STEM OPT Jobs in Massachusetts
Massachusetts is one of the densest F-1 STEM OPT markets in the country, with employer concentration in biotech, life sciences, software, and engineering across Greater Boston, Cambridge, and the Route 128 corridor. Universities like MIT and Harvard feed a pipeline that employers here are built to absorb.
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Get Access To All JobsCOMPANY INTRODUCTION
Triveni Bio is breaking new ground in the identification of novel disease targets – working at the convergence of human genetics, best-in-class antibody design, and precision medicine. We are pioneering a Mendelian genetics-informed precision medicine approach to develop functional antibodies for the treatment of immunological and inflammatory (I&I) disorders. Our lead antibody program (TRIV-509) targets kallikreins 5 and 7 (KLK5/7) to directly impact skin barrier function, inflammation, and itch – providing a meaningful and much needed potential treatment option for patients with atopic dermatitis and other barrier disorders. In all the work we do, we adhere to our core values: patient impact, bold and rigorous science, open collaboration, kindness & respect.
SUMMARY
We are seeking a motivated, detail-oriented Senior Scientist to join our Clinical Pharmacology team. In this hands-on role, you will contribute directly to data analysis, modeling, and operational tracking across our clinical-stage and pipeline programs. Working closely with cross-functional teams, you will perform non-compartmental analyses (NCA), population PK/PD modeling, help define and implement bioanalytical strategies, manage bioanalytical data, and actively participate in clinical study team meetings. This is an exciting opportunity for an early-career scientist with 2–3 years of experience looking to expand their skills in hands-on quantitative clinical pharmacology and biologic drug development. Reporting into the Exec. Director, Clinical Pharmacology, and working closely with Clinical Development, Translational Medicine, Biometrics, Regulatory Affairs, and external partners, the Senior Scientist will help generate data and insights that inform dose selection, study design, and key development decisions.
Responsibilities
- Support the development and implementation of clinical pharmacology plans for clinical development programs
- Contribute to the design of PK, PD, biomarker, immunogenicity, and exposure-response assessments in clinical studies
- Perform Non-Compartmental Analysis (NCA) using standard software (e.g., Monolix or R) to support clinical study
- Execute data assembly, dataset generation, and preliminary quantitative analyses for Population PK/PD (popPK/PD) and exposure-response modeling using R, Monolix, or equivalent platforms
- Generate high-quality graphical visualizations and summary tables of clinical PK/PD for internal study team updates
- Attend and participate in cross-functional clinical study team meetings, representing the Clinical Pharmacology function
- Collaborate with internal teams and external vendors to ensure timely execution of clinical pharmacology analyses and deliverables
- Assist in the preparation and review of clinical study protocols, statistical analysis plans, clinical study reports, and other development documents
- Support the preparation of clinical pharmacology components of regulatory submissions and health authority responses
- Contribute to model-informed drug development activities and pharmacometric analyses through collaboration with internal and external experts
- Present study results and data interpretations to project teams and functional leadership
- Maintain knowledge of current scientific, regulatory, and industry trends in clinical pharmacology and pharmacometrics
- Other duties as assigned
EXPERIENCE & QUALIFICATIONS
- Ph.D. or M.S. in Clinical Pharmacology, Pharmaceutical Sciences, Pharmacometrics, Pharmacokinetics, Biomedical Sciences, or a related scientific discipline
- 2+ years (Ph.D.) or 5+ years (M.S.) years of relevant industry experience in biotechnology, pharmaceutical, or CRO environments; postdoctoral experience may be considered
- Proficiency with R for data manipulation, statistical reporting, and data visualization. Hands-on experience or academic exposure to pharmacometric platforms such as Monolix, or NONMEM
- Experience supporting clinical development programs, preferably involving biologics, antibodies, or immunology/inflammation therapeutics
- Knowledge of PK, PD, exposure-response relationships, immunogenicity assessments, and clinical pharmacology principles
- Experience working with external CROs and bioanalytical laboratories
- Strong scientific communication and data presentation skills
- Experience contributing to regulatory documentation is preferred
- Ability to travel up to 10% as needed
The posted range reflects the current reasonable and good faith estimate of the base salary for this full-time position. Actual compensation will be based on a variety of factors including, but not limited to, relevant skills and experience, educational background and certifications, performance and qualifications, market demand for the role, geographic location and other organizational needs. This role also offers a competitive target bonus, equity, and a comprehensive benefits package.
We are committed to fair pay practices, and we regularly review our compensation programs to ensure they are competitive, equitable, and aligned with our values. Please note that the advertised pay range is not a guarantee or promise of a specific wage.
Triveni Bio, along with other biotech companies, has become aware of a surge in email scams targeting prospective job candidates within our industry. Official Triveni Bio applications will always be submitted through Lever, our ATS. Any applications that take you to other platforms could be fraudulent. We do not use text or chat applications to conduct interviews or make job offers. Official Triveni Bio correspondence will always be conducted from email addresses ending in @triveni.bio or @hire.lever.co. Please disregard any other communications that do not originate from these domain names. If you receive any suspicious requests or communications, please verify their authenticity before responding.
COMPANY INTRODUCTION
Triveni Bio is breaking new ground in the identification of novel disease targets – working at the convergence of human genetics, best-in-class antibody design, and precision medicine. We are pioneering a Mendelian genetics-informed precision medicine approach to develop functional antibodies for the treatment of immunological and inflammatory (I&I) disorders. Our lead antibody program (TRIV-509) targets kallikreins 5 and 7 (KLK5/7) to directly impact skin barrier function, inflammation, and itch – providing a meaningful and much needed potential treatment option for patients with atopic dermatitis and other barrier disorders. In all the work we do, we adhere to our core values: patient impact, bold and rigorous science, open collaboration, kindness & respect.
SUMMARY
We are seeking a motivated, detail-oriented Senior Scientist to join our Clinical Pharmacology team. In this hands-on role, you will contribute directly to data analysis, modeling, and operational tracking across our clinical-stage and pipeline programs. Working closely with cross-functional teams, you will perform non-compartmental analyses (NCA), population PK/PD modeling, help define and implement bioanalytical strategies, manage bioanalytical data, and actively participate in clinical study team meetings. This is an exciting opportunity for an early-career scientist with 2–3 years of experience looking to expand their skills in hands-on quantitative clinical pharmacology and biologic drug development. Reporting into the Exec. Director, Clinical Pharmacology, and working closely with Clinical Development, Translational Medicine, Biometrics, Regulatory Affairs, and external partners, the Senior Scientist will help generate data and insights that inform dose selection, study design, and key development decisions.
Responsibilities
- Support the development and implementation of clinical pharmacology plans for clinical development programs
- Contribute to the design of PK, PD, biomarker, immunogenicity, and exposure-response assessments in clinical studies
- Perform Non-Compartmental Analysis (NCA) using standard software (e.g., Monolix or R) to support clinical study
- Execute data assembly, dataset generation, and preliminary quantitative analyses for Population PK/PD (popPK/PD) and exposure-response modeling using R, Monolix, or equivalent platforms
- Generate high-quality graphical visualizations and summary tables of clinical PK/PD for internal study team updates
- Attend and participate in cross-functional clinical study team meetings, representing the Clinical Pharmacology function
- Collaborate with internal teams and external vendors to ensure timely execution of clinical pharmacology analyses and deliverables
- Assist in the preparation and review of clinical study protocols, statistical analysis plans, clinical study reports, and other development documents
- Support the preparation of clinical pharmacology components of regulatory submissions and health authority responses
- Contribute to model-informed drug development activities and pharmacometric analyses through collaboration with internal and external experts
- Present study results and data interpretations to project teams and functional leadership
- Maintain knowledge of current scientific, regulatory, and industry trends in clinical pharmacology and pharmacometrics
- Other duties as assigned
EXPERIENCE & QUALIFICATIONS
- Ph.D. or M.S. in Clinical Pharmacology, Pharmaceutical Sciences, Pharmacometrics, Pharmacokinetics, Biomedical Sciences, or a related scientific discipline
- 2+ years (Ph.D.) or 5+ years (M.S.) years of relevant industry experience in biotechnology, pharmaceutical, or CRO environments; postdoctoral experience may be considered
- Proficiency with R for data manipulation, statistical reporting, and data visualization. Hands-on experience or academic exposure to pharmacometric platforms such as Monolix, or NONMEM
- Experience supporting clinical development programs, preferably involving biologics, antibodies, or immunology/inflammation therapeutics
- Knowledge of PK, PD, exposure-response relationships, immunogenicity assessments, and clinical pharmacology principles
- Experience working with external CROs and bioanalytical laboratories
- Strong scientific communication and data presentation skills
- Experience contributing to regulatory documentation is preferred
- Ability to travel up to 10% as needed
The posted range reflects the current reasonable and good faith estimate of the base salary for this full-time position. Actual compensation will be based on a variety of factors including, but not limited to, relevant skills and experience, educational background and certifications, performance and qualifications, market demand for the role, geographic location and other organizational needs. This role also offers a competitive target bonus, equity, and a comprehensive benefits package.
We are committed to fair pay practices, and we regularly review our compensation programs to ensure they are competitive, equitable, and aligned with our values. Please note that the advertised pay range is not a guarantee or promise of a specific wage.
Triveni Bio, along with other biotech companies, has become aware of a surge in email scams targeting prospective job candidates within our industry. Official Triveni Bio applications will always be submitted through Lever, our ATS. Any applications that take you to other platforms could be fraudulent. We do not use text or chat applications to conduct interviews or make job offers. Official Triveni Bio correspondence will always be conducted from email addresses ending in @triveni.bio or @hire.lever.co. Please disregard any other communications that do not originate from these domain names. If you receive any suspicious requests or communications, please verify their authenticity before responding.
Search F-1 STEM OPT Jobs by Industry in Massachusetts
Tips for Finding STEM OPT Jobs in Massachusetts
Verify your role qualifies under STEM OPT
Cross-reference your job title and STEM degree classification against the official STEM Designated Degree Program List before accepting an offer. Many hybrid roles in Massachusetts biotech and data science sit on the boundary, and a mismatch delays your E-Verify enrollment with the employer.
Target E-Verify enrolled employers early
STEM OPT requires your employer to be enrolled in E-Verify before your extension starts. Search the E-Verify employer database to confirm enrollment status before investing time in an application cycle, especially with smaller Cambridge startups and Route 128 spinoffs.
Use Migrate Mate to find verified sponsoring employers
Filter Massachusetts employers by STEM OPT filing history using Migrate Mate, which surfaces DOL Labor Condition Application data by role and location. This cuts out companies that recruit international candidates but lack the E-Verify infrastructure to legally employ you.
File your I-983 training plan before your OPT expires
Your employer must sign the I-983 and your DSO must update SEVIS before your current OPT end date. In Massachusetts life sciences, onboarding timelines at large employers like hospital systems or biotech firms can run six to eight weeks, so start the paperwork the week you receive your signed offer.
See all 1,077+ F-1 STEM OPT jobs in Massachusetts
Sign up for free to unlock all listings, filter by visa type, and get alerts for new F-1 STEM OPT jobs in Massachusetts.
Get Access To All JobsF-1 STEM OPT Jobs in Massachusetts: Frequently Asked Questions
Which industries in Massachusetts sponsor the most F-1 STEM OPT visas?
Biotechnology, life sciences, software engineering, and electrical engineering dominate F-1 STEM OPT sponsorship in Massachusetts. The Greater Boston and Cambridge corridor hosts a dense concentration of biopharma employers, medical device companies, and technology firms that routinely hire STEM OPT graduates. Defense contractors and robotics companies along the Route 128 corridor are also active sponsors.
Which cities in Massachusetts have the most F-1 STEM OPT sponsorship jobs?
Cambridge and Boston account for the largest share of F-1 STEM OPT positions, driven by proximity to major research universities and a high concentration of biotech and software employers. Waltham, Lexington, and Burlington along Route 128 are secondary hubs with established STEM employers. Worcester is growing in life sciences and medical technology sponsorship as well.
What types of roles typically qualify for F-1 STEM OPT sponsorship in Massachusetts?
Roles that qualify must have a STEM degree classification listed on the STEM Designated Degree Program List and require a degree in a STEM field directly related to the position. In Massachusetts, this commonly includes software engineering, data science, bioinformatics, chemical engineering, electrical engineering, and biomedical research roles. You can verify STEM degree classification alignment using O*NET occupation profiles.
How do I find F-1 STEM OPT jobs in Massachusetts?
Migrate Mate lets you filter Massachusetts employers by verified STEM OPT filing history, showing which companies have active DOL LCA records and confirmed E-Verify enrollment. This is faster than applying broadly and discovering mid-process that an employer isn't set up for STEM OPT. You can also cross-check employer E-Verify status directly through the E-Verify employer search tool.
Are there any Massachusetts-specific considerations for F-1 STEM OPT sponsorship?
Massachusetts has no state-level visa sponsorship requirements, but the high density of startups in Cambridge and Boston means many employers are early-stage and may not yet be enrolled in E-Verify, which is a federal requirement for STEM OPT. Confirming E-Verify status before applying saves significant time. Massachusetts also enforces strict salary equity laws, which can affect how employers structure LCA wage certifications.