Science & Research E-3 Sponsorship Jobs in California
California is one of the strongest states for science and research E-3 visa sponsorship, with major employers across biotechnology in San Diego and South San Francisco, national laboratories near Berkeley and Livermore, and pharmaceutical giants throughout the Bay Area and Los Angeles. Australian scientists, researchers, and analysts with relevant degrees will find a dense concentration of E-3-eligible roles here.
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Get Access To All JobsAbout Rezo Therapeutics
Rezo is a different kind of biopharma company. Our mission is to dramatically increase the success rate of drug development by building a disease-agnostic, fully-integrated, network biology platform that will redefine our understanding of human disease and ability to treat it.
We are leveraging a unique integrated approach, combining capabilities in genetics, proteomics, structural biology and AI to generate deep biological insights and novel therapeutic approaches.
Located in San Francisco’s vibrant Mission Bay neighborhood, Rezo is in close proximity to UCSF, numerous urban amenities, and outdoor recreational opportunities. We recognize that realizing our mission depends as much on our people as it does on our science and are building a workplace that fosters collaboration, respect, and diversity where contributing to your team’s success is valued as highly as individual achievements. If you’re passionate about team science and breaking down barriers to progress in drug development, please consider joining us!
The Opportunity
Rezo Therapeutics is advancing a new approach to small-molecule drug discovery focused on targeting disease-relevant protein complexes. We are seeking an accomplished Senior Vice President of Chemistry & CMC to lead medicinal chemistry and the transition of innovative programs from advanced lead optimization through development candidate nomination, IND-enabling development, and clinical readiness. This executive will combine scientific judgment with practical execution.
What You'll Do:
- Own chemistry strategy and execution across the small-molecule portfolio, with particular focus on late-stage lead optimization, candidate quality, developability, and clear nomination criteria
- Lead integrated compound optimization using structural and mechanistic insights, pharmacology, DMPK, safety, physicochemical properties, synthetic tractability, and translational objectives; anticipate and resolve program risks
- Drive rigorous development candidate selection, including definition of backup strategies and assessment of route scalability, formulation feasibility, and intellectual property
- Lead the CMC strategy for nominated candidates through IND-enabling studies and first-in-human readiness, spanning drug substance, drug product, analytical development, and phase-appropriate control strategies
- Provide accountable oversight of CROs and CDMOs: partner selection, scopes of work, technical decisions, budgets, quality, risk mitigation, technology transfer, and milestone delivery
- Build, mentor, and develop a high-performing internal chemistry organization while leveraging external capabilities; establish a culture of scientific rigor, transparent decision-making, urgency, and accountability
- Collaborate closely with biology, structural biology, computational sciences, pharmacology, and leadership to integrate emerging data and make disciplined portfolio decisions
- Lead the expansion of our chemistry platform for the identification and optimization of protein complex modulators
- Lead intellectual property strategy with patent counsel; communicate program progress effectively to executive leadership, investors, and the Board
What You'll Bring:
- PhD in chemistry, or a closely related discipline, with approximately 15–20+ years of relevant pharmaceutical or biotechnology industry experience and significant progressive leadership responsibility
- A compelling track record of late-stage small-molecule lead optimization and successful development candidate nomination for oncology indication, with direct accountability for advancing at least assets through IND-enabling studies
- Strong medicinal chemistry expertise, including optimizing oral exposure of beyond-Rule-of-5 molecules
- Substantive hands-on leadership of small-molecule CMC activities
- Clear, persuasive communication and the ability to operate both strategically and hands-on in a resource-conscious, fast-moving biotech environment
Leadership Profile
The successful candidate is a decisive, scientifically rigorous leader who enjoys both defining strategy and getting into the details that determine whether a promising molecule can become a medicine. They will be collaborative, pragmatic, comfortable challenging assumptions, and effective at developing a talented group of people.
Compensation at Rezo
The expected starting salary range for this position based in San Francisco, California for Senior Vice President level is $270,000-$370,000. Actual starting salary will be determined based on multiple job-related factors including candidate’s skills, education, and experience, the level at which they are hired, market demand, business needs, and internal parity. This role is eligible for participation in our Annual Discretionary Bonus Plan (based on individual and company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies. This position is also eligible for the benefits detailed below.
Benefits at Rezo
Medical (HMO or PPO), dental, and vision insurance
Discretionary time off policy
Company holidays (including summer and winter shutdown)
401(k) retirement savings program
Commuter / Mass Transit Benefit Program
Healthcare Flexible Spending Account (FSA)
Dependent care Flexible Spending Account (FSA)
Parental leave
Competitive compensation
Flexible work schedule
EEOC
At Rezo we value a diverse, equitable, inclusive workplace and provide equal employment opportunity to all persons without regard to race, color, sex, gender identity, gender expression, religion, age, national origin, ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. This statement covers all facets of employment and is especially important when it comes to growing our team.
If you are wondering if you’ll belong at Rezo, or are worried that you don’t meet 100% of the qualifications for this role, take a chance on us and yourself — please apply!
SF Fair Chance Ordinance
Pursuant to the San Francisco Fair Chance Ordinance, Rezo considers qualified applicants with arrest and conviction records for employment.
We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.
About Rezo Therapeutics
Rezo is a different kind of biopharma company. Our mission is to dramatically increase the success rate of drug development by building a disease-agnostic, fully-integrated, network biology platform that will redefine our understanding of human disease and ability to treat it.
We are leveraging a unique integrated approach, combining capabilities in genetics, proteomics, structural biology and AI to generate deep biological insights and novel therapeutic approaches.
Located in San Francisco’s vibrant Mission Bay neighborhood, Rezo is in close proximity to UCSF, numerous urban amenities, and outdoor recreational opportunities. We recognize that realizing our mission depends as much on our people as it does on our science and are building a workplace that fosters collaboration, respect, and diversity where contributing to your team’s success is valued as highly as individual achievements. If you’re passionate about team science and breaking down barriers to progress in drug development, please consider joining us!
The Opportunity
Rezo Therapeutics is advancing a new approach to small-molecule drug discovery focused on targeting disease-relevant protein complexes. We are seeking an accomplished Senior Vice President of Chemistry & CMC to lead medicinal chemistry and the transition of innovative programs from advanced lead optimization through development candidate nomination, IND-enabling development, and clinical readiness. This executive will combine scientific judgment with practical execution.
What You'll Do:
- Own chemistry strategy and execution across the small-molecule portfolio, with particular focus on late-stage lead optimization, candidate quality, developability, and clear nomination criteria
- Lead integrated compound optimization using structural and mechanistic insights, pharmacology, DMPK, safety, physicochemical properties, synthetic tractability, and translational objectives; anticipate and resolve program risks
- Drive rigorous development candidate selection, including definition of backup strategies and assessment of route scalability, formulation feasibility, and intellectual property
- Lead the CMC strategy for nominated candidates through IND-enabling studies and first-in-human readiness, spanning drug substance, drug product, analytical development, and phase-appropriate control strategies
- Provide accountable oversight of CROs and CDMOs: partner selection, scopes of work, technical decisions, budgets, quality, risk mitigation, technology transfer, and milestone delivery
- Build, mentor, and develop a high-performing internal chemistry organization while leveraging external capabilities; establish a culture of scientific rigor, transparent decision-making, urgency, and accountability
- Collaborate closely with biology, structural biology, computational sciences, pharmacology, and leadership to integrate emerging data and make disciplined portfolio decisions
- Lead the expansion of our chemistry platform for the identification and optimization of protein complex modulators
- Lead intellectual property strategy with patent counsel; communicate program progress effectively to executive leadership, investors, and the Board
What You'll Bring:
- PhD in chemistry, or a closely related discipline, with approximately 15–20+ years of relevant pharmaceutical or biotechnology industry experience and significant progressive leadership responsibility
- A compelling track record of late-stage small-molecule lead optimization and successful development candidate nomination for oncology indication, with direct accountability for advancing at least assets through IND-enabling studies
- Strong medicinal chemistry expertise, including optimizing oral exposure of beyond-Rule-of-5 molecules
- Substantive hands-on leadership of small-molecule CMC activities
- Clear, persuasive communication and the ability to operate both strategically and hands-on in a resource-conscious, fast-moving biotech environment
Leadership Profile
The successful candidate is a decisive, scientifically rigorous leader who enjoys both defining strategy and getting into the details that determine whether a promising molecule can become a medicine. They will be collaborative, pragmatic, comfortable challenging assumptions, and effective at developing a talented group of people.
Compensation at Rezo
The expected starting salary range for this position based in San Francisco, California for Senior Vice President level is $270,000-$370,000. Actual starting salary will be determined based on multiple job-related factors including candidate’s skills, education, and experience, the level at which they are hired, market demand, business needs, and internal parity. This role is eligible for participation in our Annual Discretionary Bonus Plan (based on individual and company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies. This position is also eligible for the benefits detailed below.
Benefits at Rezo
Medical (HMO or PPO), dental, and vision insurance
Discretionary time off policy
Company holidays (including summer and winter shutdown)
401(k) retirement savings program
Commuter / Mass Transit Benefit Program
Healthcare Flexible Spending Account (FSA)
Dependent care Flexible Spending Account (FSA)
Parental leave
Competitive compensation
Flexible work schedule
EEOC
At Rezo we value a diverse, equitable, inclusive workplace and provide equal employment opportunity to all persons without regard to race, color, sex, gender identity, gender expression, religion, age, national origin, ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. This statement covers all facets of employment and is especially important when it comes to growing our team.
If you are wondering if you’ll belong at Rezo, or are worried that you don’t meet 100% of the qualifications for this role, take a chance on us and yourself — please apply!
SF Fair Chance Ordinance
Pursuant to the San Francisco Fair Chance Ordinance, Rezo considers qualified applicants with arrest and conviction records for employment.
We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.
E-3 Science & Research Job Roles in California
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Search Science & Research Jobs in CaliforniaScience & Research E-3 Sponsorship Jobs in California: Frequently Asked Questions
Which science and research companies sponsor E-3 visas in California?
California's science and research sector includes major E-3 visa sponsors such as Genentech, Gilead Sciences, and Amgen in the Bay Area, along with Illumina and Salk Institute in San Diego. National laboratories including Lawrence Berkeley and Lawrence Livermore also employ international researchers. University of California campuses across the state regularly sponsor E-3 visas for postdoctoral researchers and staff scientists.
Which cities in California have the most science and research E-3 sponsorship jobs?
San Diego and the San Francisco Bay Area account for the largest share of science and research E-3 opportunities in California. San Diego's Torrey Pines corridor is dense with biotech and pharmaceutical employers. South San Francisco hosts a well-known cluster of life sciences companies. Los Angeles has growing research activity through institutions like UCLA, Caltech, and City of Hope.
What types of science and research roles typically qualify for E-3 sponsorship?
Roles that qualify for E-3 sponsorship must meet the specialty occupation standard, requiring at least a bachelor's degree in a specific field directly related to the position. In science and research, this includes positions such as research scientist, bioinformatician, clinical research associate, chemist, biostatistician, and lab scientist. Generic research assistant roles that don't require a specific degree field are less likely to qualify.
How do I find science and research E-3 sponsorship jobs in California?
Migrate Mate is built specifically to surface E-3 visa sponsorship jobs, including science and research roles in California. You can filter by state and industry to see positions from employers with a track record of E-3 sponsorship. Because E-3 eligibility depends on both the role and the employer's willingness to sponsor, using a platform like Migrate Mate that filters by visa type saves significant time compared to searching general job boards.
Are there any California-specific or industry-specific considerations for science and research E-3 sponsorship?
California's life sciences industry is highly competitive, and many employers are familiar with E-3 sponsorship given the volume of international talent they hire. However, state-level licensing requirements can apply for certain roles, particularly in clinical research and environmental science. Australian three-year bachelor's degrees are generally accepted as equivalent to U.S. four-year degrees for E-3 purposes, though individual employers may request credential evaluations.
What is the prevailing wage for E-3 science & research jobs in California?
U.S. employers sponsoring a visa must pay at least the prevailing wage, which is what workers in the same role, area, and experience level typically earn. The Department of Labor sets this rate to make sure companies aren't hiring foreign workers simply because they'd accept lower pay than a U.S. worker. It varies by job title, location, and experience. You can look up current prevailing wage rates for any occupation and location using the OFLC Wage Search page.