COO Jobs in South Carolina

COO jobs in South Carolina are open across Charleston, Columbia, and Greenville and other South Carolina metros, with employers like Medical University of South Carolina, University of South Carolina, and Lexington Health hiring at every experience level. Find a role that fits below and apply directly.

Find COO Jobs

Overview

Open roles303+
Top cityCharleston, SC
Cities hiring58
Work type96% On-site
Top industryHealthcare

Showing 5 of 303+ COO jobs

Southern Glazer’s Wine & Spirits
Pricing Coordinator
We won't show you this job again
Southern Glazer’s Wine & Spirits
New 2h ago
Pricing Coordinator
Southern Glazer’s Wine & Spirits
West Columbia, South Carolina
Business Operations
Customer Service & Support
Administrative & Office Support
On-Site
High School
10,000+

Have you applied for this role?

University of South Carolina
Development Coordinator
We won't show you this job again
University of South Carolina
New 7h ago
Development Coordinator
University of South Carolina
Richland, South Carolina
Administrative & Office Support
Customer Service & Support
Project & Program Management
$49k - $71k/yr
On-Site
Bachelor's
5,001-10,000

Have you applied for this role?

University of South Carolina
Research Program Coordinator
We won't show you this job again
University of South Carolina
New 8h ago
Research Program Coordinator
University of South Carolina
Richland, South Carolina
Research & Academia
Healthcare Administration
On-Site
Bachelor's
5,001-10,000

Have you applied for this role?

Gerber Childrenswear LLC
Social Media and Marketing Coordinator
We won't show you this job again
Gerber Childrenswear LLC
New 8h ago
Social Media and Marketing Coordinator
Gerber Childrenswear LLC
Greenville, South Carolina
Brand & Social Media
Content & Communications
Marketing
Social Media Management
Content Marketing
Brand Marketing
On-Site
Bachelor's

Have you applied for this role?

Lexington Health
Scheduling Coordinator
We won't show you this job again
Lexington Health
Added 2d ago
Scheduling Coordinator
Lexington Health
West Columbia, South Carolina
Customer Service & Support
Healthcare Administration
Customer Service
On-Site
High School
5,001-10,000

Have you applied for this role?

See All 303+ COO Jobs in South Carolina

Find roles in South Carolina that match your experience and apply in just a few clicks.

Find COO Jobs

COO Jobs by City in South Carolina

Where South Carolina roles are concentrated, by current openings.

Charleston
72 jobs
Columbia
31 jobs
Greenville
21 jobs
Richland
18 jobs
West Columbia
15 jobs
Florence
13 jobs
Bluffton
12 jobs
Spartanburg
9 jobs
Myrtle Beach
8 jobs

COO Job Market in South Carolina

A snapshot from current South Carolina openings, updated as new roles post.

Who's Hiring

  • Medical University of South Carolina
    Medical University of South Carolina58
  • University of South Carolina
    University of South Carolina23
  • Lexington Health
    Lexington Health20
  • Prisma Health
    Prisma Health12
  • Rehab Employee Services
    Rehab Employee Services11

Top Industries Hiring

  • Healthcare & Medical Services108
  • Education61
  • Hospitality & Tourism22
  • Construction & Real Estate11
  • Food & Beverage11

What South Carolina Employers Look For

The qualifications that appear most often in COO jobs across South Carolina.

  • 10 or more years of progressive operational leadership experience
  • Demonstrated P&L ownership across a full business unit or company
  • Experience scaling teams and building cross-functional processes
  • Strong financial acumen including budgeting, forecasting, and reporting
  • Proven ability to translate strategy into executable operational plans
  • Bachelor's degree required, MBA or equivalent advanced degree preferred

COO Jobs in South Carolina: Frequently Asked Questions

How many COO jobs are there in South Carolina?

There are 303+ COO openings in South Carolina on Migrate Mate as of June 2026, with the most roles in Charleston, Columbia, and Greenville. New positions post regularly as employers across South Carolina hire.

Which South Carolina cities have the most COO jobs?

Charleston, Columbia, and Greenville have the most COO openings in South Carolina right now, with additional roles spread across smaller metros statewide.

Which companies hire COOs in South Carolina?

Employers hiring COOs in South Carolina include Medical University of South Carolina, University of South Carolina, and Lexington Health, based on current listings on Migrate Mate as of June 2026.

Are there remote COO jobs in South Carolina?

Yes. About 4% of COO openings tied to South Carolina are remote or hybrid as of June 2026. The rest are on-site roles based in South Carolina metros.

How do I apply for COO jobs in South Carolina?

You can apply to COO jobs in South Carolina directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred South Carolina location, then apply to each one that fits.

See All 303+ COO Jobs in South Carolina

Find roles in South Carolina that match your experience and apply in just a few clicks.

Find COO Jobs