational skills and attention to detail.
- Self-motivated, dependable, and results oriented.
- Excellent interpersonal, written, and verbal communication skills.
- Ability to lead technical teams, resolve complex problems, and motivate employees.
- Strong judgment, confidentiality, and time management skills.
Physical Requirements / Work Environment
- Requires standing, walking, stooping, kneeling, lifting up to 50 pounds, occasional pushing/pulling over 100 pounds, manual dexterity, prolonged computer use, and the ability to work in a manufacturing environment.
See All 84 Operations Supervisor Jobs in North Carolina
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Find Operations Supervisor JobsOperations Supervisor Jobs by City in North Carolina
Where North Carolina roles are concentrated, by current openings.
Operations Supervisor Job Market in North Carolina
A snapshot from current North Carolina openings, updated as new roles post.
Who's Hiring


Top Industries Hiring
- Insurance
- Sports & Recreation
What North Carolina Employers Look For
The qualifications that appear most often in operations supervisor jobs across North Carolina.
- Three to five years of supervisory experience in manufacturing, logistics, or distribution operations
- Bachelor's degree in operations management, business administration, or a related field preferred
- Demonstrated experience managing production schedules, KPIs, and continuous improvement initiatives
- Proficiency with warehouse or manufacturing management systems such as SAP or Oracle
- Strong working knowledge of OSHA safety standards and North Carolina workplace safety requirements
- Lean or Six Sigma certification, such as Yellow Belt or Green Belt, increasingly requested by employers
Operations Supervisor Jobs in North Carolina: Frequently Asked Questions
How do you become a operations supervisor in North Carolina?
Most operations supervisors in North Carolina begin in frontline production, warehouse, or logistics roles before advancing into supervision. North Carolina does not require a state-issued license to work as an operations supervisor in most industries, but employers across the Charlotte metro, Triad, and Research Triangle consistently expect a combination of industry experience, a bachelor's degree or equivalent, and credentials like Lean or Six Sigma certification. Some manufacturing employers run internal leadership development programs that serve as a structured path into supervisory roles.
Which companies hire operations supervisors in North Carolina?
Companies currently hiring operations supervisors in North Carolina include Harrison, Walker and Harper, Advocate Aurora Health, and Lowe's Home Improvement, per current listings on Migrate Mate as of September 2026. North Carolina's heavy concentration of advanced manufacturing, logistics hubs, and distribution centers means demand is broad, with large employers anchoring hiring in the Charlotte, Greensboro, and Raleigh-Durham corridors.
Which North Carolina cities have the most operations supervisor jobs?
Charlotte, Greenville, and Raleigh account for the largest share of operations supervisor openings in North Carolina. Charlotte drives the most volume as the state's largest city and a major logistics and corporate hub, while Greensboro and the surrounding Triad benefit from a dense network of manufacturing plants and distribution facilities, and Raleigh-Durham's growth in life sciences and technology has expanded demand for operations leadership in those sectors.
Are there remote operations supervisor jobs in North Carolina?
Yes, but they're rare. Operations supervisor roles are predominantly on-site by nature, requiring direct oversight of production floors, distribution centers, or facilities teams. About 13% of operations supervisor openings tied to North Carolina are remote or hybrid as of September 2026, and those positions tend to involve multi-site coordination, administrative oversight, or roles in tech-adjacent operations where physical presence is less critical.
How can I get hired as a operations supervisor in North Carolina with little or no experience?
The most realistic entry path is landing a team lead or shift lead role within a large North Carolina manufacturer or distribution center, then building toward a supervisor title from within. Employers like Honeywell, Lowe's, and major third-party logistics operators based in Charlotte and Greensboro regularly hire associates and leads with the expectation of internal promotion. Completing a Lean or Six Sigma Yellow Belt certification and gaining experience with inventory or workforce management software strengthens candidacy significantly for candidates without prior supervisory titles.
Where can I find and apply to operations supervisor jobs in North Carolina?
You can find and apply to operations supervisor jobs in North Carolina on Migrate Mate, which lists current openings across the state. Search the listings, find roles that match your experience and target location, and apply directly to the ones that fit.
See All 84 Operations Supervisor Jobs in North Carolina
Find roles in North Carolina that match your experience and apply in just a few clicks.
Find Operations Supervisor Jobs