Regional Manager Jobs in South Carolina

Regional Manager jobs in South Carolina are most active in Columbia, Charleston, and Greenville, where employers across retail, logistics, healthcare, and manufacturing maintain multi-unit or multi-site operations that require experienced regional leadership. Companies such as Michelin, Prisma Health, and Walmart have established large footprints in the state and consistently hire regional managers to oversee distributed teams and drive operational performance. Demand is strongest in operations management, retail and consumer goods, and healthcare services administration. See the openings below and apply to the ones that match your experience.

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Overview

Open roles59
Top employerTarget
Top cityCharleston, SC
Cities hiring27
Work type55% Remote
Top credentialBachelor's degree

Showing 5 of 59+ Regional Manager jobs

Relocatable Regional Manager
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New 14h ago
Relocatable Regional Manager
Aspen Dental
Myrtle Beach, South Carolina
Clinical Support
Healthcare Administration
Human Resources
Nursing
Bachelor's degree
10,000+

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Regional Transit Program Manager I (61032868)
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Added 1d ago
Regional Transit Program Manager I (61032868)
State of South Carolina
Richland County, SC
Business Development
Program Management
Project Management
$68k - $122k/yr
Bachelor's degree
10,000+

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Manager, SE Regional Plant Engineering
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Added 1d ago
Manager, SE Regional Plant Engineering
Cable One
Bluffton, South Carolina
Creative & Design
Product Management
Project & Program Management
Project Management
Bachelor of Science
1,001-5,000

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Regional Manager, Business Development
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Added 2d ago
Regional Manager, Business Development
Caliber
Taylors, South Carolina
Customer Service
Customer Support
10,000+

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Regional Manager, Interventional Solutions, Charleston/Myrtle Beach, SC
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Added 2d ago
Regional Manager, Interventional Solutions, Charleston/Myrtle Beach, SC
Boston Scientific
Florence, South Carolina
Account Management
Business Development
Sales
Master's degree in business administration
10,000+

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See All 59 Regional Manager Jobs in South Carolina

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Regional Manager Jobs by City in South Carolina

Where South Carolina roles are concentrated, by current openings.

Charleston
8 jobs
Greenville
8 jobs
Lugoff
4 jobs
Columbia
4 jobs
Greer
3 jobs
Spartanburg
3 jobs
Laurens
2 jobs
Trenton
2 jobs
Fort Mill
2 jobs

Regional Manager Job Market in South Carolina

A snapshot from current South Carolina openings, updated as new roles post.

Who's Hiring

Target4 open roles
Walmart3 open roles
Summerfield Management3 open roles

What South Carolina Employers Look For

The qualifications that appear most often in regional manager jobs across South Carolina.

  • Bachelor's degree in business administration, management, or a related field required
  • Five or more years of multi-unit or multi-site management experience strongly preferred
  • Demonstrated ability to lead, coach, and develop teams across multiple locations
  • Proven ability to manage P&L, budgets, and financial performance at a regional level
  • Proficiency with CRM platforms, ERP systems, or operations management software
  • Willingness to travel regularly within an assigned South Carolina territory

Regional Manager Jobs in South Carolina: Frequently Asked Questions

How do you become a regional manager in South Carolina?

Most regional managers in South Carolina move into the role after building several years of experience as a store manager, district supervisor, or department director within their industry. South Carolina does not require a state-issued license for general regional management, but roles in regulated industries like healthcare or financial services may require relevant professional credentials. A bachelor's degree in business or a related field is the standard baseline most South Carolina employers expect.

How much do regional managers make in South Carolina?

Regional managers in South Carolina earn a median of about $106,080 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $56,520 for the lowest 10% to over $219,350 for the top 10%. Pay rises with experience, specialty, and employer.

Which companies hire regional managers in South Carolina?

Companies currently hiring regional managers in South Carolina include Target, Walmart, and Summerfield Management, per current listings on Migrate Mate as of November 2026. South Carolina's mix of manufacturing anchors, large healthcare systems, and national retail chains creates steady regional manager demand across multiple industries throughout the state.

Which South Carolina cities have the most regional manager jobs?

The cities with the most regional manager openings in South Carolina are Charleston, Greenville, and Lugoff. Columbia draws hiring from state government contractors, healthcare networks, and financial services firms, Charleston benefits from its port-driven logistics and hospitality sectors, and Greenville reflects the manufacturing and automotive supplier base concentrated in the Upstate region.

Are there remote regional manager jobs in South Carolina?

Yes, but they're rare. Regional management typically requires in-person presence across multiple locations, which limits full-remote arrangements. About 91% of regional manager openings tied to South Carolina are remote or hybrid as of November 2026, and those positions tend to concentrate in functions like sales management or account-based operations where physical oversight of a facility is not required.

How can I get hired as a regional manager in South Carolina with little or no experience?

The most realistic entry path is building a record in a single-unit management role first. Large South Carolina employers such as Prisma Health, Michelin, and national retailers operating in Columbia and Greenville run management development programs that advance store managers and department leads into multi-site roles. Moving from an assistant manager, operations supervisor, or area coordinator title into a district or regional role is the common progression, and a business degree or PMP credential strengthens a candidate's case considerably.

Where can I find and apply to regional manager jobs in South Carolina?

You can find and apply to regional manager jobs in South Carolina on Migrate Mate, which lists current openings across the state. Search the listings, find roles that match your background and location preferences, and apply directly to the ones that fit.

See All 59 Regional Manager Jobs in South Carolina

Find roles in South Carolina that match your experience and apply in just a few clicks.

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