Administrative Assistant Jobs in South Carolina

Administrative Assistant jobs in South Carolina are open across Columbia, Charleston, and Greenville and other South Carolina metros, with employers like Medical University of South Carolina, Prisma Health, and McLeod Health hiring at every experience level. Find a role that fits below and apply directly.

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Overview

Open roles737+
Top cityColumbia, SC
Cities hiring94
Work type99% On-site
Top industryHealthcare

Showing 5 of 737+ Administrative Assistant jobs

University of South Carolina
Administrative Assistant
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University of South Carolina
Added 4d ago
Administrative Assistant
University of South Carolina
Spartanburg, South Carolina
Administrative & Office Support
Human Resources
Customer Service & Support
$37k - $45k/yr
On-Site
High School
5,001-10,000

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City of Greenville, SC
Senior Administrative Assistant
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City of Greenville, SC
Added 5d ago
Senior Administrative Assistant
City of Greenville, SC
Greenville, South Carolina
Administrative & Office Support
Office Management
$52k - $66k/yr
On-Site
Associate's
501-1,000

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Bamberg County School District
Administrative Assistant to Superintendent & Secretary to the School Board
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Bamberg County School District
Added 1w ago
Administrative Assistant to Superintendent & Secretary to the School Board
Bamberg County School District
Denmark, South Carolina
Administrative & Office Support
Office Management
On-Site
Associate's

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Medical University of South Carolina
Administrative Assistant II
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Medical University of South Carolina
Added 1w ago
Administrative Assistant II
Medical University of South Carolina
Charleston, South Carolina
Administrative & Office Support
Office Management
On-Site
High School
10,000+

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PORT CITY CONCRETE
Fleet Maintenance Administrative Assistant
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PORT CITY CONCRETE
Added 2w ago
Fleet Maintenance Administrative Assistant
PORT CITY CONCRETE
Harleyville, South Carolina
Administrative & Office Support
Procurement & Supply Chain
Logistics & Fleet Management
$24 - $27/hr
On-Site
Associate's

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See All 737+ Administrative Assistant Jobs in South Carolina

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Administrative Assistant Jobs by City in South Carolina

Where South Carolina roles are concentrated, by current openings.

Columbia
108 jobs
Charleston
85 jobs
Greenville
74 jobs
Florence
49 jobs
Greenwood
42 jobs
West Columbia
22 jobs
Myrtle Beach
19 jobs
Sumter
17 jobs
Mount Pleasant
15 jobs

Administrative Assistant Job Market in South Carolina

A snapshot from current South Carolina openings, updated as new roles post.

Who's Hiring

  • Medical University of South Carolina
    Medical University of South Carolina173
  • Prisma Health
    Prisma Health169
  • McLeod Health
    McLeod Health62
  • Self Regional Healthcare
    Self Regional Healthcare58
  • Lexington Health
    Lexington Health43

Top Industries Hiring

  • Healthcare & Medical Services562
  • Education109
  • Consulting & Professional Services21
  • Retail14
  • Construction & Real Estate6

What South Carolina Employers Look For

The qualifications that appear most often in administrative assistant jobs across South Carolina.

  • Proficiency in Microsoft Office Suite, especially Word, Excel, Outlook, and PowerPoint
  • Strong written and verbal communication skills for internal and external correspondence
  • Experience managing calendars, scheduling meetings, and coordinating travel arrangements
  • Ability to handle confidential information with discretion and professionalism
  • Associate or bachelor's degree, or equivalent administrative work experience
  • Familiarity with office management software such as Concur, Salesforce, or Google Workspace

Administrative Assistant Jobs in South Carolina: Frequently Asked Questions

How many administrative assistant jobs are there in South Carolina?

There are 737+ administrative assistant openings in South Carolina on Migrate Mate as of June 2026, with the most roles in Columbia, Charleston, and Greenville. New positions post regularly as employers across South Carolina hire.

How much do administrative assistants make in South Carolina?

Administrative assistants in South Carolina earn a median of about $60,890 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $42,600 for the lowest 10% to over $92,370 for the top 10%. Pay rises with experience, specialty, and employer.

Which South Carolina cities have the most administrative assistant jobs?

Columbia, Charleston, and Greenville have the most administrative assistant openings in South Carolina right now, with additional roles spread across smaller metros statewide.

Which companies hire administrative assistants in South Carolina?

Employers hiring administrative assistants in South Carolina include Medical University of South Carolina, Prisma Health, and McLeod Health, based on current listings on Migrate Mate as of June 2026.

Are there remote administrative assistant jobs in South Carolina?

Yes. About 1% of administrative assistant openings tied to South Carolina are remote or hybrid as of June 2026. The rest are on-site roles based in South Carolina metros.

How do I apply for administrative assistant jobs in South Carolina?

You can apply to administrative assistant jobs in South Carolina directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred South Carolina location, then apply to each one that fits.

See All 737+ Administrative Assistant Jobs in South Carolina

Find roles in South Carolina that match your experience and apply in just a few clicks.

Find Administrative Assistant Jobs