COO Jobs in South Carolina
COO jobs in South Carolina are concentrated in Columbia, Charleston, and Greenville, where anchor employers like Prisma Health, Michelin North America, and Santee Cooper maintain deep operational leadership needs. Demand runs strongest in healthcare operations, advanced manufacturing, and financial services, with openings at both the divisional and enterprise level. The market rewards executives who can manage multi-site teams and drive efficiency in regulated, production-intensive, or mission-driven environments. See the openings below and apply to the ones that match your experience.
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Showing 5 of 40+ COO jobs
Inspire health. Serve with compassion. Be the difference.
Job Summary
Provides advanced administrative support of a widely varied and complex nature. Uses Microsoft Office applications extensively to perform complex functions. Handles highly confidential information and unique situations. Coordinates the work of clerical employees when necessary. Interacts with all levels of internal and external customers, including community leaders. Handles multiple complex projects, some of which are multi-departmental or involve external entities. Works independently and exercises considerable discretion and independent judgment.Essential Functions
All team members are expected to be knowledgeable and compliant with Prisma Health's purpose: Inspire health. Serve with compassion. Be the difference.
Answers and addresses incoming calls. Directs callers to other personnel as needed. Appropriately determines the urgency of each call and advises the Vice President when necessary. Suggests appropriate referrals. Returns calls as directed by the Vice President.
Schedules appointments. Keeps Vice President apprised of calendar events. Reminds and/or assists with required preparation for meetings and appointments. Coordinates travel arrangements and catering as necessary.
Handles mail, organizes flow of work and paper and flags paperwork
Maintains files and security of confidential information.
Performs delegated executive functions. Makes decisions within authorized scope or directing the decision making to the proper authority.
Coordinates staff meetings and maintains conference room meeting schedule. Prepares and distributes agendas and minutes.
Composes correspondence, memos, and reports. Types, formats and proofreads a variety of material
Monitors department budget. Maintains equipment and supplies.
Serves as timekeeper for the assigned area. Keys in timekeeping adjustments for payroll purposes each pay period.
Performs other duties as assigned.
Supervisory/Management Responsibility
This is a non-management job that will report to a supervisor, manager, director or executive.
Minimum Requirements
Education - High School diploma or equivalent OR post high school diploma / highest degree earned. Post High School courses in Computers or Office Technology preferred
Experience - Five (5) administrative experience
In Lieu Of
NA
Required Certifications, Registrations, Licenses
NA
Knowledge, Skills and Abilities
Ability to use e-mail and perform scheduling functions
Presentation skills (with graphics)
Work Shift
Day (United States of America)Location
Prisma Health Corporate OfficeFacility
7001 CorporateDepartment
70019023 President's OfficeShare your talent with us! Our vision is simple: to transform healthcare for the benefits of the communities we serve. The transformation of healthcare requires talented individuals in every role here at Prisma Health.
Inspire health. Serve with compassion. Be the difference.
Job Summary
Provides advanced administrative support of a widely varied and complex nature. Uses Microsoft Office applications extensively to perform complex functions. Handles highly confidential information and unique situations. Coordinates the work of clerical employees when necessary. Interacts with all levels of internal and external customers, including community leaders. Handles multiple complex projects, some of which are multi-departmental or involve external entities. Works independently and exercises considerable discretion and independent judgment.Essential Functions
All team members are expected to be knowledgeable and compliant with Prisma Health's purpose: Inspire health. Serve with compassion. Be the difference.
Answers and addresses incoming calls. Directs callers to other personnel as needed. Appropriately determines the urgency of each call and advises the Vice President when necessary. Suggests appropriate referrals. Returns calls as directed by the Vice President.
Schedules appointments. Keeps Vice President apprised of calendar events. Reminds and/or assists with required preparation for meetings and appointments. Coordinates travel arrangements and catering as necessary.
Handles mail, organizes flow of work and paper and flags paperwork
Maintains files and security of confidential information.
Performs delegated executive functions. Makes decisions within authorized scope or directing the decision making to the proper authority.
Coordinates staff meetings and maintains conference room meeting schedule. Prepares and distributes agendas and minutes.
Composes correspondence, memos, and reports. Types, formats and proofreads a variety of material
Monitors department budget. Maintains equipment and supplies.
Serves as timekeeper for the assigned area. Keys in timekeeping adjustments for payroll purposes each pay period.
Performs other duties as assigned.
Supervisory/Management Responsibility
This is a non-management job that will report to a supervisor, manager, director or executive.
Minimum Requirements
Education - High School diploma or equivalent OR post high school diploma / highest degree earned. Post High School courses in Computers or Office Technology preferred
Experience - Five (5) administrative experience
In Lieu Of
NA
Required Certifications, Registrations, Licenses
NA
Knowledge, Skills and Abilities
Ability to use e-mail and perform scheduling functions
Presentation skills (with graphics)
Work Shift
Day (United States of America)Location
Prisma Health Corporate OfficeFacility
7001 CorporateDepartment
70019023 President's OfficeShare your talent with us! Our vision is simple: to transform healthcare for the benefits of the communities we serve. The transformation of healthcare requires talented individuals in every role here at Prisma Health.
See All 40 COO Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find COO JobsCOO Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
COO Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring
Top Industries Hiring
- Banking & Financial Services
- Hospitality & Tourism
- Construction & Real Estate
- Government & Public Sector
- Consulting & Professional Services
What South Carolina Employers Look For
The qualifications that appear most often in COO jobs across South Carolina.
- Bachelor's degree in business administration, operations management, or a related field required
- Ten or more years of progressive leadership experience in operations or general management
- Demonstrated ability to build and lead cross-functional teams across multiple departments
- Experience managing P&L responsibility and operating budgets in a complex organization
- Strong background in process improvement methodologies such as Lean or Six Sigma
- Excellent communication and board-level stakeholder engagement skills required
COO Jobs in South Carolina: Frequently Asked Questions
How do you become a coo in South Carolina?
Most coos in South Carolina reach the role after progressing through director and VP-level operations positions within their industry. South Carolina does not require a state-issued license for the coo title itself, but healthcare-sector coos at licensed facilities may need to satisfy South Carolina Department of Health and Environmental Control administrative requirements. An MBA or an advanced degree from an institution like the University of South Carolina or Clemson University strengthens candidacy at larger employers in the state.
Which companies hire coos in South Carolina?
South Carolina coo roles are posted by AMIkids, COLLEGE OF CHARLESTON, and Cornerstone Caregiving and others right now, based on current listings on Migrate Mate as of August 2026. South Carolina's concentration of major healthcare systems, global manufacturers, and regional financial institutions means coo demand stays consistent well beyond individual hiring cycles.
Which South Carolina cities have the most coo jobs?
Greenville, Charleston, and Columbia account for the most coo openings in South Carolina. Columbia anchors the healthcare and state government sectors, Charleston draws demand from logistics, technology, and hospitality employers near the port, and Greenville's advanced manufacturing base, led by Michelin, BMW, and a dense supplier network, generates steady need for operations executives in production-intensive environments.
Are there remote coo jobs in South Carolina?
Yes, but they're rare. About 13% of coo openings tied to South Carolina are remote or hybrid as of August 2026, reflecting the hands-on nature of most operations leadership roles in the state. Where remote arrangements do appear, they tend to involve oversight functions at multi-site organizations where strategic coordination rather than daily floor presence is the primary responsibility.
How can I get hired as a coo in South Carolina with little or no experience?
The most realistic path for someone without direct coo experience is a director of operations or VP of operations role at a mid-size South Carolina employer, which serves as the standard proving ground. Large health systems like Prisma Health and MUSC run formal leadership development programs that place high-performing managers on an executive track. Lateral moves from supply chain director, plant manager, or chief of staff roles are common entry points, and an MBA from a South Carolina program strengthens your case for an accelerated move.
Where can I find and apply to coo jobs in South Carolina?
You can find and apply to coo jobs in South Carolina on Migrate Mate, which lists current openings across the state updated regularly. Search the listings, identify the roles that fit your experience and industry background, and apply directly to the ones that align with where you are in your career.
See All 40 COO Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
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