Human Resources Specialist Jobs in Minnesota
Human Resources Specialist jobs in Minnesota are concentrated in the Twin Cities metro, with additional hiring in Rochester and Duluth, where large employers like Mayo Clinic, Target, and UnitedHealth Group maintain substantial HR functions across benefits administration, talent acquisition, and employee relations. The market supports roles from entry-level HR coordinators through senior specialists focused on compliance and workforce planning. Minnesota's mix of Fortune 500 headquarters, major healthcare systems, and manufacturing anchors creates steady demand for specialists across multiple disciplines. See the openings below and apply to the ones that match your experience.
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POSITION SUMMARY
The Senior HR Business Partner (Sr. HRBP) serves as a strategic and hands-on partner to leaders across Nucleus RadioPharma, helping to build the people infrastructure needed to scale a fast-growing, GMP-regulated radiopharmaceutical organization. This role owns full-spectrum HR partnership – talent, employee relations, performance, organizational design, HR operations, and policy – ensuring HR practices are consistent, compliant, and aligned to Nucleus's operating rhythm.
This is a builder role as much as a partner role: the Sr. HRBP will help stand up scalable HR processes and frameworks appropriate for a ~55-person startup operating in an IND/FDA-regulated, GMP environment, while maintaining the flexibility and responsiveness leaders expect at this stage of growth.
PRINCIPAL RESPONSIBILITIES
HR Business Partnership
- Serve as the primary day-to-day HR partner for assigned leaders and employees, providing practical guidance on employee relations, performance management, attendance, workplace concerns, team dynamics, and policy application.
- Meet regularly with leaders to review staffing needs, employee performance, open positions, retention risks, organizational changes, and emerging people issues. Track agreed-upon actions through completion.
- Translate business and operational priorities into specific HR actions, including hiring plans, onboarding, training, performance expectations, development plans, succession planning, and employee communications.
- Support organizational changes by drafting job descriptions, teaching, coaching and clarifying responsibilities, evaluating reporting relationships, updating organizational charts, and coordinating employee communications and implementation steps.
- Partner with leaders to identify workforce gaps, develop staffing plans, and ensure the organization has the appropriate roles, capabilities, and coverage to support operational and regulatory requirements.
- Coach managers on setting clear expectations, providing timely feedback, documenting performance concerns, developing corrective action plans, and addressing issues consistently and promptly.
- Monitor employee trends, including turnover, engagement, absenteeism, performance concerns, and staffing levels, and recommend specific actions based on the data.
- Coordinate closely with Talent Acquisition, Payroll, Benefits, Legal, and HR Operations to ensure employee matters and organizational changes are implemented accurately and on time.
Employee Relations & Compliance
- Manage, coach on employee relations matters with sound judgment, consistency, and appropriate documentation, escalating and coordinating with leadership as needed.
- Ensure HR policies, practices, and documentation meet the standards required in a GMP and FDA-regulated environment.
- Maintain compliant, audit-ready HR documentation and recordkeeping practices.
Talent Management & Performance
- Support onboarding and workforce planning efforts in partnership with hiring managers as Nucleus scales.
- Facilitate performance management processes, including goal-setting, feedback cycles, and performance improvement support.
- Partner with leaders on succession planning, career pathing, and talent development for key roles.
Recruiting & Talent Acquisition
- Own full-cycle recruiting for assigned functions – intake, job posting, sourcing, screening, interviewing, and offer negotiation – in partnership with hiring managers.
- Build and maintain a scalable recruiting process and candidate pipeline appropriate for a fast-growing, GMP-regulated organization.
- Partner with hiring managers to define role requirements, build structured interview plans, and calibrate candidate evaluation criteria.
- Ensure recruiting practices, interview documentation, and offer processes meet compliance and audit-readiness standards.
- Manage the candidate experience end-to-end, ensuring timely communication and a smooth handoff into onboarding.
- Track recruiting metrics (e.g., time-to-fill, pipeline health) and report on hiring progress to support workforce planning and leadership visibility.
- Support employer branding and sourcing strategies to attract talent in a competitive life sciences/radiopharmaceutical labor market.
HR Operations
- Own day-to-day HR operations, including HRIS data integrity, employee records, and personnel file management.
- Administer onboarding and offboarding logistics, ensuring a consistent, compliant experience for new hires and departing employees.
- Maintain and administer HR policies and the employee handbook, ensuring version control and timely updates.
- Own benefits administration, including enrollment, eligibility, and day-to-day employee questions, in partnership with brokers/vendors.
- Lead annual open enrollment: coordinate timelines, communications, and vendor logistics, and ensure employees have the information needed to make informed elections.
- Maintain headcount tracking, org charts, and reporting for leadership visibility.
- Ensure HR operational processes and recordkeeping meet GMP/FDA audit-readiness standards.
QUALIFICATIONS & REQUIREMENTS
Required:
- Bachelor’s Degree in Business Administration, Psychology or another related field
- 5+ years of experience as an HR Business Partner or similar HR generalist/strategic role.
- 3+ years of full cycle recruiting experience
- Demonstrated experience managing employee relations matters with discretion and sound judgment.
- Experience owning HR operations, including HRIS administration, records management, onboarding/offboarding, and benefits/open enrollment administration.
- Strong written and verbal communication skills; comfortable partnering with senior leadership.
- Ability to operate with both strategic perspective and hands-on execution in a fast-paced, resource-lean environment.
- Ability to work onsite in Rochester, MN, with 1–2 trips per month to other Nucleus onsite locations
- Strong verbal and written communication skills.
- Demonstrated problem-solving and interpersonal skills, utilizing resourceful thinking and strong empathy.
- Ability to foster an inclusive and cooperative work environment.
Preferred:
- Experience in a life sciences, pharmaceutical, biotech, or GMP-regulated environment.
- Familiarity with FDA/IND regulatory context as it pertains to workforce and documentation requirements.
- Experience with HRIS platforms and HR operations tools.
- SHRM-CP/SCP, PHR/SPHR, or equivalent certification
- Comfort using AI-enabled HR and HRIS tools to improve efficiency, with sound judgment about human review of any compliance-sensitive or employee-facing output.
- Experience with HR strategy and tactical HR operations work spanning both fields.
- Strong employee relations focus, with demonstrated experience handling complex or sensitive matters independently
Ideal:
- Experience with HR Strategy and Tactical HR Operation work
- Strong employee relations focus
- HRIS Experience
COMPENSATION & BENEFITS
The salary range for this role in Minnesota is $110,00-$135,000 per year. Please note that compensation may vary outside of this range depending on several factors, including but not limited to a candidate’s qualifications, skills, competencies, and experience.
Benefit packages for this role include medical, dental, and vision insurance, as well as a Health Savings Account or Flexible Spending Account options (depending on the plan chosen), and 401k retirement account access with employer matching. Team members in this role are also entitled to paid sick leave and/or other paid time off in compliance with applicable law. Relocation assistance is available to qualified team members.
This job description is a summary of the typical functions of the position, not necessarily an exhaustive or comprehensive list of all possible position responsibilities, tasks, and duties. The company reserves the right to assign or reassign duties and responsibilities to this job at any time. This job does not constitute a written or implied contract of employment; employment remains “at-will.”
Nucleus RadioPharma is an equal opportunity employer and believes everyone deserves respect, dignity, and equality. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran, or disability status.
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Human Resources Specialist Job Market in Minnesota
A snapshot from current Minnesota openings, updated as new roles post.
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What Minnesota Employers Look For
The qualifications that appear most often in human resources specialist jobs across Minnesota.
- Bachelor's degree in human resources, business administration, or a closely related field
- PHR or SHRM-CP certification preferred or required for mid-level and senior roles
- Two or more years of experience in HR administration, recruiting, or employee relations
- Working knowledge of Minnesota employment law, including MPLA and MHRA compliance
- Proficiency with HRIS platforms such as Workday, SAP SuccessFactors, or ADP
- Strong communication skills for conducting investigations, trainings, and onboarding sessions
Human Resources Specialist Jobs in Minnesota: Frequently Asked Questions
How do you become a human resources specialist in Minnesota?
Most human resources specialist roles in Minnesota require a bachelor's degree in human resources, business, or a related field. Minnesota does not require a state-issued license to work in HR, but employers widely expect professional certification. The SHRM-CP from the Society for Human Resource Management or the PHR from HRCI are the most recognized credentials in the Minnesota market and significantly strengthen a candidate's application for specialist-level roles.
How much do human resources specialists make in Minnesota?
Human resources specialists in Minnesota earn a median of about $78,760 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $50,330 for the lowest 10% to over $127,060 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire human resources specialists in Minnesota?
Employers hiring human resources specialists in Minnesota right now include Loram, Presbyterian Homes & Services, and Cintas, based on current listings on Migrate Mate as of September 2026. Minnesota's concentration of Fortune 500 headquarters, large healthcare systems, and regional manufacturers means HR specialist demand is spread across multiple industries rather than a single sector.
Which Minnesota cities have the most human resources specialist jobs?
Minneapolis, Saint Paul, and Hamel account for the most human resources specialist openings in Minnesota. The Twin Cities metro dominates due to its density of corporate headquarters, major healthcare networks, and financial services firms, while Rochester's concentration of Mayo Clinic operations drives consistent HR hiring in that market, and Duluth draws from regional healthcare and manufacturing employers.
Are there remote human resources specialist jobs in Minnesota?
Yes, and more than many office roles, since much of HR specialist work involves documentation, system management, and virtual communication that translates well to remote settings. About 63% of human resources specialist openings tied to Minnesota are remote or hybrid as of September 2026, reflecting broader adoption across Twin Cities employers. Employee relations investigations, onboarding coordination, and benefits administration are the sub-functions most commonly offered in remote or hybrid arrangements.
How can I get hired as a human resources specialist in Minnesota with little or no experience?
The most realistic entry path is an HR coordinator or HR assistant role, which Minnesota employers including large healthcare systems, retailers, and manufacturers use to develop early-career HR professionals. Target, Fairview Health Services, and similar large Minnesota organizations run structured internship and new-grad programs that feed into specialist pipelines. Candidates transitioning from adjacent roles in payroll, office administration, or customer service are competitive when they pair that experience with an active SHRM student membership or a completed SHRM-CP exam, which demonstrates formal HR knowledge even without direct specialist experience.
Where can I find and apply to human resources specialist jobs in Minnesota?
You can find and apply to human resources specialist jobs in Minnesota on Migrate Mate, which lists current openings tied to the state. Search for roles that match your experience level and specialization, then apply directly to the listings that fit.
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