Clinic Registered Nurse Jobs in South Carolina
Clinic Registered Nurse jobs in South Carolina draw consistent demand across outpatient clinics, physician group practices, and federally qualified health centers, with openings available from new graduate to experienced specialty nurse. Columbia, Greenville, and Charleston anchor the largest share of hiring, where major systems such as Prisma Health, MUSC Health, and Bon Secours St. Francis regularly staff clinic RN roles. Ambulatory care, primary care, and chronic disease management are the most active specialties in the state right now. Scan the live roles below and apply to whichever ones fit.
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Showing 5 of 8+ Clinic Registered Nurse jobs
Thank you for considering a career at Roper St. Francis Healthcare!
HOURS:
7:00am - 4:00pm (may have occasional 3rd shift or 2nd shift coverage once per quarter)
LOCATION:
Boeing Welcome Center
Job Summary:
Provides patient care at Roper St. Francis Health Care sites, as assigned, using approved protocols. Facilitate the timely communication of clinical advice to patients electronically or by phone as directed by practice providers. Ensure all needed medical records are available to care teams and providers prior to patient’s office visit. Coordinate with other team members to provide exceptional patient service. The RN will receive training on the Electonic Health Record system (EHR).
Minimum Qualifications:
Education: Graduate of an accredited nursing school.
Experience: One to two years RN experience, preferable.
Licensure/Certification: Currently licensed as a Registered Nurse in the State of South Carolina or holds a current compact/multi-state license as a Registered Nurse in a recognized NCSBN Compact State and is not a permanent resident of SC. Must have a current American Heart Association BLS for Healthcare Provider Card.
Primary Source Verification: Yes – http://www.llr.state.sc.us/ or compact RN state licensing board.
Knowledge/Skills: Requires the ability to use clinical equipment including EKG machine, spirometer, Hemocue, Pulse Oxymeter. Must have basic knowledge of medication policy and procedure and effectively utilize assessment skills for triage and patient care. Must be able to assist physician with outpatient office procedures. Strong patient-centered focus. Effective verbal and written communication skills. Ability to establish and maintain effective working relationships with patients, employees and the public. Ability to organize and manage competing priorities. Ability to problem solve and show good judgment.
Other:
Contacts: Patients, physicians, other staff members of the healthcare system.
Work Demands/Environment:
Intermittent standing. Intermittent walking. Intermittent sitting. May require lifting or moving items up to 50 lbs. Intermittent lifting/moving patients. Intermittent use of finger/hand dexterity. Frequent reaching with hands/arms. Corrected hearing and vision to normal range. Exposure to blood, body fluids or tissue. Possible exposure to infectious materials, communicable diseases, toxic substances, ionizing radiation, medicinal preparations and/or other conditions common to a physician office environment. Normal medical office environment. Ability to read and comprehend. May be required to take call and/or work weekends/holidays based on the needs of the department. Requires work under stressful conditions, deadlines, and/or irregular hours.
As a Roper St. Francis Healthcare teammate, you're part of a Mission that matters. We support your well-being—personally and professionally. Our benefits are built to grow with you and meet your unique needs, every step of the way.
What we offer
- Competitive pay, incentives, referral bonuses and 403(b) with employer contributions (when eligible)
- Medical, dental, vision, prescription coverage, HSA/FSA options, life insurance, mental health resources and discounts
- Paid time off, parental and FMLA leave, short- and long-term disability
- Tuition assistance, professional development and continuing education support
Benefits may vary based on the market and employment status
Roper St. Francis Healthcare is an equal opportunity employer.
It is our policy to abide by all Federal and State laws, as well as, the requirements of 41 CFR 60-1.4(a), 60-300.5(a) and 60-741.5(a).Accordingly, all applicants will receive consideration for employment without regard to race, color, national origin, religion, sex, sexual orientation, gender identity, age, genetic information, or protected veteran status, and will not be discriminated against on the basis of disability. If you are an individual with a disability and would like to request a reasonable accommodation as part of the employment selection process, please contact The Talent Acquisition Team at recruitment@RSFH.com
Thank you for considering a career at Roper St. Francis Healthcare!
HOURS:
7:00am - 4:00pm (may have occasional 3rd shift or 2nd shift coverage once per quarter)
LOCATION:
Boeing Welcome Center
Job Summary:
Provides patient care at Roper St. Francis Health Care sites, as assigned, using approved protocols. Facilitate the timely communication of clinical advice to patients electronically or by phone as directed by practice providers. Ensure all needed medical records are available to care teams and providers prior to patient’s office visit. Coordinate with other team members to provide exceptional patient service. The RN will receive training on the Electonic Health Record system (EHR).
Minimum Qualifications:
Education: Graduate of an accredited nursing school.
Experience: One to two years RN experience, preferable.
Licensure/Certification: Currently licensed as a Registered Nurse in the State of South Carolina or holds a current compact/multi-state license as a Registered Nurse in a recognized NCSBN Compact State and is not a permanent resident of SC. Must have a current American Heart Association BLS for Healthcare Provider Card.
Primary Source Verification: Yes – http://www.llr.state.sc.us/ or compact RN state licensing board.
Knowledge/Skills: Requires the ability to use clinical equipment including EKG machine, spirometer, Hemocue, Pulse Oxymeter. Must have basic knowledge of medication policy and procedure and effectively utilize assessment skills for triage and patient care. Must be able to assist physician with outpatient office procedures. Strong patient-centered focus. Effective verbal and written communication skills. Ability to establish and maintain effective working relationships with patients, employees and the public. Ability to organize and manage competing priorities. Ability to problem solve and show good judgment.
Other:
Contacts: Patients, physicians, other staff members of the healthcare system.
Work Demands/Environment:
Intermittent standing. Intermittent walking. Intermittent sitting. May require lifting or moving items up to 50 lbs. Intermittent lifting/moving patients. Intermittent use of finger/hand dexterity. Frequent reaching with hands/arms. Corrected hearing and vision to normal range. Exposure to blood, body fluids or tissue. Possible exposure to infectious materials, communicable diseases, toxic substances, ionizing radiation, medicinal preparations and/or other conditions common to a physician office environment. Normal medical office environment. Ability to read and comprehend. May be required to take call and/or work weekends/holidays based on the needs of the department. Requires work under stressful conditions, deadlines, and/or irregular hours.
As a Roper St. Francis Healthcare teammate, you're part of a Mission that matters. We support your well-being—personally and professionally. Our benefits are built to grow with you and meet your unique needs, every step of the way.
What we offer
- Competitive pay, incentives, referral bonuses and 403(b) with employer contributions (when eligible)
- Medical, dental, vision, prescription coverage, HSA/FSA options, life insurance, mental health resources and discounts
- Paid time off, parental and FMLA leave, short- and long-term disability
- Tuition assistance, professional development and continuing education support
Benefits may vary based on the market and employment status
Roper St. Francis Healthcare is an equal opportunity employer.
It is our policy to abide by all Federal and State laws, as well as, the requirements of 41 CFR 60-1.4(a), 60-300.5(a) and 60-741.5(a).Accordingly, all applicants will receive consideration for employment without regard to race, color, national origin, religion, sex, sexual orientation, gender identity, age, genetic information, or protected veteran status, and will not be discriminated against on the basis of disability. If you are an individual with a disability and would like to request a reasonable accommodation as part of the employment selection process, please contact The Talent Acquisition Team at recruitment@RSFH.com
See All 8 Clinic Registered Nurse Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find Clinic Registered Nurse JobsClinic Registered Nurse Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
Clinic Registered Nurse Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring
Top Industries Hiring
- Healthcare & Medical Services
What South Carolina Employers Look For
The qualifications that appear most often in clinic registered nurse jobs across South Carolina.
- Active Registered Nurse license issued or recognized by the South Carolina Board of Nursing
- Associate or Bachelor of Science in Nursing degree from an accredited program
- Current BLS certification and CPR card from an accredited provider
- Minimum one year of clinical nursing experience in an ambulatory or outpatient setting
- Proficiency with electronic health record systems such as Epic or Cerner
- Strong patient triage and care coordination skills in a high-volume clinic environment
Clinic Registered Nurse Jobs in South Carolina: Frequently Asked Questions
How do you become a clinic registered nurse in South Carolina?
You become a clinic registered nurse in South Carolina by earning an Associate Degree in Nursing or a Bachelor of Science in Nursing from an accredited program, passing the NCLEX-RN exam, and obtaining licensure through the South Carolina Board of Nursing. South Carolina participates in the Nurse Licensure Compact, so nurses licensed in other compact states may practice here without a separate state license, though you must verify your license status with the Board directly.
How much do clinic registered nurses make in South Carolina?
Clinic registered nurses in South Carolina earn a median of about $82,360 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $66,860 for the lowest 10% to over $106,520 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire clinic registered nurses in South Carolina?
Companies currently hiring clinic registered nurses in South Carolina include Prisma Health, Your Health Organization, and Aiken Regional Medical Centers, per current listings on Migrate Mate as of August 2026. South Carolina's major integrated health systems and federally qualified health centers generate the most consistent clinic RN openings, particularly in the Midlands and Upstate regions.
Which South Carolina cities have the most clinic registered nurse jobs?
Aiken, Greenville, and Rock Hill have the most clinic registered nurse openings in South Carolina. Columbia leads as the state capital and home to the largest Prisma Health campus, while Greenville's rapid population growth and MUSC Health's Upstate expansion drive strong demand there, and Charleston's concentration of academic medical and specialty outpatient centers sustains steady hiring.
How can I get hired as a clinic registered nurse in South Carolina with little or no experience?
The most realistic entry path is a new graduate or nurse residency program offered by large South Carolina health systems such as Prisma Health or MUSC Health, which provide structured clinical orientation for RNs with limited post-graduation experience. Entry-level clinic roles in school health services, public health departments, and federally qualified health centers across the state also regularly hire new graduates. Holding an active South Carolina Board of Nursing license, BLS certification, and any ambulatory clinical hours from nursing school practicum rotations strengthens a first application considerably.
Where can I find and apply to clinic registered nurse jobs in South Carolina?
You can find and apply to clinic registered nurse jobs in South Carolina on Migrate Mate, which lists current South Carolina openings in one place. Search through the roles available, find the ones that match your experience and preferred location, and apply directly to the ones that fit.
See All 8 Clinic Registered Nurse Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find Clinic Registered Nurse Jobs