COO Jobs in South Carolina

COO jobs in South Carolina are concentrated in Columbia, Charleston, and Greenville, where anchor employers like Prisma Health, Michelin North America, and Santee Cooper maintain deep operational leadership needs. Demand runs strongest in healthcare operations, advanced manufacturing, and financial services, with openings at both the divisional and enterprise level. The market rewards executives who can manage multi-site teams and drive efficiency in regulated, production-intensive, or mission-driven environments. See the openings below and apply to the ones that match your experience.

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Overview

Open roles37
Top employerTrigo
Top cityCharleston, SC
Cities hiring16
Work type57% Hybrid
Top credentialBachelor's degree

Showing 5 of 37+ COO jobs

Director of Operations
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Added 2d ago
Director of Operations
Schnellecke Logistics
Ladson, South Carolina
Customer Service
Customer Support
Bachelor's degree
10,000+

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RN Director of Operations Hospice
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Added 3d ago
RN Director of Operations Hospice
Optum
Beaufort, South Carolina
Clinical Support
Healthcare Administration
Human Resources
$84k - $126k/yr
CPR Certification
10,000+

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RN Associate Director of Operations
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Added 3d ago
RN Associate Director of Operations
BAYADA Home Health Care
Columbia, South Carolina
Administrative & Office Support
Business Operations
Project Management
On-Site
10,000+

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Director of Operations - Remote, Online Education
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Added 1w ago
Director of Operations - Remote, Online Education
The Scholarship System
Charleston, South Carolina
Business Operations
Business Strategy
Project Management
$105k - $115k/yr
Remote (US)

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Home Health Administrator Director of Operations
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Added 2w ago
Home Health Administrator Director of Operations
PruittHealth
Rock Hill, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
Bachelor's degree
10,000+

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COO Jobs by City in South Carolina

Where South Carolina roles are concentrated, by current openings.

Charleston
8 jobs
Greenville
5 jobs
Greer
4 jobs
Columbia
3 jobs
Spartanburg
3 jobs
Lexington
2 jobs
Myrtle Beach
2 jobs
Ladson
1 job
Beaufort
1 job

COO Job Market in South Carolina

A snapshot from current South Carolina openings, updated as new roles post.

Who's Hiring

Trigo2 open roles
BHC1 open role
Optum1 open role

What South Carolina Employers Look For

The qualifications that appear most often in COO jobs across South Carolina.

  • Bachelor's degree in business administration, operations management, or a related field required
  • Ten or more years of progressive leadership experience in operations or general management
  • Demonstrated ability to build and lead cross-functional teams across multiple departments
  • Experience managing P&L responsibility and operating budgets in a complex organization
  • Strong background in process improvement methodologies such as Lean or Six Sigma
  • Excellent communication and board-level stakeholder engagement skills required

COO Jobs in South Carolina: Frequently Asked Questions

How do you become a coo in South Carolina?

Most coos in South Carolina reach the role after progressing through director and VP-level operations positions within their industry. South Carolina does not require a state-issued license for the coo title itself, but healthcare-sector coos at licensed facilities may need to satisfy South Carolina Department of Health and Environmental Control administrative requirements. An MBA or an advanced degree from an institution like the University of South Carolina or Clemson University strengthens candidacy at larger employers in the state.

Which companies hire coos in South Carolina?

South Carolina coo roles are posted by Trigo, BHC, and Optum and others right now, based on current listings on Migrate Mate as of November 2026. South Carolina's concentration of major healthcare systems, global manufacturers, and regional financial institutions means coo demand stays consistent well beyond individual hiring cycles.

Which South Carolina cities have the most coo jobs?

Charleston, Greenville, and Greer account for the most coo openings in South Carolina. Columbia anchors the healthcare and state government sectors, Charleston draws demand from logistics, technology, and hospitality employers near the port, and Greenville's advanced manufacturing base, led by Michelin, BMW, and a dense supplier network, generates steady need for operations executives in production-intensive environments.

Are there remote coo jobs in South Carolina?

Yes, but they're rare. About 71% of coo openings tied to South Carolina are remote or hybrid as of November 2026, reflecting the hands-on nature of most operations leadership roles in the state. Where remote arrangements do appear, they tend to involve oversight functions at multi-site organizations where strategic coordination rather than daily floor presence is the primary responsibility.

How can I get hired as a coo in South Carolina with little or no experience?

The most realistic path for someone without direct coo experience is a director of operations or VP of operations role at a mid-size South Carolina employer, which serves as the standard proving ground. Large health systems like Prisma Health and MUSC run formal leadership development programs that place high-performing managers on an executive track. Lateral moves from supply chain director, plant manager, or chief of staff roles are common entry points, and an MBA from a South Carolina program strengthens your case for an accelerated move.

Where can I find and apply to coo jobs in South Carolina?

You can find and apply to coo jobs in South Carolina on Migrate Mate, which lists current openings across the state updated regularly. Search the listings, identify the roles that fit your experience and industry background, and apply directly to the ones that align with where you are in your career.

See All 37 COO Jobs in South Carolina

Find roles in South Carolina that match your experience and apply in just a few clicks.

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