Regional Manager Jobs in South Carolina
Regional Manager jobs in South Carolina are most active in Columbia, Charleston, and Greenville, where employers across retail, logistics, healthcare, and manufacturing maintain multi-unit or multi-site operations that require experienced regional leadership. Companies such as Michelin, Prisma Health, and Walmart have established large footprints in the state and consistently hire regional managers to oversee distributed teams and drive operational performance. Demand is strongest in operations management, retail and consumer goods, and healthcare services administration. See the openings below and apply to the ones that match your experience.
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At Aspen Dental, we put You first, offering the security and job stability that comes with working with a world-class dental service organization (DSO). Our best-in-class training program, competitive compensation, and opportunity for advancement will help you thrive in your career. When you join our team as a Regional Manager, you will have the opportunity to give back to communities and positively affect patients’ lives.
Salary: $85,000 + / year + incentive opportunity
At Aspen Dental, we put You First. We offer:
Career development and growth opportunities with our best-in-class training program to support you at every stage of your career
A fun and supportive culture that encourages collaboration and innovation
Free Continuing Education (CE) through TAG U
A generous benefits package that includes paid time off, health, dental, vision, and 401(k) savings plan with match**
How You’ll Make a Difference
As a Regional Manager, you will oversee practice operations for a group of 6-10 Aspen Dental branded practices. You will play a critical role spearheading growth and process improvement initiatives, own full profit and loss responsibility, and develop close working partnerships with the entire practice staff.
Travel to nearby offices to support practice operations* (3-4 days per week).During training, you will be onsite at an Aspen Dental location 5 days per week
Provide training and development support to ensure all practice staff demonstrate knowledge of the business model, operating procedures, and protocols
In partnership with the talent acquisition team and the office manager, evaluate and communicate staffing needs to enable effective hiring and onboarding experiences for new team members
Support daily office operations within the region as necessary
Qualifications:
Availability to relocate after 6 months of local training is required (relocation assistance provided)
Management experience over-seeing multiple locations in the retail or health care industry
Prior profit and loss responsibility and the ability to interpret and act upon financial statements
Knowledge of Microsoft Office business applications
Strong communication and interpersonal skills, with the ability to build rapport with patients and employees of all ages and backgrounds
Commitment to ongoing learning and professional development for yourself and your team
Bachelor’s degree preferred
- As this position requires daily travel to assigned offices, you must maintain a valid non-restricted driver’s license and appropriate insurance or the ability to be insured under the employer’s fleet insurance program (for those assigned a Company fleet vehicle). The Company reserves the right to request and review your Motor Vehicle Record at any time, according to state requirements.
**May vary by independently owned and operated Aspen Dental locations.
ADMI Corp., d/b/a TAG-The Aspen Group, its affiliates, related companies and independently owned supported clinical practices are proud to be Equal Opportunity Employers and welcome everyone to apply. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
See All 59 Regional Manager Jobs in South Carolina
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Find Regional Manager JobsRegional Manager Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
Regional Manager Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring



What South Carolina Employers Look For
The qualifications that appear most often in regional manager jobs across South Carolina.
- Bachelor's degree in business administration, management, or a related field required
- Five or more years of multi-unit or multi-site management experience strongly preferred
- Demonstrated ability to lead, coach, and develop teams across multiple locations
- Proven ability to manage P&L, budgets, and financial performance at a regional level
- Proficiency with CRM platforms, ERP systems, or operations management software
- Willingness to travel regularly within an assigned South Carolina territory
Regional Manager Jobs in South Carolina: Frequently Asked Questions
How do you become a regional manager in South Carolina?
Most regional managers in South Carolina move into the role after building several years of experience as a store manager, district supervisor, or department director within their industry. South Carolina does not require a state-issued license for general regional management, but roles in regulated industries like healthcare or financial services may require relevant professional credentials. A bachelor's degree in business or a related field is the standard baseline most South Carolina employers expect.
How much do regional managers make in South Carolina?
Regional managers in South Carolina earn a median of about $106,080 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $56,520 for the lowest 10% to over $219,350 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire regional managers in South Carolina?
Companies currently hiring regional managers in South Carolina include Target, Walmart, and Summerfield Management, per current listings on Migrate Mate as of November 2026. South Carolina's mix of manufacturing anchors, large healthcare systems, and national retail chains creates steady regional manager demand across multiple industries throughout the state.
Which South Carolina cities have the most regional manager jobs?
The cities with the most regional manager openings in South Carolina are Charleston, Greenville, and Lugoff. Columbia draws hiring from state government contractors, healthcare networks, and financial services firms, Charleston benefits from its port-driven logistics and hospitality sectors, and Greenville reflects the manufacturing and automotive supplier base concentrated in the Upstate region.
Are there remote regional manager jobs in South Carolina?
Yes, but they're rare. Regional management typically requires in-person presence across multiple locations, which limits full-remote arrangements. About 91% of regional manager openings tied to South Carolina are remote or hybrid as of November 2026, and those positions tend to concentrate in functions like sales management or account-based operations where physical oversight of a facility is not required.
How can I get hired as a regional manager in South Carolina with little or no experience?
The most realistic entry path is building a record in a single-unit management role first. Large South Carolina employers such as Prisma Health, Michelin, and national retailers operating in Columbia and Greenville run management development programs that advance store managers and department leads into multi-site roles. Moving from an assistant manager, operations supervisor, or area coordinator title into a district or regional role is the common progression, and a business degree or PMP credential strengthens a candidate's case considerably.
Where can I find and apply to regional manager jobs in South Carolina?
You can find and apply to regional manager jobs in South Carolina on Migrate Mate, which lists current openings across the state. Search the listings, find roles that match your background and location preferences, and apply directly to the ones that fit.
See All 59 Regional Manager Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find Regional Manager Jobs